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Q9I472

- COBO_PSEAE

UniProt

Q9I472 - COBO_PSEAE

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Protein

Cob(I)yrinic acid a,c-diamide adenosyltransferase

Gene

cobO

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids (By similarity).By similarity

Catalytic activityi

ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide.
ATP + cobinamide = triphosphate + adenosylcobinamide.

Cofactori

Mn2+By similarity

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi41 – 477ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cob(I)yrinic acid a,c-diamide adenosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. cobalamin biosynthetic process Source: UniProtKB-UniPathway
  2. porphyrin-containing compound biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cobalamin biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

ATP-binding, Manganese, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00148; UER00233.

Names & Taxonomyi

Protein namesi
Recommended name:
Cob(I)yrinic acid a,c-diamide adenosyltransferase (EC:2.5.1.17)
Alternative name(s):
Cob(I)alamin adenosyltransferase
Corrinoid adenosyltransferase
Gene namesi
Name:cobO
Ordered Locus Names:PA1272
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA1272.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Cob(I)yrinic acid a,c-diamide adenosyltransferasePRO_0000287788Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi208964.PA1272.

Structurei

3D structure databases

ProteinModelPortaliQ9I472.
SMRiQ9I472. Positions 33-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2109.
HOGENOMiHOG000260311.
InParanoidiQ9I472.
KOiK00798.
OMAiNISWHSL.
OrthoDBiEOG6GN76J.
PhylomeDBiQ9I472.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003724. AdoCbl_synth_CblAdoTrfase_CobA.
IPR025826. Co_AT_N_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF12557. Co_AT_N. 1 hit.
PF02572. CobA_CobO_BtuR. 1 hit.
[Graphical view]
PIRSFiPIRSF015617. Adensltrnsf_CobA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00708. cobA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9I472-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MNESPEKDQR HRERMERKKA VVDEKIAQAR DERGVLLVHS GNGKGKSSSA
60 70 80 90 100
FGMVARALGH GMKVGVVQFI KGAASTGEEA FFRRFPEEVS YHVMGEGFTW
110 120 130 140 150
ETQDRQRDIA KAEAAWKVAA QLLADPDVGL VVLDELNIAL KHGYLELDRV
160 170 180 190 200
LADIQARPAM QHVVVTGRGA QPGMIEAADT VTEMSLVKHA FKAGIKAQKG

VEF
Length:203
Mass (Da):22,292
Last modified:March 1, 2001 - v1
Checksum:i2176356693732743
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG04661.1.
PIRiF83485.
RefSeqiNP_249963.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG04661; AAG04661; PA1272.
GeneIDi881408.
KEGGipae:PA1272.
PATRICi19836872. VBIPseAer58763_1322.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG04661.1 .
PIRi F83485.
RefSeqi NP_249963.1. NC_002516.2.

3D structure databases

ProteinModelPortali Q9I472.
SMRi Q9I472. Positions 33-203.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA1272.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG04661 ; AAG04661 ; PA1272 .
GeneIDi 881408.
KEGGi pae:PA1272.
PATRICi 19836872. VBIPseAer58763_1322.

Organism-specific databases

PseudoCAPi PA1272.

Phylogenomic databases

eggNOGi COG2109.
HOGENOMi HOG000260311.
InParanoidi Q9I472.
KOi K00798.
OMAi NISWHSL.
OrthoDBi EOG6GN76J.
PhylomeDBi Q9I472.

Enzyme and pathway databases

UniPathwayi UPA00148 ; UER00233 .

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003724. AdoCbl_synth_CblAdoTrfase_CobA.
IPR025826. Co_AT_N_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF12557. Co_AT_N. 1 hit.
PF02572. CobA_CobO_BtuR. 1 hit.
[Graphical view ]
PIRSFi PIRSF015617. Adensltrnsf_CobA. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00708. cobA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiCOBO_PSEAE
AccessioniPrimary (citable) accession number: Q9I472
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: November 26, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3