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Protein

Cob(I)yrinic acid a,c-diamide adenosyltransferase

Gene

cobO

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids (By similarity).By similarity

Catalytic activityi

ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide.
ATP + cobinamide = triphosphate + adenosylcobinamide.

Cofactori

Mn2+By similarity

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes adenosylcobalamin from cob(II)yrinate a,c-diamide.
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Cob(I)yrinic acid a,c-diamide adenosyltransferase (cobO)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Bifunctional adenosylcobalamin biosynthesis protein CobP (cobP)
  6. Bifunctional adenosylcobalamin biosynthesis protein CobP (cobP)
  7. Adenosylcobinamide-GDP ribazoletransferase (cobS)
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes adenosylcobalamin from cob(II)yrinate a,c-diamide, the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi41 – 47ATPBy similarity7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCobalamin biosynthesis, Porphyrin biosynthesis
LigandATP-binding, Manganese, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00148; UER00233.

Names & Taxonomyi

Protein namesi
Recommended name:
Cob(I)yrinic acid a,c-diamide adenosyltransferase (EC:2.5.1.17)
Alternative name(s):
Cob(I)alamin adenosyltransferase
Corrinoid adenosyltransferase
Gene namesi
Name:cobO
Ordered Locus Names:PA1272
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA1272.

Subcellular locationi

Q9I472:

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002877881 – 203Cob(I)yrinic acid a,c-diamide adenosyltransferaseAdd BLAST203

Proteomic databases

PaxDbiQ9I472.
PRIDEiQ9I472.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi208964.PA1272.

Structurei

3D structure databases

ProteinModelPortaliQ9I472.
SMRiQ9I472.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG41068B1. Bacteria.
COG2109. LUCA.
HOGENOMiHOG000260311.
InParanoidiQ9I472.
KOiK19221.
OMAiHAFKAGV.
PhylomeDBiQ9I472.

Family and domain databases

CDDicd00561. CobA_CobO_BtuR. 1 hit.
InterProiView protein in InterPro
IPR003724. CblAdoTrfase_CobA.
IPR025826. Co_AT_N_dom.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF12557. Co_AT_N. 1 hit.
PF02572. CobA_CobO_BtuR. 1 hit.
PIRSFiPIRSF015617. Adensltrnsf_CobA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00708. cobA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9I472-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNESPEKDQR HRERMERKKA VVDEKIAQAR DERGVLLVHS GNGKGKSSSA
60 70 80 90 100
FGMVARALGH GMKVGVVQFI KGAASTGEEA FFRRFPEEVS YHVMGEGFTW
110 120 130 140 150
ETQDRQRDIA KAEAAWKVAA QLLADPDVGL VVLDELNIAL KHGYLELDRV
160 170 180 190 200
LADIQARPAM QHVVVTGRGA QPGMIEAADT VTEMSLVKHA FKAGIKAQKG

VEF
Length:203
Mass (Da):22,292
Last modified:March 1, 2001 - v1
Checksum:i2176356693732743
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG04661.1.
PIRiF83485.
RefSeqiNP_249963.1. NC_002516.2.
WP_003086769.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG04661; AAG04661; PA1272.
GeneIDi881408.
KEGGipae:PA1272.
PATRICifig|208964.12.peg.1322.

Similar proteinsi

Entry informationi

Entry nameiCOBO_PSEAE
AccessioniPrimary (citable) accession number: Q9I472
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: October 25, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families