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Protein
Submitted name:

Aerotaxis transducer Aer2

Gene

aer2

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi234 – 2341Iron (heme 2 axial ligand); via tele nitrogenCombined sources

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. signal transducer activity Source: InterPro

GO - Biological processi

  1. aerotaxis Source: PseudoCAP
Complete GO annotation...

Keywords - Ligandi

HemeCombined sources, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Aerotaxis transducer Aer2Imported
Gene namesi
Name:aer2Imported
Ordered Locus Names:PA0176Imported
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)Imported
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA0176.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi208964.PA0176.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LNRX-ray2.64A1-172[»]
3VOLX-ray2.40A173-384[»]
4HI4X-ray2.30A/B/D/G174-289[»]
4I3MX-ray1.95A1-172[»]
4I44X-ray2.88A1-172[»]
ProteinModelPortaliQ9I6V6.
SMRiQ9I6V6. Positions 1-157, 169-306, 334-634.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9I6V6.

Family & Domainsi

Phylogenomic databases

InParanoidiQ9I6V6.
KOiK03406.
OMAiEMSEIVQ.
OrthoDBiEOG6G4VQG.
PhylomeDBiQ9I6V6.

Family and domain databases

InterProiIPR004090. Chemotax_Me-accpt_rcpt.
IPR003660. HAMP_linker_domain.
IPR004089. MCPsignal_dom.
IPR000014. PAS.
[Graphical view]
PfamiPF00015. MCPsignal. 1 hit.
PF13188. PAS_8. 1 hit.
[Graphical view]
PRINTSiPR00260. CHEMTRNSDUCR.
SMARTiSM00304. HAMP. 2 hits.
SM00283. MA. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF55785. SSF55785. 1 hit.
PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9I6V6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLFNAHAVA QQRADRIATL LQSFADGQLD TAVGEAPAPG YERLYDSLRA
60 70 80 90 100
LQRQLREQRA ELQQVESLEA GLAEMSRQHE AGWIDQTIPA ERLEGRAARI
110 120 130 140 150
AKGVNELVAA HIAVKMKVVS VVTAYGQGNF EPLMDRLPGK KAQITEAIDG
160 170 180 190 200
VRERLRGAAE ATSAQLATAA YNARIKSALD NVSANVMIAD NDLNIIYMNR
210 220 230 240 250
TVSEMLGRAE ADIRKQLPNF DAGRLMGANI DVFHKNPAHQ RHLLANLTGV
260 270 280 290 300
HKAELNLGGR RFSLDVVPVF NDANERLGSA VQWTDRTEEH RAEQEVSQLV
310 320 330 340 350
QAAAAGDFSK RVEEAGKEGF FLRLAKDLNS LVDTADRGLR DVSRMLGALA
360 370 380 390 400
QGDLTQRIEA DYQGTFGQLK DFSNDTAQSL SRMLGQIREA ADTINTAASE
410 420 430 440 450
IASGNAELSA RTEQQASSLE ETASSMEELT STVKLNAENA RQANSLAANA
460 470 480 490 500
SEVATQGGTV VQKVVSTMSS INESARKIAD IIGVIDGIAF QTNILALNAA
510 520 530 540 550
VEAARAGEQG RGFAVVAGEV RTLAQRSAAA AKEIKTLISD SVDKVENGNT
560 570 580 590 600
LVAQAGQTMS DIVVAIRRVT DIMSEIAAAS AEQSTGIEEV NSAVSQMDDM
610 620 630 640 650
TQQNAALVEE AAAAAEAMQE QAGLLNQSVA VFRLDTPPSV VQLASARPSA
660 670
PRPSAPAPLA RSGMARASKA RKEDGWEEF
Length:679
Mass (Da):72,591
Last modified:March 1, 2001 - v1
Checksum:i246EF0D775120272
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG03566.1.
PIRiA83624.
RefSeqiNP_248866.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG03566; AAG03566; PA0176.
GeneIDi882219.
KEGGipae:PA0176.
PATRICi19834560. VBIPseAer58763_0182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG03566.1.
PIRiA83624.
RefSeqiNP_248866.1. NC_002516.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LNRX-ray2.64A1-172[»]
3VOLX-ray2.40A173-384[»]
4HI4X-ray2.30A/B/D/G174-289[»]
4I3MX-ray1.95A1-172[»]
4I44X-ray2.88A1-172[»]
ProteinModelPortaliQ9I6V6.
SMRiQ9I6V6. Positions 1-157, 169-306, 334-634.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA0176.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG03566; AAG03566; PA0176.
GeneIDi882219.
KEGGipae:PA0176.
PATRICi19834560. VBIPseAer58763_0182.

Organism-specific databases

PseudoCAPiPA0176.

Phylogenomic databases

InParanoidiQ9I6V6.
KOiK03406.
OMAiEMSEIVQ.
OrthoDBiEOG6G4VQG.
PhylomeDBiQ9I6V6.

Miscellaneous databases

EvolutionaryTraceiQ9I6V6.

Family and domain databases

InterProiIPR004090. Chemotax_Me-accpt_rcpt.
IPR003660. HAMP_linker_domain.
IPR004089. MCPsignal_dom.
IPR000014. PAS.
[Graphical view]
PfamiPF00015. MCPsignal. 1 hit.
PF13188. PAS_8. 1 hit.
[Graphical view]
PRINTSiPR00260. CHEMTRNSDUCR.
SMARTiSM00304. HAMP. 2 hits.
SM00283. MA. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF55785. SSF55785. 1 hit.
PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228Imported.
  2. "Structure of concatenated HAMP domains provides a mechanism for signal transduction."
    Airola M.V., Watts K.J., Bilwes A.M., Crane B.R.
    Structure 18:436-448(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.64 ANGSTROMS) OF 1-172.
  3. "Structural basis for oxygen sensing and signal transduction of the heme-based sensor protein Aer2 from Pseudomonas aeruginosa."
    Sawai H., Sugimoto H., Shiro Y., Ishikawa H., Mizutani Y., Aono S.
    Chem. Commun. (Camb.) 48:6523-6525(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 173-384 IN COMPLEX WITH HEME.
  4. "Architecture of the soluble receptor Aer2 indicates an in-line mechanism for PAS and HAMP domain signaling."
    Airola M.V., Huh D., Sukomon N., Widom J., Sircar R., Borbat P.P., Freed J.H., Watts K.J., Crane B.R.
    J. Mol. Biol. 425:886-901(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 174-289 IN COMPLEX WITH HEME.
  5. "HAMP domain conformers that propagate opposite signals in bacterial chemoreceptors."
    Airola M.V., Sukomon N., Samanta D., Borbat P.P., Freed J.H., Watts K.J., Crane B.R.
    PLoS Biol. 11:e1001479-e1001479(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 1-172.

Entry informationi

Entry nameiQ9I6V6_PSEAE
AccessioniPrimary (citable) accession number: Q9I6V6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: January 7, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.