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Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotation

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-5-phosphate isomerase A (rpiA)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei107Proton acceptorUniRule annotation1
Binding sitei125SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)
Alternative name(s):
Phosphoriboisomerase AUniRule annotation
Short name:
PRIUniRule annotation
Gene namesi
Name:rpiAUniRule annotation
Ordered Locus Names:PA0330
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA0330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001584501 – 223Ribose-5-phosphate isomerase AAdd BLAST223

Proteomic databases

PaxDbiQ9I6G1.
PRIDEiQ9I6G1.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi208964.PA0330.

Structurei

Secondary structure

1223
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 18Combined sources16
Helixi19 – 21Combined sources3
Beta strandi27 – 30Combined sources4
Helixi34 – 44Combined sources11
Helixi45 – 49Combined sources5
Beta strandi52 – 57Combined sources6
Helixi58 – 66Combined sources9
Helixi74 – 76Combined sources3
Beta strandi80 – 85Combined sources6
Beta strandi88 – 90Combined sources3
Helixi104 – 113Combined sources10
Beta strandi114 – 122Combined sources9
Helixi123 – 125Combined sources3
Beta strandi128 – 130Combined sources3
Beta strandi135 – 139Combined sources5
Helixi141 – 143Combined sources3
Helixi144 – 153Combined sources10
Beta strandi157 – 160Combined sources4
Beta strandi171 – 177Combined sources7
Helixi183 – 191Combined sources9
Beta strandi196 – 202Combined sources7
Beta strandi208 – 214Combined sources7
Beta strandi217 – 221Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4X84X-ray1.25A/B/C/D1-223[»]
ProteinModelPortaliQ9I6G1.
SMRiQ9I6G1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni32 – 35Substrate bindingUniRule annotation4
Regioni85 – 88Substrate bindingUniRule annotation4
Regioni98 – 101Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E66. Bacteria.
COG0120. LUCA.
InParanoidiQ9I6G1.
KOiK01807.
OMAiGACHVQE.
PhylomeDBiQ9I6G1.

Family and domain databases

CDDicd01398. RPI_A. 1 hit.
HAMAPiMF_00170. Rib_5P_isom_A. 1 hit.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9I6G1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQDQLKQAV AQAAVDHILP HLDSKSIVGV GTGSTANFFI DALARHKAEF
60 70 80 90 100
DGAVASSEAT AKRLKEHGIP VYELNTVSEL EFYVDGADES NERLELIKGG
110 120 130 140 150
GAALTREKIV AAVAKTFICI ADASKLVPIL GQFPLPVEVI PMARSHVARQ
160 170 180 190 200
LVKLGGDPVY REGVLTDNGN IILDVHNLRI DSPVELEEKI NAIVGVVTNG
210 220
LFAARPADLL LLGTADGVKT LKA
Length:223
Mass (Da):23,721
Last modified:March 1, 2001 - v1
Checksum:iED096E8EB6AF5E37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG03719.1.
PIRiE83603.
RefSeqiNP_249021.1. NC_002516.2.
WP_003084386.1. NZ_ASJY01000065.1.

Genome annotation databases

EnsemblBacteriaiAAG03719; AAG03719; PA0330.
GeneIDi882171.
KEGGipae:PA0330.
PATRICi19834890. VBIPseAer58763_0346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG03719.1.
PIRiE83603.
RefSeqiNP_249021.1. NC_002516.2.
WP_003084386.1. NZ_ASJY01000065.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4X84X-ray1.25A/B/C/D1-223[»]
ProteinModelPortaliQ9I6G1.
SMRiQ9I6G1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA0330.

Proteomic databases

PaxDbiQ9I6G1.
PRIDEiQ9I6G1.

Protocols and materials databases

DNASUi882171.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG03719; AAG03719; PA0330.
GeneIDi882171.
KEGGipae:PA0330.
PATRICi19834890. VBIPseAer58763_0346.

Organism-specific databases

PseudoCAPiPA0330.

Phylogenomic databases

eggNOGiENOG4105E66. Bacteria.
COG0120. LUCA.
InParanoidiQ9I6G1.
KOiK01807.
OMAiGACHVQE.
PhylomeDBiQ9I6G1.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412.

Family and domain databases

CDDicd01398. RPI_A. 1 hit.
HAMAPiMF_00170. Rib_5P_isom_A. 1 hit.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRPIA_PSEAE
AccessioniPrimary (citable) accession number: Q9I6G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.