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Protein

Bis(5'-nucleosyl)-tetraphosphatase, symmetrical

Gene

apaH

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.By similarity

Catalytic activityi

P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical (EC:3.6.1.41)
Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase
Gene namesi
Name:apaH
Ordered Locus Names:PA0590
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA0590.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Bis(5'-nucleosyl)-tetraphosphatase, symmetricalPRO_0000198004Add
BLAST

Proteomic databases

PaxDbiQ9I5U7.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA0590.

Structurei

3D structure databases

ProteinModelPortaliQ9I5U7.
SMRiQ9I5U7. Positions 2-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Ap4A hydrolase family.Curated

Phylogenomic databases

eggNOGiENOG4105DDT. Bacteria.
COG0639. LUCA.
HOGENOMiHOG000251871.
InParanoidiQ9I5U7.
KOiK01525.
OMAiINAFTRM.
OrthoDBiEOG66B3WP.
PhylomeDBiQ9I5U7.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
HAMAPiMF_00199. ApaH.
InterProiIPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR00668. apaH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9I5U7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVYAVGDLQ GCLDPLKCLL ERVAFDPAKD RLWLVGDLVN RGPQSLETLR
60 70 80 90 100
FLYAMRESVV SVLGNHDLHL LAVAHKSERL KKSDTLREIL EAPDREPLLD
110 120 130 140 150
WLRRLPLLHY DEQRKVALVH AGIPPQWSLE KARLRAAEVE QALRDDQRLP
160 170 180 190 200
LFLDGMYGNE PAKWDKKLHG IDRLRVITNY FTRMRFCTED GKLDLKSKEG
210 220 230 240 250
LDTAPPGYAP WFSFPSRKTR GEKIIFGHWA ALEGHCDEPG LFALDTGCVW
260 270 280
GARMTLLNVD SGERLSCDCA EQRAPARPAA TPA
Length:283
Mass (Da):32,019
Last modified:March 1, 2001 - v1
Checksum:iB7F21AE147168459
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG03979.1.
PIRiF83571.
RefSeqiNP_249281.1. NC_002516.2.
WP_003113213.1. NZ_ASJY01000101.1.

Genome annotation databases

EnsemblBacteriaiAAG03979; AAG03979; PA0590.
GeneIDi880834.
KEGGipae:PA0590.
PATRICi19835452. VBIPseAer58763_0626.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG03979.1.
PIRiF83571.
RefSeqiNP_249281.1. NC_002516.2.
WP_003113213.1. NZ_ASJY01000101.1.

3D structure databases

ProteinModelPortaliQ9I5U7.
SMRiQ9I5U7. Positions 2-257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA0590.

Proteomic databases

PaxDbiQ9I5U7.

Protocols and materials databases

DNASUi880834.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG03979; AAG03979; PA0590.
GeneIDi880834.
KEGGipae:PA0590.
PATRICi19835452. VBIPseAer58763_0626.

Organism-specific databases

PseudoCAPiPA0590.

Phylogenomic databases

eggNOGiENOG4105DDT. Bacteria.
COG0639. LUCA.
HOGENOMiHOG000251871.
InParanoidiQ9I5U7.
KOiK01525.
OMAiINAFTRM.
OrthoDBiEOG66B3WP.
PhylomeDBiQ9I5U7.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
HAMAPiMF_00199. ApaH.
InterProiIPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR00668. apaH. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiAPAH_PSEAE
AccessioniPrimary (citable) accession number: Q9I5U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 1, 2001
Last modified: November 11, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.