Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

4-hydroxyphenylpyruvate dioxygenase

Gene

hpd

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.

Cofactori

Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity

Pathwayi: L-phenylalanine degradation

This protein is involved in step 3 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Phenylalanine-4-hydroxylase (phhA)
  2. no protein annotated in this organism
  3. 4-hydroxyphenylpyruvate dioxygenase (hpd)
  4. Homogentisate 1,2-dioxygenase (hmgA)
  5. Maleylacetoacetate isomerase (maiA)
  6. no protein annotated in this organism
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi168IronBy similarity1
Metal bindingi246IronBy similarity1
Metal bindingi325IronBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processPhenylalanine catabolism, Tyrosine catabolism
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-880-MONOMER
UniPathwayiUPA00139; UER00362

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxyphenylpyruvate dioxygenase (EC:1.13.11.27)
Short name:
4HPPD
Short name:
HPD
Short name:
HPPDase
Gene namesi
Name:hpd
Ordered Locus Names:PA0865
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA0865

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002877411 – 3574-hydroxyphenylpyruvate dioxygenaseAdd BLAST357

Proteomic databases

PaxDbiQ9I576
PRIDEiQ9I576

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi208964.PA0865

Structurei

3D structure databases

ProteinModelPortaliQ9I576
SMRiQ9I576
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 137VOC 1PROSITE-ProRule annotationAdd BLAST121
Domaini165 – 316VOC 2PROSITE-ProRule annotationAdd BLAST152

Sequence similaritiesi

Belongs to the 4HPPD family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105E6K Bacteria
COG3185 LUCA
HOGENOMiHOG000188688
InParanoidiQ9I576
KOiK00457
OMAiVWSGFYE
PhylomeDBiQ9I576

Family and domain databases

Gene3Di3.10.180.10, 2 hits
InterProiView protein in InterPro
IPR005956 4OHPhenylPyrv_dOase
IPR029068 Glyas_Bleomycin-R_OHBP_Dase
IPR004360 Glyas_Fos-R_dOase_dom
IPR037523 VOC
PANTHERiPTHR11959 PTHR11959, 1 hit
PfamiView protein in Pfam
PF00903 Glyoxalase, 1 hit
PIRSFiPIRSF009283 HPP_dOase, 1 hit
SUPFAMiSSF54593 SSF54593, 1 hit
TIGRFAMsiTIGR01263 4HPPD, 1 hit
PROSITEiView protein in PROSITE
PS51819 VOC, 2 hits

Sequencei

Sequence statusi: Complete.

Q9I576-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAVAKIEQH NPIGTDGFEF VEFTAPDAKG IEQLRQLFNM MGFTETAKHR
60 70 80 90 100
SKEVFLFQQN DINIVLNGSP TGHVHEFALK HGPSACAMAF RVKNASQAAA
110 120 130 140 150
YAESQGAKLV GSHANFGELN IPSLEGIGGS LLYLVDRYGD RSIYDVDFEF
160 170 180 190 200
IEGRSANDNS VGLTYIDHLT HNVKRGQMDV WSGFYERIAN FREIRYFDIE
210 220 230 240 250
GKLTGLFSRA MTAPCGKIRI PINESADDTS QIEEFIREYH GEGIQHIALT
260 270 280 290 300
TDDIYATVRK LRDNGVKFMS TPDTYYEKVD TRVAGHGEPL EQLRELNLLI
310 320 330 340 350
DGAPGDDGIL LQIFTDTVIG PIFFEIIQRK GNQGFGEGNF KALFESIEED

QIRRGVI
Length:357
Mass (Da):39,913
Last modified:March 1, 2001 - v1
Checksum:i016A5C233DE0E2F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG04254.1
PIRiF83537
RefSeqiNP_249556.1, NC_002516.2
WP_003106569.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG04254; AAG04254; PA0865
GeneIDi882225
KEGGipae:PA0865
PATRICifig|208964.12.peg.899

Similar proteinsi

Entry informationi

Entry nameiHPPD_PSEAE
AccessioniPrimary (citable) accession number: Q9I576
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health