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Reviewed, UniProtKB/Swiss-Prot Q9I576 (HPPD_PSEAE)

Last modified July 22, 2008. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    4-hydroxyphenylpyruvate dioxygenase
      Short name(s)=HPPDase, 4HPPD, HPD
    EC=1.13.11.27
Gene names
Name: hpd
Ordered Locus Names: PA0865
OrganismPseudomonas aeruginosa [Complete proteome] [HAMAP]
Taxonomic identifier287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

4-hydroxyphenylpyruvate + O(2) = homogentisate + CO(2).

Cofactor

Binds 1 iron ion per subunit By similarity.

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 3/6.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the 4HPPD family.

Ontologies

Keywords

   Biological processPhenylalanine catabolism
Tyrosine catabolism
   LigandIron
Metal-binding
   Molecular functionDioxygenase
Oxidoreductase
   Technical termComplete proteome

Gene Ontology (GO)

None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 3573574-hydroxyphenylpyruvate dioxygenase

Sites

Metal binding1681Iron By similarity
Metal binding2461Iron By similarity
Metal binding3251Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9I576-1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 016A5C233DE0E2F9

FASTA35739,913
        10         20         30         40         50         60 
MNAVAKIEQH NPIGTDGFEF VEFTAPDAKG IEQLRQLFNM MGFTETAKHR SKEVFLFQQN 

        70         80         90        100        110        120 
DINIVLNGSP TGHVHEFALK HGPSACAMAF RVKNASQAAA YAESQGAKLV GSHANFGELN 

       130        140        150        160        170        180 
IPSLEGIGGS LLYLVDRYGD RSIYDVDFEF IEGRSANDNS VGLTYIDHLT HNVKRGQMDV 

       190        200        210        220        230        240 
WSGFYERIAN FREIRYFDIE GKLTGLFSRA MTAPCGKIRI PINESADDTS QIEEFIREYH 

       250        260        270        280        290        300 
GEGIQHIALT TDDIYATVRK LRDNGVKFMS TPDTYYEKVD TRVAGHGEPL EQLRELNLLI 

       310        320        330        340        350 
DGAPGDDGIL LQIFTDTVIG PIFFEIIQRK GNQGFGEGNF KALFESIEED QIRRGVI 

« Hide

Cross-references

Sequence databases

AE004091 Genomic DNA. Translation: AAG04254.1.
PIRF83537.
RefSeqNP_249556.1.

3D structure databases

HSSPHSSP built from PDB template 1CJX based on UniProtKB P80064.
ModBaseSearch...

Genome annotation databases

GeneID882225.
GenomeReviewsGene locus PA0865 in contig AE004091_GR.
KEGGpae:PA0865.

Organism-specific databases

PseudoCAPPA0865.
CMRSearch...

Phylogenomic databases

HOGENOMQ9I576.

Enzyme and pathway databases

BioCycPAER208964:PA0865-MON.

Family and domain databases

InterProIPR005956. 4OHPhenylPyrv_dOase.
IPR004360. Glyas_bleo-R_dOase.
[Graphical view]
PANTHERPTHR11959. HPP_dOase. 1 hit.
PfamPF00903. Glyoxalase. 1 hit.
[Graphical view]
PIRSFPIRSF009283. HPP_dOase. 1 hit.
TIGRFAMsTIGR01263. 4HPPD. 1 hit.
ProDomQ9I576.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

Entry information

Entry nameHPPD_PSEAE
AccessionPrimary (citable) accession number: Q9I576
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: July 22, 2008
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Recent format changes

Overview of recent format changes

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents