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Q9I7F7

- PR2_DROME

UniProt

Q9I7F7 - PR2_DROME

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Protein

Tyrosine-protein kinase PR2

Gene

PR2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei164 – 1641ATPPROSITE-ProRule annotation
Active sitei260 – 2601Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi139 – 1479ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
  3. protein tyrosine kinase activity Source: UniProtKB

GO - Biological processi

  1. autophagic cell death Source: FlyBase
  2. peptidyl-tyrosine phosphorylation Source: GOC
  3. protein phosphorylation Source: UniProtKB
  4. salivary gland cell autophagic cell death Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase PR2 (EC:2.7.10.2)
Gene namesi
Name:PR2
ORF Names:CG3969
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0013955. PR2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13371337Tyrosine-protein kinase PR2PRO_0000088132Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei71 – 711Phosphoserine1 Publication
Modified residuei291 – 2911Phosphotyrosine1 Publication
Modified residuei292 – 2921Phosphotyrosine1 Publication
Modified residuei764 – 7641Phosphoserine1 Publication
Modified residuei778 – 7781Phosphoserine1 Publication
Modified residuei831 – 8311Phosphoserine1 Publication
Modified residuei918 – 9181Phosphoserine1 Publication
Modified residuei924 – 9241Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9I7F7.

Expressioni

Gene expression databases

BgeeiQ9I7F7.
ExpressionAtlasiQ9I7F7. differential.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0086889.

Structurei

3D structure databases

ProteinModelPortaliQ9I7F7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini133 – 399267Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini488 – 50215CRIBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
Contains 1 CRIB domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118799.
InParanoidiQ9I7F7.
PhylomeDBiQ9I7F7.

Family and domain databases

Gene3Di3.90.810.10. 1 hit.
InterProiIPR000095. CRIB_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00786. PBD. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00285. PBD. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50108. CRIB. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: Q9I7F7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEYPQIDLYE FLTESELQQY YNAVKNELKI TNAAQFKYAA DEDLRFIGLS
60 70 80 90 100
RPEIRRLRKF YEKHFPHSYL SKIKRLLQAP GTMVKREEAP GGGSQVALDG
110 120 130 140 150
SSASACSSLA AKNGASSPSK VPNNKHIIPA DSISVNKQLG TGEFGIVQQG
160 170 180 190 200
VWSNGNERIQ VAIKCLCRER MQSNPMEFLK EAAIMHSIEH ENIVRLYGVV
210 220 230 240 250
LATDSLMLVT ELAHLRSLLE CLKDSGLRVS FLTIPTLCEF ALQICNGMRY
260 270 280 290 300
LEQKRLIHRD LAARNILVFS KDKVKISDFG LSRALGVGKD YYKTNFNVNL
310 320 330 340 350
KLPIAWCAPE CINYLRFTNA SDVWAFGVCL WEMFSYGFQP WAALTGLQIL
360 370 380 390 400
EAIDAPNYQR LEQPDCCPSE YYTLMMKCWQ DDAAKRPRFG EIYDQLPDMK
410 420 430 440 450
PEQLKAVVNC TEPKKDHLLY RQGDIISVLD RNTGTPFWKG VLSTGKTGYF
460 470 480 490 500
NPSNTVAFLE GLPSSTRDSF SRVSDHRISK RKLRTEMISK PQNDFKHTGH
510 520 530 540 550
VGIDGATFGD IAFLGSSQNY NHVPKQIVTP YKPSEDIEQT PLLLPPTPTS
560 570 580 590 600
PDSLQTASGY FPEGANSGGA MGTSMNPTFI PSAEHTPKLI ATNGQSSFDF
610 620 630 640 650
ASGSTNPFFP NRGDDELEFG LHNYGADGKS VHSETGWRPT SRSIVDDPHE
660 670 680 690 700
YHEISDDEIA ADKLDFGPSL LDEINSMFGS ISAATGSHPK SPGFDHVNNK
710 720 730 740 750
NEITEMSAKL GQKSGDTNGN KHGHGLLPTL SKKKSSGTVK PISVKDEKIL
760 770 780 790 800
NHAIEIANEI SARSMIDLVS DQTPVIHSPK RKFSFRFPHL SNNGSGDKSG
810 820 830 840 850
GLGTSGSAHT PTHGNASPFP KKKNFTEELQ SIPDIQSLIG KEGLEAYNSL
860 870 880 890 900
IERKALLDIG PSPAATLLRH LDTDEFDLQS LHQSQRPMTL PTRGATQRVR
910 920 930 940 950
KAELAAGLSR HNDENSNSLE ACESPSYMTH GSYKFPEAQP TEQLPEPESP
960 970 980 990 1000
NPIPLPPREG KKQVKTSTKR HVRKYPLIIP ANGLQRTLSK LADFGDEAAK
1010 1020 1030 1040 1050
SPEISTSSQP QPGRAIEVVA AVRPSGMRRP SRPSEREYEN MPTVGKESAH
1060 1070 1080 1090 1100
TYQNLDKLTP ADAAGLTDTA SLQFESIMEA DTSKEGILQS PDVTDGFYNF
1110 1120 1130 1140 1150
SIQKEHYNKG KDAEFEATQI SGLYVNDDEL RNLDIESSRR TATPCSSCSA
1160 1170 1180 1190 1200
LESEHSQPDA LPSTESVSEV SRFSSVDNEL AGNALFKKVR ASVNMAMNRK
1210 1220 1230 1240 1250
SVAETSLTSN QPGGASAKPQ TEAEYFAATA ARLADSNSVS CEDLLEFSDK
1260 1270 1280 1290 1300
KPKGCERGVD SDEVRIMVKV LGKDSTPNRC LGALEFINWD VHKSIKLIKL
1310 1320 1330
QNLVSEANLS LEASFEALQQ HEWDLHTTAH KLNGLKL
Length:1,337
Mass (Da):147,477
Last modified:January 27, 2003 - v3
Checksum:i12650E9DF5A82724
GO
Isoform Short (identifier: Q9I7F7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Show »
Length:1,255
Mass (Da):137,621
Checksum:iAB0C0C1FF2E2816B
GO

