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Q9I472 (COBO_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cob(I)yrinic acid a,c-diamide adenosyltransferase

EC=2.5.1.17
Alternative name(s):
Cob(I)alamin adenosyltransferase
Corrinoid adenosyltransferase
Gene names
Name:cobO
Ordered Locus Names:PA1272
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) [Reference proteome] [HAMAP]
Taxonomic identifier208964 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length203 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids By similarity.

Catalytic activity

ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide.

ATP + cobinamide = triphosphate + adenosylcobinamide.

Cofactor

Manganese By similarity.

Pathway

Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the Cob(I)alamin adenosyltransferase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 203203Cob(I)yrinic acid a,c-diamide adenosyltransferase
PRO_0000287788

Regions

Nucleotide binding41 – 477ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9I472 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 2176356693732743

FASTA20322,292
        10         20         30         40         50         60 
MNESPEKDQR HRERMERKKA VVDEKIAQAR DERGVLLVHS GNGKGKSSSA FGMVARALGH 

        70         80         90        100        110        120 
GMKVGVVQFI KGAASTGEEA FFRRFPEEVS YHVMGEGFTW ETQDRQRDIA KAEAAWKVAA 

       130        140        150        160        170        180 
QLLADPDVGL VVLDELNIAL KHGYLELDRV LADIQARPAM QHVVVTGRGA QPGMIEAADT 

       190        200 
VTEMSLVKHA FKAGIKAQKG VEF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004091 Genomic DNA. Translation: AAG04661.1.
PIRF83485.
RefSeqNP_249963.1. NC_002516.2.

3D structure databases

ProteinModelPortalQ9I472.
SMRQ9I472. Positions 33-203.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING208964.PA1272.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG04661; AAG04661; PA1272.
GeneID881408.
KEGGpae:PA1272.
PATRIC19836872. VBIPseAer58763_1322.

Organism-specific databases

PseudoCAPPA1272.

Phylogenomic databases

eggNOGCOG2109.
HOGENOMHOG000260311.
KOK00798.
OMANISWHSL.
OrthoDBEOG6GN76J.
PhylomeDBQ9I472.

Enzyme and pathway databases

UniPathwayUPA00148; UER00233.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR003724. AdoCbl_synth_CblAdoTrfase_CobA.
IPR025826. Co_AT_N_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF12557. Co_AT_N. 1 hit.
PF02572. CobA_CobO_BtuR. 1 hit.
[Graphical view]
PIRSFPIRSF015617. Adensltrnsf_CobA. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00708. cobA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCOBO_PSEAE
AccessionPrimary (citable) accession number: Q9I472
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways