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Q9I472

- COBO_PSEAE

UniProt

Q9I472 - COBO_PSEAE

Protein

Cob(I)yrinic acid a,c-diamide adenosyltransferase

Gene

cobO

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids By similarity.By similarity

    Catalytic activityi

    ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide.
    ATP + cobinamide = triphosphate + adenosylcobinamide.

    Cofactori

    Manganese.By similarity

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi41 – 477ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cob(I)yrinic acid a,c-diamide adenosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cobalamin biosynthetic process Source: UniProtKB-UniPathway
    2. porphyrin-containing compound biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Cobalamin biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    ATP-binding, Manganese, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00148; UER00233.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cob(I)yrinic acid a,c-diamide adenosyltransferase (EC:2.5.1.17)
    Alternative name(s):
    Cob(I)alamin adenosyltransferase
    Corrinoid adenosyltransferase
    Gene namesi
    Name:cobO
    Ordered Locus Names:PA1272
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA1272.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 203203Cob(I)yrinic acid a,c-diamide adenosyltransferasePRO_0000287788Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi208964.PA1272.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9I472.
    SMRiQ9I472. Positions 33-203.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2109.
    HOGENOMiHOG000260311.
    KOiK00798.
    OMAiNISWHSL.
    OrthoDBiEOG6GN76J.
    PhylomeDBiQ9I472.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003724. AdoCbl_synth_CblAdoTrfase_CobA.
    IPR025826. Co_AT_N_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF12557. Co_AT_N. 1 hit.
    PF02572. CobA_CobO_BtuR. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015617. Adensltrnsf_CobA. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00708. cobA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9I472-1 [UniParc]FASTAAdd to Basket

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    MNESPEKDQR HRERMERKKA VVDEKIAQAR DERGVLLVHS GNGKGKSSSA    50
    FGMVARALGH GMKVGVVQFI KGAASTGEEA FFRRFPEEVS YHVMGEGFTW 100
    ETQDRQRDIA KAEAAWKVAA QLLADPDVGL VVLDELNIAL KHGYLELDRV 150
    LADIQARPAM QHVVVTGRGA QPGMIEAADT VTEMSLVKHA FKAGIKAQKG 200
    VEF 203
    Length:203
    Mass (Da):22,292
    Last modified:March 1, 2001 - v1
    Checksum:i2176356693732743
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG04661.1.
    PIRiF83485.
    RefSeqiNP_249963.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG04661; AAG04661; PA1272.
    GeneIDi881408.
    KEGGipae:PA1272.
    PATRICi19836872. VBIPseAer58763_1322.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG04661.1 .
    PIRi F83485.
    RefSeqi NP_249963.1. NC_002516.2.

    3D structure databases

    ProteinModelPortali Q9I472.
    SMRi Q9I472. Positions 33-203.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208964.PA1272.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG04661 ; AAG04661 ; PA1272 .
    GeneIDi 881408.
    KEGGi pae:PA1272.
    PATRICi 19836872. VBIPseAer58763_1322.

    Organism-specific databases

    PseudoCAPi PA1272.

    Phylogenomic databases

    eggNOGi COG2109.
    HOGENOMi HOG000260311.
    KOi K00798.
    OMAi NISWHSL.
    OrthoDBi EOG6GN76J.
    PhylomeDBi Q9I472.

    Enzyme and pathway databases

    UniPathwayi UPA00148 ; UER00233 .

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003724. AdoCbl_synth_CblAdoTrfase_CobA.
    IPR025826. Co_AT_N_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF12557. Co_AT_N. 1 hit.
    PF02572. CobA_CobO_BtuR. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015617. Adensltrnsf_CobA. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00708. cobA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

    Entry informationi

    Entry nameiCOBO_PSEAE
    AccessioniPrimary (citable) accession number: Q9I472
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3