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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi219 – 226ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaA
Gene namesi
Name:dnaA
Ordered Locus Names:PA0001
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA0001.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001142381 – 514Chromosomal replication initiator protein DnaAAdd BLAST514

Proteomic databases

PaxDbiQ9I7C5.
PRIDEiQ9I7C5.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA0001.

Structurei

3D structure databases

ProteinModelPortaliQ9I7C5.
SMRiQ9I7C5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.Curated

Phylogenomic databases

eggNOGiENOG4105CI4. Bacteria.
COG0593. LUCA.
InParanoidiQ9I7C5.
KOiK02313.
OMAiPIEYENC.
PhylomeDBiQ9I7C5.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR024633. DnaA_N_dom.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PF11638. DnaA_N. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9I7C5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVELWQQCV DLLRDELPSQ QFNTWIRPLQ VEAEGDELRV YAPNRFVLDW
60 70 80 90 100
VNEKYLGRLL ELLGERGEGQ LPALSLLIGS KRSRTPRAAI VPSQTHVAPP
110 120 130 140 150
PPVAPPPAPV QPVSAAPVVV PREELPPVTT APSVSSDPYE PEEPSIDPLA
160 170 180 190 200
AAMPAGAAPA VRTERNVQVE GALKHTSYLN RTFTFENFVE GKSNQLARAA
210 220 230 240 250
AWQVADNLKH GYNPLFLYGG VGLGKTHLMH AVGNHLLKKN PNAKVVYLHS
260 270 280 290 300
ERFVADMVKA LQLNAINEFK RFYRSVDALL IDDIQFFARK ERSQEEFFHT
310 320 330 340 350
FNALLEGGQQ VILTSDRYPK EIEGLEERLK SRFGWGLTVA VEPPELETRV
360 370 380 390 400
AILMKKAEQA KIELPHDAAF FIAQRIRSNV RELEGALKRV IAHSHFMGRP
410 420 430 440 450
ITIELIRESL KDLLALQDKL VSIDNIQRTV AEYYKIKISD LLSKRRSRSV
460 470 480 490 500
ARPRQVAMAL SKELTNHSLP EIGVAFGGRD HTTVLHACRK IAQLRESDAD
510
IREDYKNLLR TLTT
Length:514
Mass (Da):57,754
Last modified:March 1, 2001 - v1
Checksum:iACEE3916221E2E84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229442 Genomic DNA. Translation: AAG28797.1.
AE004091 Genomic DNA. Translation: AAG03391.1.
PIRiE83644.
RefSeqiNP_064721.1. NC_002516.2.
WP_003109151.1. NZ_ASJY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAG03391; AAG03391; PA0001.
GeneIDi878417.
KEGGipae:PA0001.
PATRICi19834198. VBIPseAer58763_0001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229442 Genomic DNA. Translation: AAG28797.1.
AE004091 Genomic DNA. Translation: AAG03391.1.
PIRiE83644.
RefSeqiNP_064721.1. NC_002516.2.
WP_003109151.1. NZ_ASJY01000001.1.

3D structure databases

ProteinModelPortaliQ9I7C5.
SMRiQ9I7C5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA0001.

Proteomic databases

PaxDbiQ9I7C5.
PRIDEiQ9I7C5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG03391; AAG03391; PA0001.
GeneIDi878417.
KEGGipae:PA0001.
PATRICi19834198. VBIPseAer58763_0001.

Organism-specific databases

PseudoCAPiPA0001.

Phylogenomic databases

eggNOGiENOG4105CI4. Bacteria.
COG0593. LUCA.
InParanoidiQ9I7C5.
KOiK02313.
OMAiPIEYENC.
PhylomeDBiQ9I7C5.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR024633. DnaA_N_dom.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PF11638. DnaA_N. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAA_PSEAE
AccessioniPrimary (citable) accession number: Q9I7C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.