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Q9I472

- COBO_PSEAE

UniProt

Q9I472 - COBO_PSEAE

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Protein

Cob(I)yrinic acid a,c-diamide adenosyltransferase

Gene
cobO, PA1272
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids By similarity.

Catalytic activityi

ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide.
ATP + cobinamide = triphosphate + adenosylcobinamide.

Cofactori

Manganese By similarity.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi41 – 477ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cob(I)yrinic acid a,c-diamide adenosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. cobalamin biosynthetic process Source: UniProtKB-UniPathway
  2. porphyrin-containing compound biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cobalamin biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

ATP-binding, Manganese, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00148; UER00233.

Names & Taxonomyi

Protein namesi
Recommended name:
Cob(I)yrinic acid a,c-diamide adenosyltransferase (EC:2.5.1.17)
Alternative name(s):
Cob(I)alamin adenosyltransferase
Corrinoid adenosyltransferase
Gene namesi
Name:cobO
Ordered Locus Names:PA1272
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA1272.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Cob(I)yrinic acid a,c-diamide adenosyltransferasePRO_0000287788Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi208964.PA1272.

Structurei

3D structure databases

ProteinModelPortaliQ9I472.
SMRiQ9I472. Positions 33-203.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2109.
HOGENOMiHOG000260311.
KOiK00798.
OMAiNISWHSL.
OrthoDBiEOG6GN76J.
PhylomeDBiQ9I472.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003724. AdoCbl_synth_CblAdoTrfase_CobA.
IPR025826. Co_AT_N_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF12557. Co_AT_N. 1 hit.
PF02572. CobA_CobO_BtuR. 1 hit.
[Graphical view]
PIRSFiPIRSF015617. Adensltrnsf_CobA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00708. cobA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9I472-1 [UniParc]FASTAAdd to Basket

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MNESPEKDQR HRERMERKKA VVDEKIAQAR DERGVLLVHS GNGKGKSSSA    50
FGMVARALGH GMKVGVVQFI KGAASTGEEA FFRRFPEEVS YHVMGEGFTW 100
ETQDRQRDIA KAEAAWKVAA QLLADPDVGL VVLDELNIAL KHGYLELDRV 150
LADIQARPAM QHVVVTGRGA QPGMIEAADT VTEMSLVKHA FKAGIKAQKG 200
VEF 203
Length:203
Mass (Da):22,292
Last modified:March 1, 2001 - v1
Checksum:i2176356693732743
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG04661.1.
PIRiF83485.
RefSeqiNP_249963.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG04661; AAG04661; PA1272.
GeneIDi881408.
KEGGipae:PA1272.
PATRICi19836872. VBIPseAer58763_1322.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG04661.1 .
PIRi F83485.
RefSeqi NP_249963.1. NC_002516.2.

3D structure databases

ProteinModelPortali Q9I472.
SMRi Q9I472. Positions 33-203.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA1272.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG04661 ; AAG04661 ; PA1272 .
GeneIDi 881408.
KEGGi pae:PA1272.
PATRICi 19836872. VBIPseAer58763_1322.

Organism-specific databases

PseudoCAPi PA1272.

Phylogenomic databases

eggNOGi COG2109.
HOGENOMi HOG000260311.
KOi K00798.
OMAi NISWHSL.
OrthoDBi EOG6GN76J.
PhylomeDBi Q9I472.

Enzyme and pathway databases

UniPathwayi UPA00148 ; UER00233 .

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003724. AdoCbl_synth_CblAdoTrfase_CobA.
IPR025826. Co_AT_N_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF12557. Co_AT_N. 1 hit.
PF02572. CobA_CobO_BtuR. 1 hit.
[Graphical view ]
PIRSFi PIRSF015617. Adensltrnsf_CobA. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00708. cobA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiCOBO_PSEAE
AccessioniPrimary (citable) accession number: Q9I472
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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