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Protein

Cobalamin biosynthesis protein CobD

Gene

cobD

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.By similarity

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in the pathway adenosylcobalamin biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCobalamin biosynthesis, Porphyrin biosynthesis

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-1300-MONOMER
UniPathwayiUPA00148

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalamin biosynthesis protein CobD
Gene namesi
Name:cobD
Ordered Locus Names:PA1275
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi

Organism-specific databases

PseudoCAPiPA1275

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002877531 – 312Cobalamin biosynthesis protein CobDAdd BLAST312

Proteomic databases

PaxDbiQ9I469
PRIDEiQ9I469

Interactioni

Protein-protein interaction databases

STRINGi208964.PA1275

Family & Domainsi

Sequence similaritiesi

Belongs to the CobD/CbiB family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DH2 Bacteria
COG1270 LUCA
HOGENOMiHOG000290070
InParanoidiQ9I469
KOiK02227
OMAiDAMVGHR
PhylomeDBiQ9I469

Family and domain databases

HAMAPiMF_00024 CobD_CbiB, 1 hit
InterProiView protein in InterPro
IPR004485 Cobalamin_biosynth_CobD/CbiB
PANTHERiPTHR34308 PTHR34308, 1 hit
PfamiView protein in Pfam
PF03186 CobD_Cbib, 1 hit
TIGRFAMsiTIGR00380 cobD, 1 hit

Sequencei

Sequence statusi: Complete.

Q9I469-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALLGILGV VLDARFGEPQ GWHPLVAFGR LADRLERRFN RSRLAGEADP
60 70 80 90 100
GVGWRSHGVT AWVLAVLPLT LLAWALAELP YLGWLVQALA LYAALGLRSL
110 120 130 140 150
GEHAEPVALA LRAGDLDEAR RRVGYLVSRD TRELDQAGVA RAATESVLEN
160 170 180 190 200
GSDAVYAALF WFAVAGAPGV VLYRLSNTLD AMWGYRNARF ERFGWAAAKI
210 220 230 240 250
DDILNYLPAR LVALTYALLG DTRQALRCWR EQAPQWDSPN AGPVMAAGAG
260 270 280 290 300
ALGVFLGGAA IYHGELHQRP LLGSGPQPQG RDIYRALALV RQGVLLWLLV
310
LAGLWAMGWL HA
Length:312
Mass (Da):33,873
Last modified:March 1, 2001 - v1
Checksum:iC74A880A7F474347
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG04664.1
PIRiA83486
RefSeqiNP_249966.1, NC_002516.2
WP_003112351.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG04664; AAG04664; PA1275
GeneIDi881384
KEGGipae:PA1275
PATRICifig|208964.12.peg.1325

Entry informationi

Entry nameiCOBD_PSEAE
AccessioniPrimary (citable) accession number: Q9I469
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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