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Protein

Thiol:disulfide interchange protein DsbE

Gene

dsbE

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cytochrome c-type biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Thiol:disulfide interchange protein DsbE
Alternative name(s):
Cytochrome c biogenesis protein CcmG
Gene namesi
Name:dsbE
Synonyms:ccmG
Ordered Locus Names:PA1481
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA1481.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4CytoplasmicSequence analysis4
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Topological domaini26 – 180PeriplasmicSequence analysisAdd BLAST155

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002012981 – 180Thiol:disulfide interchange protein DsbEAdd BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi74 ↔ 77Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9I3N1.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA1481.

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi28 – 30Combined sources3
Turni32 – 37Combined sources6
Beta strandi44 – 49Combined sources6
Beta strandi53 – 56Combined sources4
Helixi57 – 60Combined sources4
Beta strandi65 – 70Combined sources6
Helixi75 – 89Combined sources15
Beta strandi93 – 100Combined sources8
Helixi103 – 112Combined sources10
Beta strandi118 – 123Combined sources6
Helixi127 – 132Combined sources6
Beta strandi139 – 143Combined sources5
Beta strandi148 – 155Combined sources8
Helixi159 – 165Combined sources7
Helixi167 – 174Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KH7X-ray1.75A26-180[»]
3KH9X-ray2.20A26-180[»]
ProteinModelPortaliQ9I3N1.
SMRiQ9I3N1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9I3N1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 175ThioredoxinPROSITE-ProRule annotationAdd BLAST142

Sequence similaritiesi

Belongs to the thioredoxin family. DsbE subfamily.Curated
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107QX9. Bacteria.
COG0526. LUCA.
HOGENOMiHOG000097218.
InParanoidiQ9I3N1.
KOiK02199.
OMAiKWLAEFH.
PhylomeDBiQ9I3N1.

Family and domain databases

CDDicd03010. TlpA_like_DsbE. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR004799. Periplasmic_diS_OxRdtase_DsbE.
IPR013740. Redoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF08534. Redoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00385. dsbE. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9I3N1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRAILLLPL GIFLIVAVFL FRGLWLDPSE LPSALIGKPF PAFDLPSVQD
60 70 80 90 100
PARRLTEADL KGKPALVNVW GTWCPSCRVE HPELTRLAEQ GVVIYGINYK
110 120 130 140 150
DDNAAAIKWL NELHNPYLLS ISDADGTLGL DLGVYGAPET YLIDKQGIIR
160 170 180
HKIVGVVDQK VWREQLAPLY QQLLDEPEAR
Length:180
Mass (Da):20,122
Last modified:March 1, 2001 - v1
Checksum:i6C85E368106673F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG04870.1.
PIRiB83460.
RefSeqiNP_250172.1. NC_002516.2.
WP_003083138.1. NZ_ASJY01000223.1.

Genome annotation databases

EnsemblBacteriaiAAG04870; AAG04870; PA1481.
GeneIDi881065.
KEGGipae:PA1481.
PATRICi19837292. VBIPseAer58763_1532.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG04870.1.
PIRiB83460.
RefSeqiNP_250172.1. NC_002516.2.
WP_003083138.1. NZ_ASJY01000223.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KH7X-ray1.75A26-180[»]
3KH9X-ray2.20A26-180[»]
ProteinModelPortaliQ9I3N1.
SMRiQ9I3N1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA1481.

Proteomic databases

PaxDbiQ9I3N1.

Protocols and materials databases

DNASUi881065.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG04870; AAG04870; PA1481.
GeneIDi881065.
KEGGipae:PA1481.
PATRICi19837292. VBIPseAer58763_1532.

Organism-specific databases

PseudoCAPiPA1481.

Phylogenomic databases

eggNOGiENOG4107QX9. Bacteria.
COG0526. LUCA.
HOGENOMiHOG000097218.
InParanoidiQ9I3N1.
KOiK02199.
OMAiKWLAEFH.
PhylomeDBiQ9I3N1.

Miscellaneous databases

EvolutionaryTraceiQ9I3N1.

Family and domain databases

CDDicd03010. TlpA_like_DsbE. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR004799. Periplasmic_diS_OxRdtase_DsbE.
IPR013740. Redoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF08534. Redoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00385. dsbE. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDSBE_PSEAE
AccessioniPrimary (citable) accession number: Q9I3N1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.