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Protein

UbiD-like decarboxylase

Gene

hudA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible decarboxylation of aromatic carboxylic acids (Probable). Attenuates the virulence of P.aeruginosa in a Drosophila model when overexpressed (PubMed:18591226).UniRule annotation1 Publication

Cofactori

Mn2+UniRule annotation1 Publication, prenyl-FMNUniRule annotationNote: Binds 1 prenylated FMN (prenyl-FMN) per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi188 – 1881ManganeseUniRule annotation1 Publication
Metal bindingi229 – 2291ManganeseUniRule annotation1 Publication
Active sitei278 – 2781Proton donorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
UbiD-like decarboxylaseUniRule annotation1 Publication (EC:4.1.1.-UniRule annotation)
Alternative name(s):
Ferulic acid decarboxylase-like proteinUniRule annotation
Homologous to UbiD protein A1 Publication
Gene namesi
Name:hudA1 Publication
Ordered Locus Names:PA0254
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA0254.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496UbiD-like decarboxylasePRO_0000434525Add
BLAST

Proteomic databases

PaxDbiQ9I6N5.

Expressioni

Inductioni

Repressed by hudR.1 Publication

Interactioni

Subunit structurei

Homodimer.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi208964.PA0254.

Structurei

Secondary structure

496
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1 – 66Combined sources
Helixi8 – 1710Combined sources
Beta strandi21 – 244Combined sources
Helixi33 – 4412Combined sources
Beta strandi48 – 514Combined sources
Beta strandi62 – 654Combined sources
Helixi74 – 763Combined sources
Helixi79 – 824Combined sources
Helixi83 – 853Combined sources
Helixi93 – 10513Combined sources
Helixi118 – 1203Combined sources
Beta strandi121 – 1255Combined sources
Helixi126 – 1283Combined sources
Helixi131 – 1333Combined sources
Beta strandi147 – 15711Combined sources
Beta strandi164 – 1685Combined sources
Beta strandi171 – 1755Combined sources
Beta strandi178 – 1803Combined sources
Helixi188 – 19811Combined sources
Beta strandi203 – 2108Combined sources
Helixi213 – 2197Combined sources
Helixi229 – 2324Combined sources
Helixi233 – 2375Combined sources
Beta strandi242 – 2454Combined sources
Beta strandi247 – 2493Combined sources
Beta strandi252 – 2543Combined sources
Beta strandi258 – 27316Combined sources
Beta strandi281 – 2833Combined sources
Beta strandi288 – 30013Combined sources
Beta strandi305 – 3084Combined sources
Beta strandi312 – 3165Combined sources
Helixi317 – 3204Combined sources
Helixi322 – 33615Combined sources
Beta strandi340 – 3456Combined sources
Helixi348 – 3503Combined sources
Beta strandi353 – 3597Combined sources
Helixi361 – 3666Combined sources
Helixi371 – 38313Combined sources
Helixi388 – 3903Combined sources
Beta strandi393 – 3986Combined sources
Helixi406 – 41611Combined sources
Turni419 – 4213Combined sources
Beta strandi422 – 4254Combined sources
Helixi440 – 4456Combined sources
Beta strandi451 – 4544Combined sources
Helixi458 – 4625Combined sources
Beta strandi466 – 4694Combined sources
Helixi472 – 4754Combined sources
Helixi478 – 49114Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IP2X-ray1.95A/B/C1-496[»]
4IWSX-ray2.30A/B/C/D1-496[»]
ProteinModelPortaliQ9I6N5.
SMRiQ9I6N5. Positions 1-494.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni165 – 1706prenyl-FMN bindingUniRule annotation
Regioni187 – 1882prenyl-FMN bindingUniRule annotation

Sequence similaritiesi

Belongs to the UbiD family. UbiD-like/FDC subfamily.UniRule annotation1 Publication

Phylogenomic databases

eggNOGiENOG4105D3H. Bacteria.
COG0043. LUCA.
HOGENOMiHOG000217444.
InParanoidiQ9I6N5.
OMAiEGPMGEY.
OrthoDBiEOG6MPWT4.
PhylomeDBiQ9I6N5.

