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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi219 – 226ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-1-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaA
Gene namesi
Name:dnaA
Ordered Locus Names:PA0001
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA0001

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001142381 – 514Chromosomal replication initiator protein DnaAAdd BLAST514

Proteomic databases

PaxDbiQ9I7C5

Interactioni

Protein-protein interaction databases

STRINGi208964.PA0001

Structurei

3D structure databases

ProteinModelPortaliQ9I7C5
SMRiQ9I7C5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.Curated

Phylogenomic databases

eggNOGiENOG4105CI4 Bacteria
COG0593 LUCA
InParanoidiQ9I7C5
KOiK02313
OMAiREFNPLF
PhylomeDBiQ9I7C5

Family and domain databases

CDDicd06571 Bac_DnaA_C, 1 hit
Gene3Di1.10.1750.10, 1 hit
3.30.300.180, 1 hit
HAMAPiMF_00377 DnaA_bact, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR001957 Chromosome_initiator_DnaA
IPR020591 Chromosome_initiator_DnaA-like
IPR018312 Chromosome_initiator_DnaA_CS
IPR013317 DnaA
IPR013159 DnaA_C
IPR024633 DnaA_N_dom
IPR038454 DnaA_N_sf
IPR027417 P-loop_NTPase
IPR010921 Trp_repressor/repl_initiator
PANTHERiPTHR30050:SF2 PTHR30050:SF2, 1 hit
PfamiView protein in Pfam
PF00308 Bac_DnaA, 1 hit
PF08299 Bac_DnaA_C, 1 hit
PF11638 DnaA_N, 1 hit
PRINTSiPR00051 DNAA
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00760 Bac_DnaA_C, 1 hit
SUPFAMiSSF48295 SSF48295, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00362 DnaA, 1 hit
PROSITEiView protein in PROSITE
PS01008 DNAA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9I7C5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVELWQQCV DLLRDELPSQ QFNTWIRPLQ VEAEGDELRV YAPNRFVLDW
60 70 80 90 100
VNEKYLGRLL ELLGERGEGQ LPALSLLIGS KRSRTPRAAI VPSQTHVAPP
110 120 130 140 150
PPVAPPPAPV QPVSAAPVVV PREELPPVTT APSVSSDPYE PEEPSIDPLA
160 170 180 190 200
AAMPAGAAPA VRTERNVQVE GALKHTSYLN RTFTFENFVE GKSNQLARAA
210 220 230 240 250
AWQVADNLKH GYNPLFLYGG VGLGKTHLMH AVGNHLLKKN PNAKVVYLHS
260 270 280 290 300
ERFVADMVKA LQLNAINEFK RFYRSVDALL IDDIQFFARK ERSQEEFFHT
310 320 330 340 350
FNALLEGGQQ VILTSDRYPK EIEGLEERLK SRFGWGLTVA VEPPELETRV
360 370 380 390 400
AILMKKAEQA KIELPHDAAF FIAQRIRSNV RELEGALKRV IAHSHFMGRP
410 420 430 440 450
ITIELIRESL KDLLALQDKL VSIDNIQRTV AEYYKIKISD LLSKRRSRSV
460 470 480 490 500
ARPRQVAMAL SKELTNHSLP EIGVAFGGRD HTTVLHACRK IAQLRESDAD
510
IREDYKNLLR TLTT
Length:514
Mass (Da):57,754
Last modified:March 1, 2001 - v1
Checksum:iACEE3916221E2E84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229442 Genomic DNA Translation: AAG28797.1
AE004091 Genomic DNA Translation: AAG03391.1
PIRiE83644
RefSeqiNP_064721.1, NC_002516.2
WP_003109151.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG03391; AAG03391; PA0001
GeneIDi878417
KEGGipae:PA0001
PATRICifig|208964.12.peg.1

Similar proteinsi

Entry informationi

Entry nameiDNAA_PSEAE
AccessioniPrimary (citable) accession number: Q9I7C5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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