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Q9I6Q8 (PCAB_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-carboxy-cis,cis-muconate cycloisomerase
EC=5.5.1.2
Alternative name(s):
3-carboxymuconate lactonizing enzyme
Short name=CMLE
Gene names
Name:pcaB
Ordered Locus Names:PA0230
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifier208964 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes an anti cycloisomerization By similarity.

Catalytic activity

2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = cis,cis-butadiene-1,2,4-tricarboxylate.

Pathway

Aromatic compound metabolism; beta-ketoadipate pathway; 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate: step 1/2.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the class-II fumarase/aspartase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

protocatechuate catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-carboxy-cis,cis-muconate cycloisomerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4594593-carboxy-cis,cis-muconate cycloisomerase
PRO_0000287772

Sequences

Sequence LengthMass (Da)Tools
Q9I6Q8 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: C43F6B3651F2D1D0

FASTA45949,121
        10         20         30         40         50         60 
MSDVPANQLF DAYFMAAPMR AVFSDRGRLQ GMLDFEAALA RAEARTGVVP ATAVAPIEAA 

        70         80         90        100        110        120 
CRAELYDPLA LAEAVATAGN SAIPLVKALG RQVAAGDAEA ERYVHLGATS QDAMDSGLVL 

       130        140        150        160        170        180 
QLRRALALLE QDLQRLAEVL ADQAERHADT PLAGRTWLQH ATPVTLGMKL AGLLGALTRH 

       190        200        210        220        230        240 
RQRLRELRPR LLVLQFGGAS GTLAALGEQA LPVAAALAEE LGLALPEQPW HTQRDRLVEF 

       250        260        270        280        290        300 
ASVLGLVAGS LGKFGRDVSL LMQTEAGEVF EPAGAGRGGS STMPHKRNPV SSAVLIAAAT 

       310        320        330        340        350        360 
RAPGLVSTLF AAMPQEHERS LGLWHAEWET LPELCCLVAG ALQQAIGLLE GLEVDAQRMR 

       370        380        390        400        410        420 
RNLGLTHGLV LAEAVSIALA RRIGREAAHH LVEQCCRRAV EQRRELRAVL GEEARVSAEL 

       430        440        450 
SGDELDRLLD PAHYLGQARA WVERALAEHH ALGFEPHPA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE004091 Genomic DNA. Translation: AAG03619.1.
PIRB83616.
RefSeqNP_248921.1. NC_002516.2.

3D structure databases

HSSPHSSP built from PDB template 1Q5N based on UniProtKB Q59092.
ProteinModelPortalQ9I6Q8.
SMRQ9I6Q8. Positions 7-450.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID881957.
GenomeReviewsGene locus PA0230 in contig AE004091_GR.
KEGGpae:PA0230.
PATRIC19834676. VBIPseAer58763_0240.

Organism-specific databases

PseudoCAPPA0230.

Phylogenomic databases

HOGENOMHBG499008.
OMAHRATPMI.
ProtClustDBPRK09053.

Enzyme and pathway databases

BioCycPAER208964:PA0230-MONOMER.

Family and domain databases

InterProIPR019468. AdenyloSucc_lyase_C.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR024083. L-Aspartase-like_N.
IPR022761. Lyase1_N.
IPR012789. Protocat_PcaB.
[Graphical view]
Gene3DG3DSA:1.10.275.10. G3DSA:1.10.275.10. 1 hit.
KOK01857.
PfamPF10397. ADSL_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SMARTSM00998. ADSL_C. 1 hit.
[Graphical view]
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR02426. Protocat_pcaB. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePCAB_PSEAE
AccessionPrimary (citable) accession number: Q9I6Q8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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