Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

UbiD-like decarboxylase

Gene

hudA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible decarboxylation of aromatic carboxylic acids (Probable). Attenuates the virulence of P.aeruginosa in a Drosophila model when overexpressed (PubMed:18591226).UniRule annotation1 Publication

Cofactori

Mn2+UniRule annotation1 Publication, prenyl-FMNUniRule annotationNote: Binds 1 prenylated FMN (prenyl-FMN) per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi188ManganeseUniRule annotation1 Publication1
Metal bindingi229ManganeseUniRule annotation1 Publication1
Active sitei278Proton donorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
UbiD-like decarboxylaseUniRule annotation1 Publication (EC:4.1.1.-UniRule annotation)
Alternative name(s):
Ferulic acid decarboxylase-like proteinUniRule annotation
Homologous to UbiD protein A1 Publication
Gene namesi
Name:hudA1 Publication
Ordered Locus Names:PA0254
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA0254.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004345251 – 496UbiD-like decarboxylaseAdd BLAST496

Proteomic databases

PaxDbiQ9I6N5.

Expressioni

Inductioni

Repressed by hudR.1 Publication

Interactioni

Subunit structurei

Homodimer.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi208964.PA0254.

Structurei

Secondary structure

1496
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1 – 6Combined sources6
Helixi8 – 17Combined sources10
Beta strandi21 – 24Combined sources4
Helixi33 – 44Combined sources12
Beta strandi48 – 51Combined sources4
Beta strandi62 – 65Combined sources4
Helixi74 – 76Combined sources3
Helixi79 – 82Combined sources4
Helixi83 – 85Combined sources3
Helixi93 – 105Combined sources13
Helixi118 – 120Combined sources3
Beta strandi121 – 125Combined sources5
Helixi126 – 128Combined sources3
Helixi131 – 133Combined sources3
Beta strandi147 – 157Combined sources11
Beta strandi164 – 168Combined sources5
Beta strandi171 – 175Combined sources5
Beta strandi178 – 180Combined sources3
Helixi188 – 198Combined sources11
Beta strandi203 – 210Combined sources8
Helixi213 – 219Combined sources7
Helixi229 – 232Combined sources4
Helixi233 – 237Combined sources5
Beta strandi242 – 245Combined sources4
Beta strandi247 – 249Combined sources3
Beta strandi252 – 254Combined sources3
Beta strandi258 – 273Combined sources16
Beta strandi281 – 283Combined sources3
Beta strandi288 – 300Combined sources13
Beta strandi305 – 308Combined sources4
Beta strandi312 – 316Combined sources5
Helixi317 – 320Combined sources4
Helixi322 – 336Combined sources15
Beta strandi340 – 345Combined sources6
Helixi348 – 350Combined sources3
Beta strandi353 – 359Combined sources7
Helixi361 – 366Combined sources6
Helixi371 – 383Combined sources13
Helixi388 – 390Combined sources3
Beta strandi393 – 398Combined sources6
Helixi406 – 416Combined sources11
Turni419 – 421Combined sources3
Beta strandi422 – 425Combined sources4
Helixi440 – 445Combined sources6
Beta strandi451 – 454Combined sources4
Helixi458 – 462Combined sources5
Beta strandi466 – 469Combined sources4
Helixi472 – 475Combined sources4
Helixi478 – 491Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IP2X-ray1.95A/B/C1-496[»]
4IWSX-ray2.30A/B/C/D1-496[»]
ProteinModelPortaliQ9I6N5.
SMRiQ9I6N5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni165 – 170prenyl-FMN bindingUniRule annotation6
Regioni187 – 188prenyl-FMN bindingUniRule annotation2

Sequence similaritiesi

Belongs to the UbiD family. UbiD-like/FDC subfamily.UniRule annotation1 Publication

Phylogenomic databases

eggNOGiENOG4105D3H. Bacteria.
COG0043. LUCA.
HOGENOMiHOG000217444.
InParanoidiQ9I6N5.
KOiK03182.
OMAiEGPMGEY.
PhylomeDBiQ9I6N5.

