Q9I816 (OR19A_DROME) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 84.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Putative odorant receptor 19a | ||||
| Gene names |
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| Organism | Drosophila melanogaster (Fruit fly) | ||||
| Taxonomic identifier | 7227 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 387 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide By similarity. |
| Subunit structure | Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway By similarity. |
| Subcellular location | Cell membrane; Multi-pass membrane protein By similarity. |
| Miscellaneous | The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways. |
| Sequence similarities | Belongs to the heteromeric odorant receptor channel (TC 1.A.69) family. [View classification] |
Ontologies
| Keywords | |
|---|---|
| Biological process | Olfaction Sensory transduction |
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane Transmembrane helix |
| Molecular function | G-protein coupled receptor Receptor Transducer |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW odorant bindingInferred from electronic annotation. Source: InterPro olfactory receptor activityInferred from direct assay. Source: FlyBase |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 387 | 387 | Putative odorant receptor 19a | PRO_0000174230 | |||||
Regions | |||||||||
| Topological domain | 1 – 40 | 40 | Cytoplasmic Potential | ||||||
| Transmembrane | 41 – 61 | 21 | Helical; Name=1; Potential | ||||||
| Topological domain | 62 – 71 | 10 | Extracellular Potential | ||||||
| Transmembrane | 72 – 92 | 21 | Helical; Name=2; Potential | ||||||
| Topological domain | 93 – 127 | 35 | Cytoplasmic Potential | ||||||
| Transmembrane | 128 – 148 | 21 | Helical; Name=3; Potential | ||||||
| Topological domain | 149 – 171 | 23 | Extracellular Potential | ||||||
| Transmembrane | 172 – 192 | 21 | Helical; Name=4; Potential | ||||||
| Topological domain | 193 – 254 | 62 | Cytoplasmic Potential | ||||||
| Transmembrane | 255 – 275 | 21 | Helical; Name=5; Potential | ||||||
| Topological domain | 276 – 285 | 10 | Extracellular Potential | ||||||
| Transmembrane | 286 – 306 | 21 | Helical; Name=6; Potential | ||||||
| Topological domain | 307 – 336 | 30 | Cytoplasmic Potential | ||||||
| Transmembrane | 337 – 357 | 21 | Helical; Name=7; Potential | ||||||
| Topological domain | 358 – 387 | 30 | Extracellular Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. Venter J.C.Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley. |
| [2] | "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. Lewis S.E.Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE014298 Genomic DNA. Translation: AAG22450.2. |
| RefSeq | NP_525013.2. NM_080274.3. |
| UniGene | Dm.27529. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9I816. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblMetazoa | FBtr0070029; FBpp0070028; FBgn0041626. |
| GeneID | 59214. |
| KEGG | dme:Dmel_CG18859. |
Organism-specific databases | |
| CTD | 59214. |
| FlyBase | FBgn0041626. Or19a. |
Phylogenomic databases | |
| GeneTree | EMGT00050000009319. |
| InParanoid | Q9I816. |
| OrthoDB | EOG4CC2H7. |
| PhylomeDB | Q9I816. |
Gene expression databases | |
| GermOnline | CG18859. Drosophila melanogaster. |
Family and domain databases | |
| InterPro | IPR004117. 7tm6_olfct_rcpt. [Graphical view] |
| KO | K08471. |
| PANTHER | PTHR21137. 7tm6_olfct_rcpt. 1 hit. |
| Pfam | PF02949. 7tm_6. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 841649. |
Entry information
| Entry name | OR19A_DROME | ||||||||
| Accession | Primary (citable) accession number: Q9I816 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| SIMILARITY comments Index of protein domains and families |

Clusters with