Q9I5A4 (ACKA_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetate kinase
EC=2.7.2.1

Alternative name(s):
Acetokinase

Gene names

Name:	ackA
Ordered Locus Names:	PA0836

Organism

Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

Taxonomic identifier

208964 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity HAMAP MF_00020.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Acetate kinase HAMAP MF_00020		PRO_0000107602

Sequences

	Sequence		Length	Mass (Da)
	Q9I5A4 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: C2ADAF4EBC7C1CB3	FASTA	394	42,421
	10 20 30 40 50 60 MPSRNILVIN CGSSSIKFAL VNEAHSLFPL HGLAERLGSR DAVLRWKRGG DSDSLMIPNA 70 80 90 100 110 120 DHRAALAQLL PMVQNAAGGK LHGIGHRVVH GGELFTHATR IDDRVVEAIR ATAPLAPLHN 130 140 150 160 170 180 PANLQGIEAA MTLFPKLPHV AVFDTAFHQS LPEHAYRYAL PEALYREHGV RRYGFHGTSH 190 200 210 220 230 240 RYVSHRAAEM AGLAVGDSSW LSAHLGNGSS TCAIVNGQSL DTSMGLTPLE GLVMGTRSGD 250 260 270 280 290 300 VDPNLHSHLA RTLGWSLERI DSMLNNESGL LGLSDLSNDM RTLEQEREQG HPGAALAIEV 310 320 330 340 350 360 FCYRLAKSLA AMSCALPQLD GVIFTGGIGE NSPLVRAKTA AHLRLFDLRL DQEANARCVR 370 380 390 GVAGPIQAAG HPRVLVIPTN EERQIALDTL ALLD

References

[1]

"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen." Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. , Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V. Nature 406:959-964(2000) [PubMed: 10984043] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004091 Genomic DNA. Translation: AAG04225.1.
PIR	D83541.
RefSeq	NP_249527.1. NC_002516.2.
3D structure databases
ProteinModelPortal	Q9I5A4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	877790.
GenomeReviews	Gene locus PA0836 in contig AE004091_GR.
KEGG	pae:PA0836.
PATRIC	19835950. VBIPseAer58763_0867.
Organism-specific databases
PseudoCAP	PA0836.
Phylogenomic databases
HOGENOM	HBG285863.
OMA	AQSIFKD.
ProtClustDB	PRK00180.
Enzyme and pathway databases
BioCyc	PAER208964:PA0836-MONOMER.
Family and domain databases
HAMAP	MF_00020. Acetate_kinase. [Tree]
InterPro	IPR004372. Ac/Proprionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS. [Graphical view]
KO	K00925.
PANTHER	PTHR21060. Acetate_kin. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. AckA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_PSEAE

Accession

Primary (citable) accession number: Q9I5A4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2003
Last sequence update:	March 1, 2001
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program