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Protein

Phosphate acetyltransferase

Gene

pta

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in acetate metabolism. In combination with LdhA and AckA, allows fermentation of pyruvate, enhancing long-term survival under anaerobic conditions.1 Publication

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.1 Publication

Enzyme regulationi

Activity is increased under anaerobic growth conditions.1 Publication

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes acetyl-CoA from acetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-849-MONOMER
UniPathwayiUPA00340; UER00459

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Gene namesi
Name:pta
Ordered Locus Names:PA0835
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA0835

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Decreased survival under anaerobic conditions.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004055491 – 704Phosphate acetyltransferaseAdd BLAST704

Proteomic databases

PaxDbiQ9I5A5
PRIDEiQ9I5A5

Expressioni

Inductioni

The ackA-pta operon is induced under oxygen-limiting conditions by the oxygen regulator Anr and DNA-binding integration host factor.1 Publication

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi208964.PA0835

Structurei

3D structure databases

ProteinModelPortaliQ9I5A5
SMRiQ9I5A5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni379 – 704Phosphate acetyltransferaseAdd BLAST326

Domaini

The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site (By similarity).By similarity

Sequence similaritiesi

In the N-terminal section; belongs to the CobB/CobQ family.Curated
In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.Curated

Phylogenomic databases

eggNOGiENOG4105C6K Bacteria
COG0280 LUCA
COG0857 LUCA
InParanoidiQ9I5A5
KOiK13788
OMAiTPLMFEY
PhylomeDBiQ9I5A5

Family and domain databases

Gene3Di3.40.1390.20, 1 hit
InterProiView protein in InterPro
IPR010766 DRTGG
IPR016475 P-Actrans_bac
IPR027417 P-loop_NTPase
IPR004614 P_AcTrfase
IPR002505 PTA_PTB
IPR028979 Ser_kin/Pase_Hpr-like_N_sf
PfamiView protein in Pfam
PF07085 DRTGG, 1 hit
PF01515 PTA_PTB, 1 hit
PIRSFiPIRSF006107 PhpActrans_proteobac, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF75138 SSF75138, 1 hit
TIGRFAMsiTIGR00651 pta, 1 hit

Sequencei

Sequence statusi: Complete.

Q9I5A5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHTFFIAPTG FGVGLTSISL GLLRALERAG LKVGFFKPIA QLHPGDLGPE
60 70 80 90 100
RSSELVARTH GLDTPKPLPL AQVERMLGDG QLDELLEEII SLYQRAAADK
110 120 130 140 150
DVVIVEGMVP TRHASYAARV NFHLAKSLDA EVILVSAPEN ETLTELTDRI
160 170 180 190 200
EIQAQLFGGP RDPKVLGVIL NKVRGEADAA NAEDGVADFA RRLTEHSPLL
210 220 230 240 250
RDDFRLIGCI PWQDELNAAR TRDIADLLSA RVINAGDYEQ RRVQKIVLCA
260 270 280 290 300
RAVPNTVQLL KPGVLVVTPG DRDDIILAAS LAAMNGVPLA GLLLCSDFPP
310 320 330 340 350
DPRIMELCRG ALQGGLPVLS VATGSYDTAT NLNRMNKEIP VDDRERAERV
360 370 380 390 400
TEFVAGHIDF EWLKQRCGTP RELRLSPPAF RYQVVQRAQK AGKRIVLPEG
410 420 430 440 450
SEPRTVQAAA ICQARGIARC VLLAKPEEVQ AVAQAQGIVL PEGLEIIDPD
460 470 480 490 500
LVRQRYVEPM VELRKGKGLN APMAEQQLED SVVLATMMLA LDEVDGLVSG
510 520 530 540 550
AIHTTASTIR PALQLIKTAP GYNLVSSVFF MLLPDQVLVY GDCAVNPDPS
560 570 580 590 600
ASDLAEIAVQ SAASAQAFGI PARVAMISYS TGDSGSGVDV DKVREATRLA
610 620 630 640 650
REQRPDLLID GPLQYDAAAI ASVGRQKAPN SPVAGQATVF IFPDLNTGNT
660 670 680 690 700
TYKAVQRSAD CVSVGPMLQG LRKPVNDLSR GALVEDIVYT IALTAIQADA

QAPA
Length:704
Mass (Da):75,697
Last modified:March 1, 2001 - v1
Checksum:iEEEF0FFDB388A88C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG04224.1
PIRiC83541
RefSeqiNP_249526.1, NC_002516.2
WP_003114221.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG04224; AAG04224; PA0835
GeneIDi882123
KEGGipae:PA0835
PATRICifig|208964.12.peg.866

Similar proteinsi

Entry informationi

Entry nameiPTA_PSEAE
AccessioniPrimary (citable) accession number: Q9I5A5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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