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Protein

Tyrosine-protein kinase PR2

Gene

PR2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei164ATPPROSITE-ProRule annotation1
Active sitei260Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi139 – 147ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase PR2 (EC:2.7.10.2)
Gene namesi
Name:PR2
ORF Names:CG3969
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0013955. PR2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000881321 – 1337Tyrosine-protein kinase PR2Add BLAST1337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei71Phosphoserine1 Publication1
Modified residuei291Phosphotyrosine1 Publication1
Modified residuei292Phosphotyrosine1 Publication1
Modified residuei764Phosphoserine1 Publication1
Modified residuei778Phosphoserine1 Publication1
Modified residuei831Phosphoserine1 Publication1
Modified residuei918Phosphoserine1 Publication1
Modified residuei924Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9I7F7.
PRIDEiQ9I7F7.

PTM databases

iPTMnetiQ9I7F7.

Expressioni

Gene expression databases

BgeeiFBgn0263998.
ExpressionAtlasiQ9I7F7. baseline.
GenevisibleiQ9I7F7. DM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9I7F7. 3 interactors.
STRINGi7227.FBpp0303364.

Structurei

3D structure databases

ProteinModelPortaliQ9I7F7.
SMRiQ9I7F7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 399Protein kinasePROSITE-ProRule annotationAdd BLAST267
Domaini488 – 502CRIBPROSITE-ProRule annotationAdd BLAST15

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
Contains 1 CRIB domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0199. Eukaryota.
ENOG410XPRC. LUCA.
GeneTreeiENSGT00760000118799.
InParanoidiQ9I7F7.
PhylomeDBiQ9I7F7.

Family and domain databases

Gene3Di3.90.810.10. 1 hit.
InterProiIPR000095. CRIB_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00786. PBD. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00285. PBD. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50108. CRIB. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9I7F7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYPQIDLYE FLTESELQQY YNAVKNELKI TNAAQFKYAA DEDLRFIGLS
60 70 80 90 100
RPEIRRLRKF YEKHFPHSYL SKIKRLLQAP GTMVKREEAP GGGSQVALDG
110 120 130 140 150
SSASACSSLA AKNGASSPSK VPNNKHIIPA DSISVNKQLG TGEFGIVQQG
160 170 180 190 200
VWSNGNERIQ VAIKCLCRER MQSNPMEFLK EAAIMHSIEH ENIVRLYGVV
210 220 230 240 250
LATDSLMLVT ELAHLRSLLE CLKDSGLRVS FLTIPTLCEF ALQICNGMRY
260 270 280 290 300
LEQKRLIHRD LAARNILVFS KDKVKISDFG LSRALGVGKD YYKTNFNVNL
310 320 330 340 350
KLPIAWCAPE CINYLRFTNA SDVWAFGVCL WEMFSYGFQP WAALTGLQIL
360 370 380 390 400
EAIDAPNYQR LEQPDCCPSE YYTLMMKCWQ DDAAKRPRFG EIYDQLPDMK
410 420 430 440 450
PEQLKAVVNC TEPKKDHLLY RQGDIISVLD RNTGTPFWKG VLSTGKTGYF
460 470 480 490 500
NPSNTVAFLE GLPSSTRDSF SRVSDHRISK RKLRTEMISK PQNDFKHTGH
510 520 530 540 550
VGIDGATFGD IAFLGSSQNY NHVPKQIVTP YKPSEDIEQT PLLLPPTPTS
560 570 580 590 600
PDSLQTASGY FPEGANSGGA MGTSMNPTFI PSAEHTPKLI ATNGQSSFDF
610 620 630 640 650
ASGSTNPFFP NRGDDELEFG LHNYGADGKS VHSETGWRPT SRSIVDDPHE
660 670 680 690 700
YHEISDDEIA ADKLDFGPSL LDEINSMFGS ISAATGSHPK SPGFDHVNNK
710 720 730 740 750
NEITEMSAKL GQKSGDTNGN KHGHGLLPTL SKKKSSGTVK PISVKDEKIL
760 770 780 790 800
NHAIEIANEI SARSMIDLVS DQTPVIHSPK RKFSFRFPHL SNNGSGDKSG
810 820 830 840 850
GLGTSGSAHT PTHGNASPFP KKKNFTEELQ SIPDIQSLIG KEGLEAYNSL
860 870 880 890 900
IERKALLDIG PSPAATLLRH LDTDEFDLQS LHQSQRPMTL PTRGATQRVR
910 920 930 940 950
KAELAAGLSR HNDENSNSLE ACESPSYMTH GSYKFPEAQP TEQLPEPESP
960 970 980 990 1000
NPIPLPPREG KKQVKTSTKR HVRKYPLIIP ANGLQRTLSK LADFGDEAAK
1010 1020 1030 1040 1050
SPEISTSSQP QPGRAIEVVA AVRPSGMRRP SRPSEREYEN MPTVGKESAH
1060 1070 1080 1090 1100
TYQNLDKLTP ADAAGLTDTA SLQFESIMEA DTSKEGILQS PDVTDGFYNF
1110 1120 1130 1140 1150
SIQKEHYNKG KDAEFEATQI SGLYVNDDEL RNLDIESSRR TATPCSSCSA
1160 1170 1180 1190 1200
LESEHSQPDA LPSTESVSEV SRFSSVDNEL AGNALFKKVR ASVNMAMNRK
1210 1220 1230 1240 1250
SVAETSLTSN QPGGASAKPQ TEAEYFAATA ARLADSNSVS CEDLLEFSDK
1260 1270 1280 1290 1300
KPKGCERGVD SDEVRIMVKV LGKDSTPNRC LGALEFINWD VHKSIKLIKL
1310 1320 1330
QNLVSEANLS LEASFEALQQ HEWDLHTTAH KLNGLKL
Length:1,337
Mass (Da):147,477
Last modified:January 27, 2003 - v3
Checksum:i12650E9DF5A82724
GO

