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Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotation

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotation

Pathway: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-5-phosphate isomerase A (rpiA)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei107 – 1071Proton acceptorUniRule annotation
Binding sitei125 – 1251SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)
Alternative name(s):
Phosphoriboisomerase AUniRule annotation
Short name:
PRIUniRule annotation
Gene namesi
Name:rpiAUniRule annotation
Ordered Locus Names:PA0330
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA0330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Ribose-5-phosphate isomerase APRO_0000158450Add
BLAST

Proteomic databases

PRIDEiQ9I6G1.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi208964.PA0330.

Structurei

Secondary structure

1
223
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1816Combined sources
Helixi19 – 213Combined sources
Beta strandi27 – 304Combined sources
Helixi34 – 4411Combined sources
Helixi45 – 495Combined sources
Beta strandi52 – 576Combined sources
Helixi58 – 669Combined sources
Helixi74 – 763Combined sources
Beta strandi80 – 856Combined sources
Beta strandi88 – 903Combined sources
Helixi104 – 11310Combined sources
Beta strandi114 – 1229Combined sources
Helixi123 – 1253Combined sources
Beta strandi128 – 1303Combined sources
Beta strandi135 – 1395Combined sources
Helixi141 – 1433Combined sources
Helixi144 – 15310Combined sources
Beta strandi157 – 1604Combined sources
Beta strandi171 – 1777Combined sources
Helixi183 – 1919Combined sources
Beta strandi196 – 2027Combined sources
Beta strandi208 – 2147Combined sources
Beta strandi217 – 2215Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4X84X-ray1.25A/B/C/D1-223[»]
ProteinModelPortaliQ9I6G1.
SMRiQ9I6G1. Positions 1-223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni32 – 354Substrate bindingUniRule annotation
Regioni85 – 884Substrate bindingUniRule annotation
Regioni98 – 1014Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0120.
InParanoidiQ9I6G1.
KOiK01807.
OMAiGACHVQE.
OrthoDBiEOG67MF61.
PhylomeDBiQ9I6G1.

Family and domain databases

HAMAPiMF_00170. Rib_5P_isom_A.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9I6G1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQDQLKQAV AQAAVDHILP HLDSKSIVGV GTGSTANFFI DALARHKAEF
60 70 80 90 100
DGAVASSEAT AKRLKEHGIP VYELNTVSEL EFYVDGADES NERLELIKGG
110 120 130 140 150
GAALTREKIV AAVAKTFICI ADASKLVPIL GQFPLPVEVI PMARSHVARQ
160 170 180 190 200
LVKLGGDPVY REGVLTDNGN IILDVHNLRI DSPVELEEKI NAIVGVVTNG
210 220
LFAARPADLL LLGTADGVKT LKA
Length:223
Mass (Da):23,721
Last modified:March 1, 2001 - v1
Checksum:iED096E8EB6AF5E37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG03719.1.
PIRiE83603.
RefSeqiNP_249021.1. NC_002516.2.
WP_003084386.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG03719; AAG03719; PA0330.
GeneIDi882171.
KEGGipae:PA0330.
PATRICi19834890. VBIPseAer58763_0346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG03719.1.
PIRiE83603.
RefSeqiNP_249021.1. NC_002516.2.
WP_003084386.1. NC_002516.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4X84X-ray1.25A/B/C/D1-223[»]
ProteinModelPortaliQ9I6G1.
SMRiQ9I6G1. Positions 1-223.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA0330.

Proteomic databases

PRIDEiQ9I6G1.

Protocols and materials databases

DNASUi882171.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG03719; AAG03719; PA0330.
GeneIDi882171.
KEGGipae:PA0330.
PATRICi19834890. VBIPseAer58763_0346.

Organism-specific databases

PseudoCAPiPA0330.

Phylogenomic databases

eggNOGiCOG0120.
InParanoidiQ9I6G1.
KOiK01807.
OMAiGACHVQE.
OrthoDBiEOG67MF61.
PhylomeDBiQ9I6G1.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412.

Family and domain databases

HAMAPiMF_00170. Rib_5P_isom_A.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiRPIA_PSEAE
AccessioniPrimary (citable) accession number: Q9I6G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2001
Last modified: May 27, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.