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Q9I6V6

- Q9I6V6_PSEAE

UniProt

Q9I6V6 - Q9I6V6_PSEAE

Protein
Submitted name:

Aerotaxis transducer Aer2

Gene

aer2

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi234 – 2341Iron (heme 1 axial ligand); via tele nitrogen
    Metal bindingi234 – 2341Iron (heme 2 axial ligand); via tele nitrogenImported

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. signal transducer activity Source: InterPro

    GO - Biological processi

    1. aerotaxis Source: PseudoCAP

    Keywords - Ligandi

    HemeImported, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Aerotaxis transducer Aer2Imported
    Gene namesi
    Name:aer2Imported
    Ordered Locus Names:PA0176Imported
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)Imported
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA0176.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: InterPro

    Interactioni

    Protein-protein interaction databases

    STRINGi208964.PA0176.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3LNRX-ray2.64A1-172[»]
    3VOLX-ray2.40A173-384[»]
    4HI4X-ray2.30A/B/D/G174-289[»]
    4I3MX-ray1.95A1-172[»]
    4I44X-ray2.88A1-172[»]
    ProteinModelPortaliQ9I6V6.
    SMRiQ9I6V6. Positions 1-157, 169-306, 334-634.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9I6V6.

    Family & Domainsi

    Phylogenomic databases

    KOiK03406.
    OMAiNASCSEE.
    OrthoDBiEOG6G4VQG.
    PhylomeDBiQ9I6V6.

    Family and domain databases

    InterProiIPR004090. Chemotax_Me-accpt_rcpt.
    IPR003660. HAMP_linker_domain.
    IPR004089. MCPsignal_dom.
    IPR000014. PAS.
    [Graphical view]
    PfamiPF00015. MCPsignal. 1 hit.
    PF13188. PAS_8. 1 hit.
    [Graphical view]
    PRINTSiPR00260. CHEMTRNSDUCR.
    SMARTiSM00304. HAMP. 2 hits.
    SM00283. MA. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF55785. SSF55785. 1 hit.
    PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
    PS50885. HAMP. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9I6V6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLFNAHAVA QQRADRIATL LQSFADGQLD TAVGEAPAPG YERLYDSLRA    50
    LQRQLREQRA ELQQVESLEA GLAEMSRQHE AGWIDQTIPA ERLEGRAARI 100
    AKGVNELVAA HIAVKMKVVS VVTAYGQGNF EPLMDRLPGK KAQITEAIDG 150
    VRERLRGAAE ATSAQLATAA YNARIKSALD NVSANVMIAD NDLNIIYMNR 200
    TVSEMLGRAE ADIRKQLPNF DAGRLMGANI DVFHKNPAHQ RHLLANLTGV 250
    HKAELNLGGR RFSLDVVPVF NDANERLGSA VQWTDRTEEH RAEQEVSQLV 300
    QAAAAGDFSK RVEEAGKEGF FLRLAKDLNS LVDTADRGLR DVSRMLGALA 350
    QGDLTQRIEA DYQGTFGQLK DFSNDTAQSL SRMLGQIREA ADTINTAASE 400
    IASGNAELSA RTEQQASSLE ETASSMEELT STVKLNAENA RQANSLAANA 450
    SEVATQGGTV VQKVVSTMSS INESARKIAD IIGVIDGIAF QTNILALNAA 500
    VEAARAGEQG RGFAVVAGEV RTLAQRSAAA AKEIKTLISD SVDKVENGNT 550
    LVAQAGQTMS DIVVAIRRVT DIMSEIAAAS AEQSTGIEEV NSAVSQMDDM 600
    TQQNAALVEE AAAAAEAMQE QAGLLNQSVA VFRLDTPPSV VQLASARPSA 650
    PRPSAPAPLA RSGMARASKA RKEDGWEEF 679
    Length:679
    Mass (Da):72,591
    Last modified:March 1, 2001 - v1
    Checksum:i246EF0D775120272
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG03566.1.
    PIRiA83624.
    RefSeqiNP_248866.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG03566; AAG03566; PA0176.
    GeneIDi882219.
    KEGGipae:PA0176.
    PATRICi19834560. VBIPseAer58763_0182.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG03566.1 .
    PIRi A83624.
    RefSeqi NP_248866.1. NC_002516.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3LNR X-ray 2.64 A 1-172 [» ]
    3VOL X-ray 2.40 A 173-384 [» ]
    4HI4 X-ray 2.30 A/B/D/G 174-289 [» ]
    4I3M X-ray 1.95 A 1-172 [» ]
    4I44 X-ray 2.88 A 1-172 [» ]
    ProteinModelPortali Q9I6V6.
    SMRi Q9I6V6. Positions 1-157, 169-306, 334-634.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208964.PA0176.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG03566 ; AAG03566 ; PA0176 .
    GeneIDi 882219.
    KEGGi pae:PA0176.
    PATRICi 19834560. VBIPseAer58763_0182.

    Organism-specific databases

    PseudoCAPi PA0176.

    Phylogenomic databases

    KOi K03406.
    OMAi NASCSEE.
    OrthoDBi EOG6G4VQG.
    PhylomeDBi Q9I6V6.

    Miscellaneous databases

    EvolutionaryTracei Q9I6V6.

    Family and domain databases

    InterProi IPR004090. Chemotax_Me-accpt_rcpt.
    IPR003660. HAMP_linker_domain.
    IPR004089. MCPsignal_dom.
    IPR000014. PAS.
    [Graphical view ]
    Pfami PF00015. MCPsignal. 1 hit.
    PF13188. PAS_8. 1 hit.
    [Graphical view ]
    PRINTSi PR00260. CHEMTRNSDUCR.
    SMARTi SM00304. HAMP. 2 hits.
    SM00283. MA. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55785. SSF55785. 1 hit.
    PROSITEi PS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
    PS50885. HAMP. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228Imported.
    2. "Structure of concatenated HAMP domains provides a mechanism for signal transduction."
      Airola M.V., Watts K.J., Bilwes A.M., Crane B.R.
      Structure 18:436-448(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.64 ANGSTROMS) OF 1-172.
    3. "Structural basis for oxygen sensing and signal transduction of the heme-based sensor protein Aer2 from Pseudomonas aeruginosa."
      Sawai H., Sugimoto H., Shiro Y., Ishikawa H., Mizutani Y., Aono S.
      Chem. Commun. (Camb.) 48:6523-6525(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 173-384 IN COMPLEX WITH HEME.
    4. "Architecture of the soluble receptor Aer2 indicates an in-line mechanism for PAS and HAMP domain signaling."
      Airola M.V., Huh D., Sukomon N., Widom J., Sircar R., Borbat P.P., Freed J.H., Watts K.J., Crane B.R.
      J. Mol. Biol. 425:886-901(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 174-289 IN COMPLEX WITH HEME.
    5. "HAMP domain conformers that propagate opposite signals in bacterial chemoreceptors."
      Airola M.V., Sukomon N., Samanta D., Borbat P.P., Freed J.H., Watts K.J., Crane B.R.
      PLoS Biol. 11:e1001479-e1001479(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 1-172.

    Entry informationi

    Entry nameiQ9I6V6_PSEAE
    AccessioniPrimary (citable) accession number: Q9I6V6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3