Family and domain databases

HAMAPiMF_01983. UbiD_FDC.
InterProiIPR012349. Split_barrel_FMN-bd.
IPR002830. UbiD.
IPR032903. UbiD/Fdc1.
[Graphical view]
PfamiPF01977. UbiD. 1 hit.
[Graphical view]
SUPFAMiSSF50475. SSF50475. 1 hit.
TIGRFAMsiTIGR00148. TIGR00148. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9I6N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRSALDFRH FVDHLRRQGD LVDVHTEVDA NLEIGAITRR VYERRAPAPL
60 70 80 90 100
FHNIRDSLPG ARVLGAPAGL RADRARAHSR LALHFGLPEH SGPRDIVAML
110 120 130 140 150
RAAMRAEPIA PRRLERGPVQ ENVWLGEQVD LTRFPVPLLH EQDGGRYFGT
160 170 180 190 200
YGFHVVQTPD GSWDSWSVGR LMLVDRNTLA GPTIPTQHIG IIREQWRRLG
210 220 230 240 250
KPTPWAMALG APPAALAAAG MPLPEGVSEA GYVGALVGEP VEVVRTQTNG
260 270 280 290 300
LWVPANTEIV LEGEISLDET ALEGPMGEYH GYSFPIGKPQ PLFHVHALSF
310 320 330 340 350
RDQPILPICV AGTPPEENHT IWGTMISAQL LDVAQNAGLP VDMVWCSYEA
360 370 380 390 400
ATCWAVLSID VQRLAALGTD AAAFAARVAE TVFGSHAGHL VPKLILVGND
410 420 430 440 450
IDVTEIDQVV WALATRAHPL HDHFAFPQIR DFPMVPYLDA EDKARGSGGR
460 470 480 490
LVINCLYPEQ FAGQMRAATA SFRHAYPTAL RRRVEERWSD YGFGDA
Length:496
Mass (Da):54,500
Last modified:March 1, 2001 - v1
Checksum:i6C8EB98074A5CD54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG03643.1.
PIRiD83614.
RefSeqiNP_248945.1. NC_002516.2.
WP_003115722.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG03643; AAG03643; PA0254.
GeneIDi881878.
KEGGipae:PA0254.
PATRICi19834724. VBIPseAer58763_0264.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG03643.1.
PIRiD83614.
RefSeqiNP_248945.1. NC_002516.2.
WP_003115722.1. NC_002516.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IP2X-ray1.95A/B/C1-496[»]
4IWSX-ray2.30A/B/C/D1-496[»]
ProteinModelPortaliQ9I6N5.
SMRiQ9I6N5. Positions 1-494.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA0254.

Proteomic databases

PaxDbiQ9I6N5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG03643; AAG03643; PA0254.
GeneIDi881878.
KEGGipae:PA0254.
PATRICi19834724. VBIPseAer58763_0264.

Organism-specific databases

PseudoCAPiPA0254.

Phylogenomic databases

eggNOGiENOG4105D3H. Bacteria.
COG0043. LUCA.
HOGENOMiHOG000217444.
InParanoidiQ9I6N5.
OMAiEGPMGEY.
OrthoDBiEOG6MPWT4.
PhylomeDBiQ9I6N5.

Family and domain databases

HAMAPiMF_01983. UbiD_FDC.
InterProiIPR012349. Split_barrel_FMN-bd.
IPR002830. UbiD.
IPR032903. UbiD/Fdc1.
[Graphical view]
PfamiPF01977. UbiD. 1 hit.
[Graphical view]
SUPFAMiSSF50475. SSF50475. 1 hit.
TIGRFAMsiTIGR00148. TIGR00148. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
  2. "Drosophila melanogaster-based screening for multihost virulence factors of Pseudomonas aeruginosa PA14 and identification of a virulence-attenuating factor, HudA."
    Kim S.H., Park S.Y., Heo Y.J., Cho Y.H.
    Infect. Immun. 76:4152-4162(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  3. "Structural insights into the UbiD protein family from the crystal structure of PA0254 from Pseudomonas aeruginosa."
    Jacewicz A., Izumi A., Brunner K., Schnell R., Schneider G.
    PLoS ONE 8:E63161-E63161(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) IN COMPLEX WITH MANGANESE, SUBUNIT.

Entry informationi

Entry nameiFDC_PSEAE
AccessioniPrimary (citable) accession number: Q9I6N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2015
Last sequence update: March 1, 2001
Last modified: March 16, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.