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Protein

Tyrosine-protein kinase PR2

Gene

PR2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei164ATPPROSITE-ProRule annotation1
Active sitei260Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi139 – 147ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase PR2 (EC:2.7.10.2)
Gene namesi
Name:PR2
ORF Names:CG3969
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0013955 PR2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000881321 – 1337Tyrosine-protein kinase PR2Add BLAST1337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei71Phosphoserine1 Publication1
Modified residuei291Phosphotyrosine1 Publication1
Modified residuei292Phosphotyrosine1 Publication1
Modified residuei764Phosphoserine1 Publication1
Modified residuei778Phosphoserine1 Publication1
Modified residuei831Phosphoserine1 Publication1
Modified residuei918Phosphoserine1 Publication1
Modified residuei924Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9I7F7
PRIDEiQ9I7F7

PTM databases

iPTMnetiQ9I7F7

Expressioni

Gene expression databases

BgeeiFBgn0263998
ExpressionAtlasiQ9I7F7 baseline and differential
GenevisibleiQ9I7F7 DM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi62210, 1 interactor
IntActiQ9I7F7, 3 interactors
STRINGi7227.FBpp0303364

Structurei

3D structure databases

ProteinModelPortaliQ9I7F7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 399Protein kinasePROSITE-ProRule annotationAdd BLAST267
Domaini399 – 460SH3PROSITE-ProRule annotationAdd BLAST62
Domaini488 – 502CRIBPROSITE-ProRule annotationAdd BLAST15

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG0199 Eukaryota
ENOG410XPRC LUCA
GeneTreeiENSGT00760000118799
InParanoidiQ9I7F7
OMAiEMHWRQM
PhylomeDBiQ9I7F7

Family and domain databases

CDDicd00132 CRIB, 1 hit
InterProiView protein in InterPro
IPR000095 CRIB_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF00786 PBD, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00285 PBD, 1 hit
SM00326 SH3, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9I7F7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYPQIDLYE FLTESELQQY YNAVKNELKI TNAAQFKYAA DEDLRFIGLS
60 70 80 90 100
RPEIRRLRKF YEKHFPHSYL SKIKRLLQAP GTMVKREEAP GGGSQVALDG
110 120 130 140 150
SSASACSSLA AKNGASSPSK VPNNKHIIPA DSISVNKQLG TGEFGIVQQG
160 170 180 190 200
VWSNGNERIQ VAIKCLCRER MQSNPMEFLK EAAIMHSIEH ENIVRLYGVV
210 220 230 240 250
LATDSLMLVT ELAHLRSLLE CLKDSGLRVS FLTIPTLCEF ALQICNGMRY
260 270 280 290 300
LEQKRLIHRD LAARNILVFS KDKVKISDFG LSRALGVGKD YYKTNFNVNL
310 320 330 340 350
KLPIAWCAPE CINYLRFTNA SDVWAFGVCL WEMFSYGFQP WAALTGLQIL
360 370 380 390 400
EAIDAPNYQR LEQPDCCPSE YYTLMMKCWQ DDAAKRPRFG EIYDQLPDMK
410 420 430 440 450
PEQLKAVVNC TEPKKDHLLY RQGDIISVLD RNTGTPFWKG VLSTGKTGYF
460 470 480 490 500
NPSNTVAFLE GLPSSTRDSF SRVSDHRISK RKLRTEMISK PQNDFKHTGH
510 520 530 540 550
VGIDGATFGD IAFLGSSQNY NHVPKQIVTP YKPSEDIEQT PLLLPPTPTS
560 570 580 590 600
PDSLQTASGY FPEGANSGGA MGTSMNPTFI PSAEHTPKLI ATNGQSSFDF
610 620 630 640 650
ASGSTNPFFP NRGDDELEFG LHNYGADGKS VHSETGWRPT SRSIVDDPHE
660 670 680 690 700
YHEISDDEIA ADKLDFGPSL LDEINSMFGS ISAATGSHPK SPGFDHVNNK
710 720 730 740 750
NEITEMSAKL GQKSGDTNGN KHGHGLLPTL SKKKSSGTVK PISVKDEKIL
760 770 780 790 800
NHAIEIANEI SARSMIDLVS DQTPVIHSPK RKFSFRFPHL SNNGSGDKSG
810 820 830 840 850
GLGTSGSAHT PTHGNASPFP KKKNFTEELQ SIPDIQSLIG KEGLEAYNSL
860 870 880 890 900
IERKALLDIG PSPAATLLRH LDTDEFDLQS LHQSQRPMTL PTRGATQRVR
910 920 930 940 950
KAELAAGLSR HNDENSNSLE ACESPSYMTH GSYKFPEAQP TEQLPEPESP
960 970 980 990 1000
NPIPLPPREG KKQVKTSTKR HVRKYPLIIP ANGLQRTLSK LADFGDEAAK
1010 1020 1030 1040 1050
SPEISTSSQP QPGRAIEVVA AVRPSGMRRP SRPSEREYEN MPTVGKESAH
1060 1070 1080 1090 1100
TYQNLDKLTP ADAAGLTDTA SLQFESIMEA DTSKEGILQS PDVTDGFYNF
1110 1120 1130 1140 1150
SIQKEHYNKG KDAEFEATQI SGLYVNDDEL RNLDIESSRR TATPCSSCSA
1160 1170 1180 1190 1200
LESEHSQPDA LPSTESVSEV SRFSSVDNEL AGNALFKKVR ASVNMAMNRK
1210 1220 1230 1240 1250
SVAETSLTSN QPGGASAKPQ TEAEYFAATA ARLADSNSVS CEDLLEFSDK
1260 1270 1280 1290 1300
KPKGCERGVD SDEVRIMVKV LGKDSTPNRC LGALEFINWD VHKSIKLIKL
1310 1320 1330
QNLVSEANLS LEASFEALQQ HEWDLHTTAH KLNGLKL
Length:1,337
Mass (Da):147,477
Last modified:January 27, 2003 - v3
Checksum:i12650E9DF5A82724
GO

Sequence cautioni

The sequence AAF58423 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA04489 differs from that shown. Reason: Frameshift at positions 752, 806, 816 and 827.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti450F → FSTPFWKGVLSTGKTGYF in BAA04489 (PubMed:8112607).Curated1
Sequence conflicti484R → A in BAA04489 (PubMed:8112607).Curated1
Sequence conflicti906A → P in BAA04489 (PubMed:8112607).Curated1
Sequence conflicti913D → V in BAA04489 (PubMed:8112607).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58423.5 Sequence problems.
AE013599 Genomic DNA Translation: AAG22275.3
AY051755 mRNA Translation: AAK93179.1
D17551 mRNA Translation: BAA04489.1 Frameshift.
AJ002909 Genomic DNA Translation: CAA05744.1
RefSeqiNP_477086.2, NM_057738.4
NP_477087.3, NM_057739.4
UniGeneiDm.4488

Genome annotation databases

EnsemblMetazoaiFBtr0330329; FBpp0303361; FBgn0263998
GeneIDi36442
KEGGidme:Dmel_CG43741

Similar proteinsi

Entry informationi

Entry nameiPR2_DROME
AccessioniPrimary (citable) accession number: Q9I7F7
Secondary accession number(s): Q24316, Q960Z6, Q9V6K0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: January 27, 2003
Last modified: May 23, 2018
This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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