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Q9I406 (GGT_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gamma-glutamyltranspeptidase
EC=2.3.2.2

Cleaved into the following 2 chains:

  1. Gamma-glutamyltranspeptidase large chain
  2. Gamma-glutamyltranspeptidase small chain
Gene names
Name:ggt
Ordered Locus Names:PA1338
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifier208964 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid.

Glutathione + H2O = L-cysteinylglycine + L-glutamate.

Pathway

Sulfur metabolism; glutathione metabolism.

Subunit structure

This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide By similarity.

Subcellular location

Periplasm By similarity.

Sequence similarities

Belongs to the gamma-glutamyltransferase family.

Ontologies

Keywords
   Biological processGlutathione biosynthesis
   Cellular componentPeriplasm
   DomainSignal
   Molecular functionAcyltransferase
Transferase
   PTMZymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processglutathione biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentperiplasmic space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiongamma-glutamyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – ?Gamma-glutamyltranspeptidase large chainPRO_0000287773
Chain? – 557Gamma-glutamyltranspeptidase small chainPRO_0000287774

Sequences

Sequence LengthMass (Da)Tools
Q9I406 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: FDE0DFE595665510

FASTA55759,874
        10         20         30         40         50         60 
MQPVLFRTLS LGVAIAAASS SAFAATLDGG AVAAPDEYGA KVAAQILKAG GNAVDAAVAT 

        70         80         90        100        110        120 
AFTLAVTYPE AGNIGGGGFM TLYMDGKPYF LDYREVAPKA ASKTMYLDDK GEVIENLSLV 

       130        140        150        160        170        180 
GAKAAGVPGT VMGLWEAHKR FGKLPWSELL TPAIGYAQKG FKVADKQFQY RQDAVALFNG 

       190        200        210        220        230        240 
KTNFGDYFGH MKAGEAFLQP DLAKTLERIA DKGPDEFYKG HTADLLVAQM QQDKGLITHQ 

       250        260        270        280        290        300 
DLADYKVRWR EPMRVDWQGN TLYTAPLPSS GGIALAQLLG IKENRAADFK GVELNSARYI 

       310        320        330        340        350        360 
HLLAEIEKRV FADRADYLGD PDFSKVPVAR LTDPAYLKQR AAEVNPTAIS PTEKVRPGLE 

       370        380        390        400        410        420 
PHQTTHFSIV DADGNAVSNT YTLNWDFGSG VVVKGAGFLL NDEMDDFSAK PGVANAFGVV 

       430        440        450        460        470        480 
GSDANAIEPG KRMLSSMSPS IVTRDGKVSL VVGTPGGSRI FTSIFQVLNN IYDFHLPLEK 

       490        500        510        520        530        540 
AVAAQRVHHQ LLPKDTIYYD AYAPLAGKVA EELKAMGYTL EDQGWNMGDI QAIRVDGKAL 

       550 
ETASDPRGRG VGLVVKP

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE004091 Genomic DNA. Translation: AAG04727.1.
PIRD83478.
RefSeqNP_250029.1. NC_002516.2.

3D structure databases

HSSPHSSP built from PDB template 2DG5 based on UniProtKB P18956.
ProteinModelPortalQ9I406.
ModBaseSearch...

Protein family/group databases

MEROPST03.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID882262.
GenomeReviewsGene locus PA1338 in contig AE004091_GR.
KEGGpae:PA1338.
PATRIC19837008. VBIPseAer58763_1390.

Organism-specific databases

PseudoCAPPA1338.

Phylogenomic databases

HOGENOMHBG738311.
OMATRNMYLD.
ProtClustDBCLSK866504.

Enzyme and pathway databases

BioCycPAER208964:PA1338-MONOMER.

Family and domain databases

InterProIPR000101. GGT_peptidase.
[Graphical view]
KOK00681.
PANTHERPTHR11686. GGT_peptidase. 1 hit.
PfamPF01019. G_glu_transpept. 1 hit.
[Graphical view]
PRINTSPR01210. GGTRANSPTASE.
TIGRFAMsTIGR00066. G_glut_trans. 1 hit.
PROSITEPS00462. G_GLU_TRANSPEPTIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGGT_PSEAE
AccessionPrimary (citable) accession number: Q9I406
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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