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Q9I5A5

- PTA_PSEAE

UniProt

Q9I5A5 - PTA_PSEAE

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Protein

Phosphate acetyltransferase

Gene
pta, PA0835
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in acetate metabolism. In combination with LdhA and AckA, allows fermentation of pyruvate, enhancing long-term survival under anaerobic conditions.1 Publication

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.1 Publication

Enzyme regulationi

Activity is increased under anaerobic growth conditions.1 Publication

Pathwayi

GO - Molecular functioni

  1. phosphate acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00340; UER00459.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Gene namesi
Name:pta
Ordered Locus Names:PA0835
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA0835.

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Decreased survival under anaerobic conditions.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 704704Phosphate acetyltransferasePRO_0000405549Add
BLAST

Proteomic databases

PRIDEiQ9I5A5.

Expressioni

Inductioni

The ackA-pta operon is induced under oxygen-limiting conditions by the oxygen regulator Anr and DNA-binding integration host factor.1 Publication

Interactioni

Subunit structurei

Homohexamer By similarity.

Protein-protein interaction databases

STRINGi208964.PA0835.

Structurei

3D structure databases

ProteinModelPortaliQ9I5A5.
SMRiQ9I5A5. Positions 394-698.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni379 – 704326Phosphate acetyltransferaseAdd
BLAST

Domaini

The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site By similarity.

Sequence similaritiesi

In the N-terminal section; belongs to the CobB/CobQ family.
In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.

Phylogenomic databases

eggNOGiCOG0280.
KOiK13788.
OMAiKPIAQPH.
OrthoDBiEOG6BKJ5W.
PhylomeDBiQ9I5A5.

Family and domain databases

Gene3Di3.40.1390.20. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR027417. P-loop_NTPase.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
IPR028979. Ser_kin/Pase_Hpr_N_like.
[Graphical view]
PfamiPF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF006107. PhpActrans_proteobac. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF75138. SSF75138. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9I5A5-1 [UniParc]FASTAAdd to Basket

« Hide

MHTFFIAPTG FGVGLTSISL GLLRALERAG LKVGFFKPIA QLHPGDLGPE    50
RSSELVARTH GLDTPKPLPL AQVERMLGDG QLDELLEEII SLYQRAAADK 100
DVVIVEGMVP TRHASYAARV NFHLAKSLDA EVILVSAPEN ETLTELTDRI 150
EIQAQLFGGP RDPKVLGVIL NKVRGEADAA NAEDGVADFA RRLTEHSPLL 200
RDDFRLIGCI PWQDELNAAR TRDIADLLSA RVINAGDYEQ RRVQKIVLCA 250
RAVPNTVQLL KPGVLVVTPG DRDDIILAAS LAAMNGVPLA GLLLCSDFPP 300
DPRIMELCRG ALQGGLPVLS VATGSYDTAT NLNRMNKEIP VDDRERAERV 350
TEFVAGHIDF EWLKQRCGTP RELRLSPPAF RYQVVQRAQK AGKRIVLPEG 400
SEPRTVQAAA ICQARGIARC VLLAKPEEVQ AVAQAQGIVL PEGLEIIDPD 450
LVRQRYVEPM VELRKGKGLN APMAEQQLED SVVLATMMLA LDEVDGLVSG 500
AIHTTASTIR PALQLIKTAP GYNLVSSVFF MLLPDQVLVY GDCAVNPDPS 550
ASDLAEIAVQ SAASAQAFGI PARVAMISYS TGDSGSGVDV DKVREATRLA 600
REQRPDLLID GPLQYDAAAI ASVGRQKAPN SPVAGQATVF IFPDLNTGNT 650
TYKAVQRSAD CVSVGPMLQG LRKPVNDLSR GALVEDIVYT IALTAIQADA 700
QAPA 704
Length:704
Mass (Da):75,697
Last modified:March 1, 2001 - v1
Checksum:iEEEF0FFDB388A88C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG04224.1.
PIRiC83541.
RefSeqiNP_249526.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG04224; AAG04224; PA0835.
GeneIDi882123.
KEGGipae:PA0835.
PATRICi19835948. VBIPseAer58763_0866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG04224.1 .
PIRi C83541.
RefSeqi NP_249526.1. NC_002516.2.

3D structure databases

ProteinModelPortali Q9I5A5.
SMRi Q9I5A5. Positions 394-698.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA0835.

Proteomic databases

PRIDEi Q9I5A5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG04224 ; AAG04224 ; PA0835 .
GeneIDi 882123.
KEGGi pae:PA0835.
PATRICi 19835948. VBIPseAer58763_0866.

Organism-specific databases

PseudoCAPi PA0835.

Phylogenomic databases

eggNOGi COG0280.
KOi K13788.
OMAi KPIAQPH.
OrthoDBi EOG6BKJ5W.
PhylomeDBi Q9I5A5.

Enzyme and pathway databases

UniPathwayi UPA00340 ; UER00459 .

Family and domain databases

Gene3Di 3.40.1390.20. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR027417. P-loop_NTPase.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
IPR028979. Ser_kin/Pase_Hpr_N_like.
[Graphical view ]
Pfami PF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view ]
PIRSFi PIRSF006107. PhpActrans_proteobac. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF75138. SSF75138. 1 hit.
TIGRFAMsi TIGR00651. pta. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
  2. "Long-term anaerobic survival of the opportunistic pathogen Pseudomonas aeruginosa via pyruvate fermentation."
    Eschbach M., Schreiber K., Trunk K., Buer J., Jahn D., Schobert M.
    J. Bacteriol. 186:4596-4604(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, INDUCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiPTA_PSEAE
AccessioniPrimary (citable) accession number: Q9I5A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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