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Protein

Threonine-phosphate decarboxylase

Gene

cobC

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.By similarity

Catalytic activityi

L-threonine O-3-phosphate = (R)-1-aminopropan-2-yl phosphate + CO2.

Cofactori

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in the pathway adenosylcobalamin biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Cobalamin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00148.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine-phosphate decarboxylase (EC:4.1.1.81)
Alternative name(s):
L-threonine-O-3-phosphate decarboxylase
Gene namesi
Name:cobC
Ordered Locus Names:PA1276
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA1276.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Threonine-phosphate decarboxylasePRO_0000287744Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei192 – 1921N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PaxDbiQ9I468.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi208964.PA1276.

Structurei

3D structure databases

ProteinModelPortaliQ9I468.
SMRiQ9I468. Positions 4-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105EFT. Bacteria.
COG0079. LUCA.
HOGENOMiHOG000288513.
InParanoidiQ9I468.
KOiK02225.
OMAiAFMDNTP.
PhylomeDBiQ9I468.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR005860. CobD.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01140. L_thr_O3P_dcar. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9I468-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEHGGRLRE AARRYDIPLA DWLDLSTGIA PWPFSLPAIP EQAWTRLPES
60 70 80 90 100
DDGLEAAACL YYGAERVLPL AGSQAAIQAL PRMRRGGRVG VLSPCYAEHA
110 120 130 140 150
HAWRQAGHLV REIGEAEVEP YLDSLDVLLV VNPNNPTGRV FEPAELLAWH
160 170 180 190 200
ARLQRRGGWL LVDEAFMDCT PQSSLAACSN RPGLIVLRSF GKFFGLAGAR
210 220 230 240 250
LGFALGERPL LQALAEQLGP WTVNGPVRHV AQSALRDRQQ QRQQRERLLA
260 270 280 290 300
ASQRLEELLR RHGWPPAGGS ALFQRLVDPR CAALHDYLAR RGILTRQFEQ
310 320 330
PASLRLGLPA DEAAWARLDA ALLGFKEPAH E
Length:331
Mass (Da):36,657
Last modified:March 1, 2001 - v1
Checksum:i5C4D624C54477022
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG04665.1.
PIRiB83486.
RefSeqiNP_249967.1. NC_002516.2.
WP_003112352.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG04665; AAG04665; PA1276.
GeneIDi881414.
KEGGipae:PA1276.
PATRICi19836880. VBIPseAer58763_1326.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG04665.1.
PIRiB83486.
RefSeqiNP_249967.1. NC_002516.2.
WP_003112352.1. NC_002516.2.

3D structure databases

ProteinModelPortaliQ9I468.
SMRiQ9I468. Positions 4-329.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA1276.

Proteomic databases

PaxDbiQ9I468.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG04665; AAG04665; PA1276.
GeneIDi881414.
KEGGipae:PA1276.
PATRICi19836880. VBIPseAer58763_1326.

Organism-specific databases

PseudoCAPiPA1276.

Phylogenomic databases

eggNOGiENOG4105EFT. Bacteria.
COG0079. LUCA.
HOGENOMiHOG000288513.
InParanoidiQ9I468.
KOiK02225.
OMAiAFMDNTP.
PhylomeDBiQ9I468.

Enzyme and pathway databases

UniPathwayiUPA00148.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR005860. CobD.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01140. L_thr_O3P_dcar. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOBC_PSEAE
AccessioniPrimary (citable) accession number: Q9I468
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.