Q9I576 (HPPD_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
4-hydroxyphenylpyruvate dioxygenase
Short name=4HPPD
Short name=HPD
Short name=HPPDase
EC=1.13.11.27

Gene names

Name:	hpd
Ordered Locus Names:	PA0865

Organism

Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) [Reference proteome] [HAMAP]

Taxonomic identifier

208964 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › Pseudomonas aeruginosa group › Pseudomonas aeruginosa

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.
Cofactor	Binds 1 iron ion per subunit By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the 4HPPD family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway tyrosine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	4-hydroxyphenylpyruvate dioxygenase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	4-hydroxyphenylpyruvate dioxygenase		PRO_0000287741
Sites
	Metal binding	168	1	Iron By similarity
	Metal binding	246	1	Iron By similarity
	Metal binding	325	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9I576 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 016A5C233DE0E2F9	FASTA	357	39,913
	10 20 30 40 50 60 MNAVAKIEQH NPIGTDGFEF VEFTAPDAKG IEQLRQLFNM MGFTETAKHR SKEVFLFQQN 70 80 90 100 110 120 DINIVLNGSP TGHVHEFALK HGPSACAMAF RVKNASQAAA YAESQGAKLV GSHANFGELN 130 140 150 160 170 180 IPSLEGIGGS LLYLVDRYGD RSIYDVDFEF IEGRSANDNS VGLTYIDHLT HNVKRGQMDV 190 200 210 220 230 240 WSGFYERIAN FREIRYFDIE GKLTGLFSRA MTAPCGKIRI PINESADDTS QIEEFIREYH 250 260 270 280 290 300 GEGIQHIALT TDDIYATVRK LRDNGVKFMS TPDTYYEKVD TRVAGHGEPL EQLRELNLLI 310 320 330 340 350 DGAPGDDGIL LQIFTDTVIG PIFFEIIQRK GNQGFGEGNF KALFESIEED QIRRGVI

References

[1]

"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen." Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. , Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V. Nature 406:959-964(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004091 Genomic DNA. Translation: AAG04254.1.
PIR	F83537.
RefSeq	NP_249556.1. NC_002516.2.
3D structure databases
HSSP	HSSP built from PDB template 1SQD based on UniProtKB P93836.
ProteinModelPortal	Q9I576.
SMR	Q9I576. Positions 11-357.
ModBase	Search...
Protein-protein interaction databases
STRING	208964.PA0865.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	882225.
KEGG	pae:PA0865.
PATRIC	19836014. VBIPseAer58763_0899.
Organism-specific databases
PseudoCAP	PA0865.
Phylogenomic databases
eggNOG	COG3185.
HOGENOM	HOG000188688.
KO	K00457.
OMA	PDTYYEK.
ProtClustDB	CLSK866176.
Enzyme and pathway databases
UniPathway	UPA00139; UER00362.
Family and domain databases
InterPro	IPR005956. 4OHPhenylPyrv_dOase. IPR004360. Glyas_Fos-R_dOase_dom. [Graphical view]
PANTHER	PTHR11959. PTHR11959. 1 hit.
Pfam	PF00903. Glyoxalase. 1 hit. [Graphical view]
PIRSF	PIRSF009283. HPP_dOase. 1 hit.
TIGRFAMs	TIGR01263. 4HPPD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HPPD_PSEAE

Accession

Primary (citable) accession number: Q9I576

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program