Family and domain databases

HAMAPiMF_01983. UbiD_FDC. 1 hit.
InterProiIPR012349. Split_barrel_FMN-bd.
IPR002830. UbiD.
IPR032903. UbiD/Fdc1.
[Graphical view]
PfamiPF01977. UbiD. 1 hit.
[Graphical view]
SUPFAMiSSF50475. SSF50475. 1 hit.
TIGRFAMsiTIGR00148. TIGR00148. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9I6N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRSALDFRH FVDHLRRQGD LVDVHTEVDA NLEIGAITRR VYERRAPAPL
60 70 80 90 100
FHNIRDSLPG ARVLGAPAGL RADRARAHSR LALHFGLPEH SGPRDIVAML
110 120 130 140 150
RAAMRAEPIA PRRLERGPVQ ENVWLGEQVD LTRFPVPLLH EQDGGRYFGT
160 170 180 190 200
YGFHVVQTPD GSWDSWSVGR LMLVDRNTLA GPTIPTQHIG IIREQWRRLG
210 220 230 240 250
KPTPWAMALG APPAALAAAG MPLPEGVSEA GYVGALVGEP VEVVRTQTNG
260 270 280 290 300
LWVPANTEIV LEGEISLDET ALEGPMGEYH GYSFPIGKPQ PLFHVHALSF
310 320 330 340 350
RDQPILPICV AGTPPEENHT IWGTMISAQL LDVAQNAGLP VDMVWCSYEA
360 370 380 390 400
ATCWAVLSID VQRLAALGTD AAAFAARVAE TVFGSHAGHL VPKLILVGND
410 420 430 440 450
IDVTEIDQVV WALATRAHPL HDHFAFPQIR DFPMVPYLDA EDKARGSGGR
460 470 480 490
LVINCLYPEQ FAGQMRAATA SFRHAYPTAL RRRVEERWSD YGFGDA
Length:496
Mass (Da):54,500
Last modified:March 1, 2001 - v1
Checksum:i6C8EB98074A5CD54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG03643.1.
PIRiD83614.
RefSeqiNP_248945.1. NC_002516.2.
WP_003115722.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG03643; AAG03643; PA0254.
GeneIDi881878.
KEGGipae:PA0254.
PATRICi19834724. VBIPseAer58763_0264.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG03643.1.
PIRiD83614.
RefSeqiNP_248945.1. NC_002516.2.
WP_003115722.1. NC_002516.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IP2X-ray1.95A/B/C1-496[»]
4IWSX-ray2.30A/B/C/D1-496[»]
ProteinModelPortaliQ9I6N5.
SMRiQ9I6N5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA0254.

Proteomic databases

PaxDbiQ9I6N5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG03643; AAG03643; PA0254.
GeneIDi881878.
KEGGipae:PA0254.
PATRICi19834724. VBIPseAer58763_0264.

Organism-specific databases

PseudoCAPiPA0254.

Phylogenomic databases

eggNOGiENOG4105D3H. Bacteria.
COG0043. LUCA.
HOGENOMiHOG000217444.
InParanoidiQ9I6N5.
KOiK03182.
OMAiEGPMGEY.
PhylomeDBiQ9I6N5.

Family and domain databases

HAMAPiMF_01983. UbiD_FDC. 1 hit.
InterProiIPR012349. Split_barrel_FMN-bd.
IPR002830. UbiD.
IPR032903. UbiD/Fdc1.
[Graphical view]
PfamiPF01977. UbiD. 1 hit.
[Graphical view]
SUPFAMiSSF50475. SSF50475. 1 hit.
TIGRFAMsiTIGR00148. TIGR00148. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFDC_PSEAE
AccessioniPrimary (citable) accession number: Q9I6N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2015
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.