Sequence cautioni

The sequence AAF58423 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA04489 differs from that shown. Reason: Frameshift at positions 752, 806, 816 and 827.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti450F → FSTPFWKGVLSTGKTGYF in BAA04489 (PubMed:8112607).Curated1
Sequence conflicti484R → A in BAA04489 (PubMed:8112607).Curated1
Sequence conflicti906A → P in BAA04489 (PubMed:8112607).Curated1
Sequence conflicti913D → V in BAA04489 (PubMed:8112607).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58423.5. Sequence problems.
AE013599 Genomic DNA. Translation: AAG22275.3.
AY051755 mRNA. Translation: AAK93179.1.
D17551 mRNA. Translation: BAA04489.1. Frameshift.
AJ002909 Genomic DNA. Translation: CAA05744.1.
RefSeqiNP_477086.2. NM_057738.4.
NP_477087.3. NM_057739.4.
UniGeneiDm.4488.

Genome annotation databases

EnsemblMetazoaiFBtr0330329; FBpp0303361; FBgn0263998.
GeneIDi36442.
KEGGidme:Dmel_CG43741.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58423.5. Sequence problems.
AE013599 Genomic DNA. Translation: AAG22275.3.
AY051755 mRNA. Translation: AAK93179.1.
D17551 mRNA. Translation: BAA04489.1. Frameshift.
AJ002909 Genomic DNA. Translation: CAA05744.1.
RefSeqiNP_477086.2. NM_057738.4.
NP_477087.3. NM_057739.4.
UniGeneiDm.4488.

3D structure databases

ProteinModelPortaliQ9I7F7.
SMRiQ9I7F7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9I7F7. 3 interactors.
STRINGi7227.FBpp0303364.

PTM databases

iPTMnetiQ9I7F7.

Proteomic databases

PaxDbiQ9I7F7.
PRIDEiQ9I7F7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0330329; FBpp0303361; FBgn0263998.
GeneIDi36442.
KEGGidme:Dmel_CG43741.

Organism-specific databases

CTDi36442.
FlyBaseiFBgn0013955. PR2.

Phylogenomic databases

eggNOGiKOG0199. Eukaryota.
ENOG410XPRC. LUCA.
GeneTreeiENSGT00760000118799.
InParanoidiQ9I7F7.
PhylomeDBiQ9I7F7.

Miscellaneous databases

GenomeRNAii36442.
PROiQ9I7F7.

Gene expression databases

BgeeiFBgn0263998.
ExpressionAtlasiQ9I7F7. baseline.
GenevisibleiQ9I7F7. DM.

Family and domain databases

Gene3Di3.90.810.10. 1 hit.
InterProiIPR000095. CRIB_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00786. PBD. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00285. PBD. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50108. CRIB. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPR2_DROME
AccessioniPrimary (citable) accession number: Q9I7F7
Secondary accession number(s): Q24316, Q960Z6, Q9V6K0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: January 27, 2003
Last modified: November 30, 2016
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.