Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9I351

- GCH12_PSEAE

UniProt

Q9I351 - GCH12_PSEAE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

GTP cyclohydrolase 1 2

Gene

folE2

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.

Pathwayi

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. one-carbon metabolic process Source: UniProtKB-HAMAP
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1 2 (EC:3.5.4.16)
Alternative name(s):
GTP cyclohydrolase I 2
Short name:
GTP-CH-I 2
Gene namesi
Name:folE2
Ordered Locus Names:PA1674
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA1674.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181GTP cyclohydrolase 1 2PRO_0000119429Add
BLAST

Interactioni

Subunit structurei

Homopolymer.By similarity

Protein-protein interaction databases

STRINGi208964.PA1674.

Structurei

3D structure databases

ProteinModelPortaliQ9I351.
SMRiQ9I351. Positions 11-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase I family.Curated

Phylogenomic databases

eggNOGiCOG0302.
HOGENOMiHOG000221222.
KOiK01495.
OMAiKRTYDEE.
OrthoDBiEOG6XHC8G.
PhylomeDBiQ9I351.

Family and domain databases

HAMAPiMF_00223. FolE.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9I351-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLEQHYSSI LTQLGEDVNR EGLLDTPKRA AKAMKYLCRG YQQSLEEVVN
60 70 80 90 100
GALFSSDNSE MVLVKDIELY SLCEHHLLPF IGKAHVAYIP NGKVLGLSKV
110 120 130 140 150
ARIVDMYARR LQIQENMSRQ IAEAVQQVTG ALGVAVVIQA QHMCMMMRGV
160 170 180
EKQNSSMVTS VMLGEFRDNA ATRSEFLSLI R
Length:181
Mass (Da):20,236
Last modified:March 1, 2001 - v1
Checksum:iAE63943491AA7BC3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG05063.1.
PIRiC83435.
RefSeqiNP_250365.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG05063; AAG05063; PA1674.
GeneIDi879308.
KEGGipae:PA1674.
PATRICi19837699. VBIPseAer58763_1735.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG05063.1 .
PIRi C83435.
RefSeqi NP_250365.1. NC_002516.2.

3D structure databases

ProteinModelPortali Q9I351.
SMRi Q9I351. Positions 11-181.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA1674.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG05063 ; AAG05063 ; PA1674 .
GeneIDi 879308.
KEGGi pae:PA1674.
PATRICi 19837699. VBIPseAer58763_1735.

Organism-specific databases

PseudoCAPi PA1674.

Phylogenomic databases

eggNOGi COG0302.
HOGENOMi HOG000221222.
KOi K01495.
OMAi KRTYDEE.
OrthoDBi EOG6XHC8G.
PhylomeDBi Q9I351.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .

Family and domain databases

HAMAPi MF_00223. FolE.
InterProi IPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view ]
PANTHERi PTHR11109. PTHR11109. 1 hit.
Pfami PF01227. GTP_cyclohydroI. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00063. folE. 1 hit.
PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiGCH12_PSEAE
AccessioniPrimary (citable) accession number: Q9I351
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: March 1, 2001
Last modified: October 1, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3