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Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei71Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-763-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Gene namesi
Name:ungUniRule annotation
Ordered Locus Names:PA0750
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA0750

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001761271 – 231Uracil-DNA glycosylaseAdd BLAST231

Proteomic databases

PaxDbiQ9I5H9
PRIDEiQ9I5H9

Interactioni

Protein-protein interaction databases

STRINGi208964.PA0750

Structurei

3D structure databases

ProteinModelPortaliQ9I5H9
SMRiQ9I5H9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5S Bacteria
COG0692 LUCA
HOGENOMiHOG000229528
InParanoidiQ9I5H9
KOiK03648
OMAiQANGLCF
PhylomeDBiQ9I5H9

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.101 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9I5H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDNDDRIKL EASWKEALRE EFDKPYMKQL GEFLRQEKAA GKVIFPPGPL
60 70 80 90 100
IFNALNTTPL ENVKVVIIGQ DPYHGPGQAH GLCFSVQPGV PTPPSLQNIY
110 120 130 140 150
KELNRDLNIP IPNNGYLQRW AEQGVLLLNT SLTVEQAKAG SHANAGWQPF
160 170 180 190 200
TDRVIEVVNE RCERLVFLLW GSHAQSKQKL IDPQRHLILK SAHPSPLSAY
210 220 230
RGFLGNGHFS RTNKFLEQNG KTPIDWSLPD L
Length:231
Mass (Da):26,010
Last modified:March 1, 2001 - v1
Checksum:i53F2B36FF0D883A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG04139.1
PIRiC83551
RefSeqiNP_249441.1, NC_002516.2
WP_003106436.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG04139; AAG04139; PA0750
GeneIDi881872
KEGGipae:PA0750
PATRICifig|208964.12.peg.779

Similar proteinsi

Entry informationi

Entry nameiUNG_PSEAE
AccessioniPrimary (citable) accession number: Q9I5H9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: March 1, 2001
Last modified: February 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome