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Protein

Cob(I)yrinic acid a,c-diamide adenosyltransferase

Gene

cobO

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids (By similarity).By similarity

Catalytic activityi

ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide.
ATP + cobinamide = triphosphate + adenosylcobinamide.

Cofactori

Mn2+By similarity

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes adenosylcobalamin from cob(II)yrinate a,c-diamide.
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Cob(I)yrinic acid a,c-diamide adenosyltransferase (cobO)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Bifunctional adenosylcobalamin biosynthesis protein CobP (cobP)
  6. Bifunctional adenosylcobalamin biosynthesis protein CobP (cobP)
  7. Adenosylcobinamide-GDP ribazoletransferase (cobS)
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes adenosylcobalamin from cob(II)yrinate a,c-diamide, the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi41 – 47ATPBy similarity7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCobalamin biosynthesis, Porphyrin biosynthesis
LigandATP-binding, Manganese, Nucleotide-binding

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-1297-MONOMER
UniPathwayiUPA00148; UER00233

Names & Taxonomyi

Protein namesi
Recommended name:
Cob(I)yrinic acid a,c-diamide adenosyltransferase (EC:2.5.1.17)
Alternative name(s):
Cob(I)alamin adenosyltransferase
Corrinoid adenosyltransferase
Gene namesi
Name:cobO
Ordered Locus Names:PA1272
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA1272

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002877881 – 203Cob(I)yrinic acid a,c-diamide adenosyltransferaseAdd BLAST203

Proteomic databases

PaxDbiQ9I472

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi208964.PA1272

Structurei

3D structure databases

ProteinModelPortaliQ9I472
SMRiQ9I472
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG41068B1 Bacteria
COG2109 LUCA
HOGENOMiHOG000260311
InParanoidiQ9I472
KOiK19221
OMAiHAFKAGV
PhylomeDBiQ9I472

Family and domain databases

CDDicd00561 CobA_CobO_BtuR, 1 hit
InterProiView protein in InterPro
IPR003724 CblAdoTrfase_CobA
IPR025826 Co_AT_N_dom
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF12557 Co_AT_N, 1 hit
PF02572 CobA_CobO_BtuR, 1 hit
PIRSFiPIRSF015617 Adensltrnsf_CobA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00708 cobA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9I472-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNESPEKDQR HRERMERKKA VVDEKIAQAR DERGVLLVHS GNGKGKSSSA
60 70 80 90 100
FGMVARALGH GMKVGVVQFI KGAASTGEEA FFRRFPEEVS YHVMGEGFTW
110 120 130 140 150
ETQDRQRDIA KAEAAWKVAA QLLADPDVGL VVLDELNIAL KHGYLELDRV
160 170 180 190 200
LADIQARPAM QHVVVTGRGA QPGMIEAADT VTEMSLVKHA FKAGIKAQKG

VEF
Length:203
Mass (Da):22,292
Last modified:March 1, 2001 - v1
Checksum:i2176356693732743
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG04661.1
PIRiF83485
RefSeqiNP_249963.1, NC_002516.2
WP_003086769.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG04661; AAG04661; PA1272
GeneIDi881408
KEGGipae:PA1272
PATRICifig|208964.12.peg.1322

Similar proteinsi

Entry informationi

Entry nameiCOBO_PSEAE
AccessioniPrimary (citable) accession number: Q9I472
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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