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Q9I6V6

- Q9I6V6_PSEAE

UniProt

Q9I6V6 - Q9I6V6_PSEAE

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Protein
Submitted name: Aerotaxis transducer Aer2
Gene
aer2, PA0176
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi234 – 2341Iron (heme 1 axial ligand); via tele nitrogenImported
Metal bindingi234 – 2341Iron (heme 2 axial ligand); via tele nitrogenImported
Binding sitei283 – 2831CyanideImported

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. signal transducer activity Source: InterPro

GO - Biological processi

  1. aerotaxis Source: PseudoCAP
Complete GO annotation...

Keywords - Ligandi

HemeImported, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Aerotaxis transducer Aer2Imported
Gene namesi
Name:aer2Imported
Ordered Locus Names:PA0176Imported
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)Imported
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA0176.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi208964.PA0176.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LNRX-ray2.64A1-172[»]
3VOLX-ray2.40A173-384[»]
4HI4X-ray2.30A/B/D/G174-289[»]
4I3MX-ray1.95A1-172[»]
4I44X-ray2.88A1-172[»]
ProteinModelPortaliQ9I6V6.
SMRiQ9I6V6. Positions 1-157, 169-306, 334-634.

Miscellaneous databases

EvolutionaryTraceiQ9I6V6.

Family & Domainsi

Phylogenomic databases

KOiK03406.
OMAiNASCSEE.
OrthoDBiEOG6G4VQG.
PhylomeDBiQ9I6V6.

Family and domain databases

InterProiIPR004090. Chemotax_Me-accpt_rcpt.
IPR003660. HAMP_linker_domain.
IPR004089. MCPsignal_dom.
IPR000014. PAS.
[Graphical view]
PfamiPF00015. MCPsignal. 1 hit.
PF13188. PAS_8. 1 hit.
[Graphical view]
PRINTSiPR00260. CHEMTRNSDUCR.
SMARTiSM00304. HAMP. 2 hits.
SM00283. MA. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF55785. SSF55785. 1 hit.
PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9I6V6-1 [UniParc]FASTAAdd to Basket

« Hide

MGLFNAHAVA QQRADRIATL LQSFADGQLD TAVGEAPAPG YERLYDSLRA    50
LQRQLREQRA ELQQVESLEA GLAEMSRQHE AGWIDQTIPA ERLEGRAARI 100
AKGVNELVAA HIAVKMKVVS VVTAYGQGNF EPLMDRLPGK KAQITEAIDG 150
VRERLRGAAE ATSAQLATAA YNARIKSALD NVSANVMIAD NDLNIIYMNR 200
TVSEMLGRAE ADIRKQLPNF DAGRLMGANI DVFHKNPAHQ RHLLANLTGV 250
HKAELNLGGR RFSLDVVPVF NDANERLGSA VQWTDRTEEH RAEQEVSQLV 300
QAAAAGDFSK RVEEAGKEGF FLRLAKDLNS LVDTADRGLR DVSRMLGALA 350
QGDLTQRIEA DYQGTFGQLK DFSNDTAQSL SRMLGQIREA ADTINTAASE 400
IASGNAELSA RTEQQASSLE ETASSMEELT STVKLNAENA RQANSLAANA 450
SEVATQGGTV VQKVVSTMSS INESARKIAD IIGVIDGIAF QTNILALNAA 500
VEAARAGEQG RGFAVVAGEV RTLAQRSAAA AKEIKTLISD SVDKVENGNT 550
LVAQAGQTMS DIVVAIRRVT DIMSEIAAAS AEQSTGIEEV NSAVSQMDDM 600
TQQNAALVEE AAAAAEAMQE QAGLLNQSVA VFRLDTPPSV VQLASARPSA 650
PRPSAPAPLA RSGMARASKA RKEDGWEEF 679
Length:679
Mass (Da):72,591
Last modified:March 1, 2001 - v1
Checksum:i246EF0D775120272
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG03566.1.
PIRiA83624.
RefSeqiNP_248866.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG03566; AAG03566; PA0176.
GeneIDi882219.
KEGGipae:PA0176.
PATRICi19834560. VBIPseAer58763_0182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG03566.1 .
PIRi A83624.
RefSeqi NP_248866.1. NC_002516.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3LNR X-ray 2.64 A 1-172 [» ]
3VOL X-ray 2.40 A 173-384 [» ]
4HI4 X-ray 2.30 A/B/D/G 174-289 [» ]
4I3M X-ray 1.95 A 1-172 [» ]
4I44 X-ray 2.88 A 1-172 [» ]
ProteinModelPortali Q9I6V6.
SMRi Q9I6V6. Positions 1-157, 169-306, 334-634.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA0176.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG03566 ; AAG03566 ; PA0176 .
GeneIDi 882219.
KEGGi pae:PA0176.
PATRICi 19834560. VBIPseAer58763_0182.

Organism-specific databases

PseudoCAPi PA0176.

Phylogenomic databases

KOi K03406.
OMAi NASCSEE.
OrthoDBi EOG6G4VQG.
PhylomeDBi Q9I6V6.

Miscellaneous databases

EvolutionaryTracei Q9I6V6.

Family and domain databases

InterProi IPR004090. Chemotax_Me-accpt_rcpt.
IPR003660. HAMP_linker_domain.
IPR004089. MCPsignal_dom.
IPR000014. PAS.
[Graphical view ]
Pfami PF00015. MCPsignal. 1 hit.
PF13188. PAS_8. 1 hit.
[Graphical view ]
PRINTSi PR00260. CHEMTRNSDUCR.
SMARTi SM00304. HAMP. 2 hits.
SM00283. MA. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view ]
SUPFAMi SSF55785. SSF55785. 1 hit.
PROSITEi PS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
  2. "Structure of concatenated HAMP domains provides a mechanism for signal transduction."
    Airola M.V., Watts K.J., Bilwes A.M., Crane B.R.
    Structure 18:436-448(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.64 ANGSTROMS) OF 1-172.
  3. "Structural basis for oxygen sensing and signal transduction of the heme-based sensor protein Aer2 from Pseudomonas aeruginosa."
    Sawai H., Sugimoto H., Shiro Y., Ishikawa H., Mizutani Y., Aono S.
    Chem. Commun. (Camb.) 48:6523-6525(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 173-384 IN COMPLEX WITH CYANIDE AND HEME.
  4. "Architecture of the soluble receptor Aer2 indicates an in-line mechanism for PAS and HAMP domain signaling."
    Airola M.V., Huh D., Sukomon N., Widom J., Sircar R., Borbat P.P., Freed J.H., Watts K.J., Crane B.R.
    J. Mol. Biol. 425:886-901(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 174-289 IN COMPLEX WITH HEME.
  5. "HAMP domain conformers that propagate opposite signals in bacterial chemoreceptors."
    Airola M.V., Sukomon N., Samanta D., Borbat P.P., Freed J.H., Watts K.J., Crane B.R.
    PLoS Biol. 11:e1001479-e1001479(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 1-172.

Entry informationi

Entry nameiQ9I6V6_PSEAE
AccessioniPrimary (citable) accession number: Q9I6V6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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