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Q9I576

- HPPD_PSEAE

UniProt

Q9I576 - HPPD_PSEAE

Protein

4-hydroxyphenylpyruvate dioxygenase

Gene

hpd

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.

    Cofactori

    Binds 1 iron ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi168 – 1681IronBy similarity
    Metal bindingi246 – 2461IronBy similarity
    Metal bindingi325 – 3251IronBy similarity

    GO - Molecular functioni

    1. 4-hydroxyphenylpyruvate dioxygenase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. L-phenylalanine catabolic process Source: UniProtKB-UniPathway
    2. tyrosine catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Phenylalanine catabolism, Tyrosine catabolism

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00139; UER00362.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxyphenylpyruvate dioxygenase (EC:1.13.11.27)
    Short name:
    4HPPD
    Short name:
    HPD
    Short name:
    HPPDase
    Gene namesi
    Name:hpd
    Ordered Locus Names:PA0865
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA0865.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3573574-hydroxyphenylpyruvate dioxygenasePRO_0000287741Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi208964.PA0865.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9I576.
    SMRiQ9I576. Positions 11-357.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the 4HPPD family.Curated

    Phylogenomic databases

    eggNOGiCOG3185.
    HOGENOMiHOG000188688.
    KOiK00457.
    OMAiDKWWDFY.
    OrthoDBiEOG68SVVG.
    PhylomeDBiQ9I576.

    Family and domain databases

    Gene3Di3.10.180.10. 2 hits.
    InterProiIPR005956. 4OHPhenylPyrv_dOase.
    IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
    IPR004360. Glyas_Fos-R_dOase_dom.
    [Graphical view]
    PANTHERiPTHR11959. PTHR11959. 1 hit.
    PfamiPF00903. Glyoxalase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009283. HPP_dOase. 1 hit.
    SUPFAMiSSF54593. SSF54593. 1 hit.
    TIGRFAMsiTIGR01263. 4HPPD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9I576-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNAVAKIEQH NPIGTDGFEF VEFTAPDAKG IEQLRQLFNM MGFTETAKHR    50
    SKEVFLFQQN DINIVLNGSP TGHVHEFALK HGPSACAMAF RVKNASQAAA 100
    YAESQGAKLV GSHANFGELN IPSLEGIGGS LLYLVDRYGD RSIYDVDFEF 150
    IEGRSANDNS VGLTYIDHLT HNVKRGQMDV WSGFYERIAN FREIRYFDIE 200
    GKLTGLFSRA MTAPCGKIRI PINESADDTS QIEEFIREYH GEGIQHIALT 250
    TDDIYATVRK LRDNGVKFMS TPDTYYEKVD TRVAGHGEPL EQLRELNLLI 300
    DGAPGDDGIL LQIFTDTVIG PIFFEIIQRK GNQGFGEGNF KALFESIEED 350
    QIRRGVI 357
    Length:357
    Mass (Da):39,913
    Last modified:March 1, 2001 - v1
    Checksum:i016A5C233DE0E2F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG04254.1.
    PIRiF83537.
    RefSeqiNP_249556.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG04254; AAG04254; PA0865.
    GeneIDi882225.
    KEGGipae:PA0865.
    PATRICi19836014. VBIPseAer58763_0899.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG04254.1 .
    PIRi F83537.
    RefSeqi NP_249556.1. NC_002516.2.

    3D structure databases

    ProteinModelPortali Q9I576.
    SMRi Q9I576. Positions 11-357.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208964.PA0865.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG04254 ; AAG04254 ; PA0865 .
    GeneIDi 882225.
    KEGGi pae:PA0865.
    PATRICi 19836014. VBIPseAer58763_0899.

    Organism-specific databases

    PseudoCAPi PA0865.

    Phylogenomic databases

    eggNOGi COG3185.
    HOGENOMi HOG000188688.
    KOi K00457.
    OMAi DKWWDFY.
    OrthoDBi EOG68SVVG.
    PhylomeDBi Q9I576.

    Enzyme and pathway databases

    UniPathwayi UPA00139 ; UER00362 .

    Family and domain databases

    Gene3Di 3.10.180.10. 2 hits.
    InterProi IPR005956. 4OHPhenylPyrv_dOase.
    IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
    IPR004360. Glyas_Fos-R_dOase_dom.
    [Graphical view ]
    PANTHERi PTHR11959. PTHR11959. 1 hit.
    Pfami PF00903. Glyoxalase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009283. HPP_dOase. 1 hit.
    SUPFAMi SSF54593. SSF54593. 1 hit.
    TIGRFAMsi TIGR01263. 4HPPD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

    Entry informationi

    Entry nameiHPPD_PSEAE
    AccessioniPrimary (citable) accession number: Q9I576
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3