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Protein

4-hydroxyphenylpyruvate dioxygenase

Gene

hpd

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.

Cofactori

Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi168 – 1681IronBy similarity
Metal bindingi246 – 2461IronBy similarity
Metal bindingi325 – 3251IronBy similarity

GO - Molecular functioni

  1. 4-hydroxyphenylpyruvate dioxygenase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. L-phenylalanine catabolic process Source: UniProtKB-UniPathway
  2. tyrosine catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00139; UER00362.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxyphenylpyruvate dioxygenase (EC:1.13.11.27)
Short name:
4HPPD
Short name:
HPD
Short name:
HPPDase
Gene namesi
Name:hpd
Ordered Locus Names:PA0865
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA0865.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3573574-hydroxyphenylpyruvate dioxygenasePRO_0000287741Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi208964.PA0865.

Structurei

3D structure databases

ProteinModelPortaliQ9I576.
SMRiQ9I576. Positions 11-357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 4HPPD family.Curated

Phylogenomic databases

eggNOGiCOG3185.
HOGENOMiHOG000188688.
InParanoidiQ9I576.
KOiK00457.
OMAiIANFREI.
OrthoDBiEOG68SVVG.
PhylomeDBiQ9I576.

Family and domain databases

Gene3Di3.10.180.10. 2 hits.
InterProiIPR005956. 4OHPhenylPyrv_dOase.
IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR004360. Glyas_Fos-R_dOase_dom.
[Graphical view]
PANTHERiPTHR11959. PTHR11959. 1 hit.
PfamiPF00903. Glyoxalase. 1 hit.
[Graphical view]
PIRSFiPIRSF009283. HPP_dOase. 1 hit.
SUPFAMiSSF54593. SSF54593. 1 hit.
TIGRFAMsiTIGR01263. 4HPPD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9I576-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAVAKIEQH NPIGTDGFEF VEFTAPDAKG IEQLRQLFNM MGFTETAKHR
60 70 80 90 100
SKEVFLFQQN DINIVLNGSP TGHVHEFALK HGPSACAMAF RVKNASQAAA
110 120 130 140 150
YAESQGAKLV GSHANFGELN IPSLEGIGGS LLYLVDRYGD RSIYDVDFEF
160 170 180 190 200
IEGRSANDNS VGLTYIDHLT HNVKRGQMDV WSGFYERIAN FREIRYFDIE
210 220 230 240 250
GKLTGLFSRA MTAPCGKIRI PINESADDTS QIEEFIREYH GEGIQHIALT
260 270 280 290 300
TDDIYATVRK LRDNGVKFMS TPDTYYEKVD TRVAGHGEPL EQLRELNLLI
310 320 330 340 350
DGAPGDDGIL LQIFTDTVIG PIFFEIIQRK GNQGFGEGNF KALFESIEED

QIRRGVI
Length:357
Mass (Da):39,913
Last modified:March 1, 2001 - v1
Checksum:i016A5C233DE0E2F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG04254.1.
PIRiF83537.
RefSeqiNP_249556.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG04254; AAG04254; PA0865.
GeneIDi882225.
KEGGipae:PA0865.
PATRICi19836014. VBIPseAer58763_0899.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG04254.1.
PIRiF83537.
RefSeqiNP_249556.1. NC_002516.2.

3D structure databases

ProteinModelPortaliQ9I576.
SMRiQ9I576. Positions 11-357.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA0865.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG04254; AAG04254; PA0865.
GeneIDi882225.
KEGGipae:PA0865.
PATRICi19836014. VBIPseAer58763_0899.

Organism-specific databases

PseudoCAPiPA0865.

Phylogenomic databases

eggNOGiCOG3185.
HOGENOMiHOG000188688.
InParanoidiQ9I576.
KOiK00457.
OMAiIANFREI.
OrthoDBiEOG68SVVG.
PhylomeDBiQ9I576.

Enzyme and pathway databases

UniPathwayiUPA00139; UER00362.

Family and domain databases

Gene3Di3.10.180.10. 2 hits.
InterProiIPR005956. 4OHPhenylPyrv_dOase.
IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR004360. Glyas_Fos-R_dOase_dom.
[Graphical view]
PANTHERiPTHR11959. PTHR11959. 1 hit.
PfamiPF00903. Glyoxalase. 1 hit.
[Graphical view]
PIRSFiPIRSF009283. HPP_dOase. 1 hit.
SUPFAMiSSF54593. SSF54593. 1 hit.
TIGRFAMsiTIGR01263. 4HPPD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiHPPD_PSEAE
AccessioniPrimary (citable) accession number: Q9I576
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: January 7, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.