Sequence cautioni

The sequence BAA04489.1 differs from that shown. Reason: Frameshift at positions 752, 806, 816 and 827. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti450 – 4501F → FSTPFWKGVLSTGKTGYF(PubMed:8112607)Curated
Sequence conflicti484 – 4841R → A in BAA04489. (PubMed:8112607)Curated
Sequence conflicti906 – 9061A → P(PubMed:8112607)Curated
Sequence conflicti913 – 9131D → V(PubMed:8112607)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8282Missing in isoform Short. CuratedVSP_005006Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58423.4.
AE013599 Genomic DNA. Translation: AAG22275.3.
AY051755 mRNA. Translation: AAK93179.1.
D17551 mRNA. Translation: BAA04489.1. Frameshift.
AJ002909 Genomic DNA. Translation: CAA05744.1.
RefSeqiNP_477086.2. NM_057738.4. [Q9I7F7-1]
NP_477087.3. NM_057739.4.
UniGeneiDm.4488.

Genome annotation databases

EnsemblMetazoaiFBtr0330329; FBpp0303361; FBgn0263998. [Q9I7F7-1]
GeneIDi36442.
KEGGidme:Dmel_CG43741.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58423.4 .
AE013599 Genomic DNA. Translation: AAG22275.3 .
AY051755 mRNA. Translation: AAK93179.1 .
D17551 mRNA. Translation: BAA04489.1 . Frameshift.
AJ002909 Genomic DNA. Translation: CAA05744.1 .
RefSeqi NP_477086.2. NM_057738.4. [Q9I7F7-1 ]
NP_477087.3. NM_057739.4.
UniGenei Dm.4488.

3D structure databases

ProteinModelPortali Q9I7F7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7227.FBpp0086889.

Proteomic databases

PaxDbi Q9I7F7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0330329 ; FBpp0303361 ; FBgn0263998 . [Q9I7F7-1 ]
GeneIDi 36442.
KEGGi dme:Dmel_CG43741.

Organism-specific databases

CTDi 36442.
FlyBasei FBgn0013955. PR2.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118799.
InParanoidi Q9I7F7.
PhylomeDBi Q9I7F7.

Miscellaneous databases

GenomeRNAii 36442.
NextBioi 798590.

Gene expression databases

Bgeei Q9I7F7.
ExpressionAtlasi Q9I7F7. differential.

Family and domain databases

Gene3Di 3.90.810.10. 1 hit.
InterProi IPR000095. CRIB_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF00786. PBD. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view ]
SMARTi SM00285. PBD. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50108. CRIB. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
    Strain: Berkeley.
    Tissue: Embryo.
  4. "Alternative splicing generates two distinct transcripts for the Drosophila melanogaster fibroblast growth factor receptor homolog."
    Ito M., Matsui T., Taniguchi T., Chihara K.
    Gene 139:215-218(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-917 (ISOFORM LONG).
    Strain: Oregon-R.
    Tissue: Embryo.
  5. "Sampling the genomic pool of protein tyrosine kinase genes using the polymerase chain reaction with genomic DNA."
    Oates A.C., Wollberg P., Achen M.G., Wilks A.F.
    Biochem. Biophys. Res. Commun. 249:660-667(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 266-321.
  6. "An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells."
    Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A.
    Mol. Biosyst. 3:275-286(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-831, IDENTIFICATION BY MASS SPECTROMETRY.
  7. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71; TYR-291; TYR-292; SER-764; SER-778; SER-918 AND SER-924, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiPR2_DROME
AccessioniPrimary (citable) accession number: Q9I7F7
Secondary accession number(s): Q24316, Q960Z6, Q9V6K0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: January 27, 2003
Last modified: November 26, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3