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Q9I3F5 (ACON1_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aconitate hydratase 1
Short name=Aconitase 1
EC=4.2.1.3
Alternative name(s):
Citrate hydro-lyase 1
Gene names
Name:acnA
Ordered Locus Names:PA1562
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) [Reference proteome] [HAMAP]
Taxonomic identifier208964 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas ›

Protein attributes

Sequence length910 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate By similarity.

Catalytic activity

Citrate = isocitrate.

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.

Sequence similarities

Belongs to the aconitase/IPM isomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 910910Aconitate hydratase 1
PRO_0000287739

Sites

Metal binding4541Iron-sulfur (4Fe-4S) By similarity
Metal binding5201Iron-sulfur (4Fe-4S) By similarity
Metal binding5231Iron-sulfur (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9I3F5 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: C65F23CDB6FA0E1C

FASTA91099,148
        10         20         30         40         50         60 
MPALDSLKTL RSLAVDGKTY HYYSLPEAAR TLGDLGKLPM SLKVLLENLL RWEDGSTVTG 

        70         80         90        100        110        120 
DDLKALAGWL RERRSDREIQ YRPARVLMQD FTGVPAVVDL AAMRAAMAKA GGDPQKINPL 

       130        140        150        160        170        180 
SPVDLVIDHS VMVDKFASES AFEQNVEIEM QRNGERYAFL RWGQNAFDNF SVVPPGTGIC 

       190        200        210        220        230        240 
HQVNLEYLGR TVWTKDEDGR TYAFPDTLVG TDSHTTMING LGVLGWGVGG IEAEAAMLGQ 

       250        260        270        280        290        300 
PVSMLIPEVI GFKLTGKLRE GITATDLVLT VTQMLRKKGV VGKFVEFYGD GLADLPLADR 

       310        320        330        340        350        360 
ATIANMAPEY GATCGFFPVD EITLGYLRLS GRPESTVKLV EAYSKEQGLW REKGHEPVFT 

       370        380        390        400        410        420 
DTLHLDMGEV EASLAGPKRP QDRVALQNVA SAFNEFLGLQ LHPSSTEEGR LLSEGGGGTA 

       430        440        450        460        470        480 
VGANAAFGEI DYQHDGQTHR LKNGAVVIAA ITSCTNTSNP SVMMAAGLLA KKAVEKGLQR 

       490        500        510        520        530        540 
KPWVKSSLAP GSKVVTDYFK AAGLTRYLDE LGFDLVGYGC TTCIGNSGPL LEPIEKAIQQ 

       550        560        570        580        590        600 
ADLTVASVLS GNRNFEGRVH PLVKTNWLAS PPLVVAYALA GSVRINLSEE PLGTGKDGQP 

       610        620        630        640        650        660 
VYLKDIWPSQ KEIAEAIQKV DTEMFHKEYA EVFAGDEKWQ AIQVPQSDTY EWQADSTYIQ 

       670        680        690        700        710        720 
HPPFFEHIAE APPAIADVEQ ARVLAVLGDS VTTDHISPAG NIKADSPAGR YLREHGVEPK 

       730        740        750        760        770        780 
DFNSYGSRRG NHEVMMRGTF ANIRIKNEML GGEEGGNTLY VPSGEKLAIY DAAMRYQEDG 

       790        800        810        820        830        840 
TPLVIVAGKE YGTGSSRDWA AKGTNLLGVK AVIAESFERI HRSNLVGMGV LPLQFENGQD 

       850        860        870        880        890        900 
RKSLKLTGKE VLNIRGLGGE LKPHMPLSVE VTREDGSQDS FKVLCRIDTL NEVEYFKAGG 

       910 
ILHYVLRSML

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE004091 Genomic DNA. Translation: AAG04951.1.
PIRB83451.
RefSeqNP_250253.1. NC_002516.2.

3D structure databases

HSSPHSSP built from PDB template 2B3Y based on UniProtKB P21399.
ProteinModelPortalQ9I3F5.
SMRQ9I3F5. Positions 36-909.
ModBaseSearch...

Protein-protein interaction databases

STRING208964.PA1562.

Proteomic databases

PRIDEQ9I3F5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID879412.
KEGGpae:PA1562.
PATRIC19837464. VBIPseAer58763_1618.

Organism-specific databases

PseudoCAPPA1562.

Phylogenomic databases

eggNOGCOG1048.
HOGENOMHOG000025703.
KOK01681.
OMAYSKAQGM.
ProtClustDBPRK12881.

Enzyme and pathway databases

UniPathwayUPA00223; UER00718.

Family and domain databases

Gene3D3.20.19.10. 1 hit.
3.30.499.10. 3 hits.
3.40.1060.10. 1 hit.
InterProIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR006249. Aconitase/Fe_reg_prot_2.
IPR015934. Aconitase/Fe_reg_prot_2/AcnD.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
PANTHERPTHR11670. PTHR11670. 1 hit.
PTHR11670:SF1. PTHR11670:SF1. 1 hit.
PfamPF00330. Aconitase. 2 hits.
PF00694. Aconitase_C. 1 hit.
[Graphical view]
PRINTSPR00415. ACONITASE.
SUPFAMSSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
SSF53732. Aconitase_N. 1 hit.
TIGRFAMsTIGR01341. aconitase_1. 1 hit.
PROSITEPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACON1_PSEAE
AccessionPrimary (citable) accession number: Q9I3F5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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