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Q9I5A5

- PTA_PSEAE

UniProt

Q9I5A5 - PTA_PSEAE

Protein

Phosphate acetyltransferase

Gene

pta

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Involved in acetate metabolism. In combination with LdhA and AckA, allows fermentation of pyruvate, enhancing long-term survival under anaerobic conditions.1 Publication

    Catalytic activityi

    Acetyl-CoA + phosphate = CoA + acetyl phosphate.1 Publication

    Enzyme regulationi

    Activity is increased under anaerobic growth conditions.1 Publication

    Pathwayi

    GO - Molecular functioni

    1. phosphate acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00340; UER00459.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphate acetyltransferase (EC:2.3.1.8)
    Alternative name(s):
    Phosphotransacetylase
    Gene namesi
    Name:pta
    Ordered Locus Names:PA0835
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA0835.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Disruption phenotypei

    Decreased survival under anaerobic conditions.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 704704Phosphate acetyltransferasePRO_0000405549Add
    BLAST

    Proteomic databases

    PRIDEiQ9I5A5.

    Expressioni

    Inductioni

    The ackA-pta operon is induced under oxygen-limiting conditions by the oxygen regulator Anr and DNA-binding integration host factor.1 Publication

    Interactioni

    Subunit structurei

    Homohexamer.By similarity

    Protein-protein interaction databases

    STRINGi208964.PA0835.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9I5A5.
    SMRiQ9I5A5. Positions 394-698.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni379 – 704326Phosphate acetyltransferaseAdd
    BLAST

    Domaini

    The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site By similarity.By similarity

    Sequence similaritiesi

    In the N-terminal section; belongs to the CobB/CobQ family.Curated
    In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG0280.
    KOiK13788.
    OMAiKPIAQPH.
    OrthoDBiEOG6BKJ5W.
    PhylomeDBiQ9I5A5.

    Family and domain databases

    Gene3Di3.40.1390.20. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR010766. DRTGG.
    IPR016475. P-Actrans_bac.
    IPR027417. P-loop_NTPase.
    IPR004614. P_AcTrfase.
    IPR002505. PTA_PTB.
    IPR028979. Ser_kin/Pase_Hpr_N_like.
    [Graphical view]
    PfamiPF07085. DRTGG. 1 hit.
    PF01515. PTA_PTB. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006107. PhpActrans_proteobac. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF75138. SSF75138. 1 hit.
    TIGRFAMsiTIGR00651. pta. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9I5A5-1 [UniParc]FASTAAdd to Basket

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    MHTFFIAPTG FGVGLTSISL GLLRALERAG LKVGFFKPIA QLHPGDLGPE    50
    RSSELVARTH GLDTPKPLPL AQVERMLGDG QLDELLEEII SLYQRAAADK 100
    DVVIVEGMVP TRHASYAARV NFHLAKSLDA EVILVSAPEN ETLTELTDRI 150
    EIQAQLFGGP RDPKVLGVIL NKVRGEADAA NAEDGVADFA RRLTEHSPLL 200
    RDDFRLIGCI PWQDELNAAR TRDIADLLSA RVINAGDYEQ RRVQKIVLCA 250
    RAVPNTVQLL KPGVLVVTPG DRDDIILAAS LAAMNGVPLA GLLLCSDFPP 300
    DPRIMELCRG ALQGGLPVLS VATGSYDTAT NLNRMNKEIP VDDRERAERV 350
    TEFVAGHIDF EWLKQRCGTP RELRLSPPAF RYQVVQRAQK AGKRIVLPEG 400
    SEPRTVQAAA ICQARGIARC VLLAKPEEVQ AVAQAQGIVL PEGLEIIDPD 450
    LVRQRYVEPM VELRKGKGLN APMAEQQLED SVVLATMMLA LDEVDGLVSG 500
    AIHTTASTIR PALQLIKTAP GYNLVSSVFF MLLPDQVLVY GDCAVNPDPS 550
    ASDLAEIAVQ SAASAQAFGI PARVAMISYS TGDSGSGVDV DKVREATRLA 600
    REQRPDLLID GPLQYDAAAI ASVGRQKAPN SPVAGQATVF IFPDLNTGNT 650
    TYKAVQRSAD CVSVGPMLQG LRKPVNDLSR GALVEDIVYT IALTAIQADA 700
    QAPA 704
    Length:704
    Mass (Da):75,697
    Last modified:March 1, 2001 - v1
    Checksum:iEEEF0FFDB388A88C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG04224.1.
    PIRiC83541.
    RefSeqiNP_249526.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG04224; AAG04224; PA0835.
    GeneIDi882123.
    KEGGipae:PA0835.
    PATRICi19835948. VBIPseAer58763_0866.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG04224.1 .
    PIRi C83541.
    RefSeqi NP_249526.1. NC_002516.2.

    3D structure databases

    ProteinModelPortali Q9I5A5.
    SMRi Q9I5A5. Positions 394-698.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208964.PA0835.

    Proteomic databases

    PRIDEi Q9I5A5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG04224 ; AAG04224 ; PA0835 .
    GeneIDi 882123.
    KEGGi pae:PA0835.
    PATRICi 19835948. VBIPseAer58763_0866.

    Organism-specific databases

    PseudoCAPi PA0835.

    Phylogenomic databases

    eggNOGi COG0280.
    KOi K13788.
    OMAi KPIAQPH.
    OrthoDBi EOG6BKJ5W.
    PhylomeDBi Q9I5A5.

    Enzyme and pathway databases

    UniPathwayi UPA00340 ; UER00459 .

    Family and domain databases

    Gene3Di 3.40.1390.20. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR010766. DRTGG.
    IPR016475. P-Actrans_bac.
    IPR027417. P-loop_NTPase.
    IPR004614. P_AcTrfase.
    IPR002505. PTA_PTB.
    IPR028979. Ser_kin/Pase_Hpr_N_like.
    [Graphical view ]
    Pfami PF07085. DRTGG. 1 hit.
    PF01515. PTA_PTB. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006107. PhpActrans_proteobac. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF75138. SSF75138. 1 hit.
    TIGRFAMsi TIGR00651. pta. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
    2. "Long-term anaerobic survival of the opportunistic pathogen Pseudomonas aeruginosa via pyruvate fermentation."
      Eschbach M., Schreiber K., Trunk K., Buer J., Jahn D., Schobert M.
      J. Bacteriol. 186:4596-4604(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, INDUCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiPTA_PSEAE
    AccessioniPrimary (citable) accession number: Q9I5A5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 8, 2011
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3