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Q9I340 (MTNC_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Enolase-phosphatase E1
EC=3.1.3.77
Alternative name(s):
2,3-diketo-5-methylthio-1-phosphopentane phosphatase
Gene names
Name:mtnC
Ordered Locus Names:PA1685
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifier208964 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length249 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) By similarity. HAMAP MF_01681

Catalytic activity

5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. HAMAP MF_01681

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP MF_01681

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6. HAMAP MF_01681

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6.

Subunit structure

Monomer By similarity. HAMAP MF_01681

Sequence similarities

Belongs to the HAD-like hydrolase superfamily. MasA/mtnC family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 249249Enolase-phosphatase E1 HAMAP MF_01681
PRO_0000357387

Sequences

Sequence LengthMass (Da)Tools
Q9I340 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 0758BF9D5BFDF0F6

FASTA24926,472
        10         20         30         40         50         60 
MTIKAILTDI EGTTSAVSFV FDVLFPYAAR HLPDFVREHA GETEVAAQLA AVRAESGEAD 

        70         80         90        100        110        120 
ADVERVIAIL LQWIAEDRKA TPLKALQGMV WAQGYRDGQL KGHVYPDAVQ ALREWKARGL 

       130        140        150        160        170        180 
DLYVYSSGSI QAQKLIFGCS EAGDLGSLFS GYFDTTSGPK RESASYARIA GAIGLPAAEI 

       190        200        210        220        230        240 
LFLSDVVQEL DAARDAGMRT LGLAREGGSL DGHPTVASSP TSSWSERAGY PEGTLLLGSI 


APWVPPSAG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE004091 Genomic DNA. Translation: AAG05074.1.
PIRF83436.
RefSeqNP_250376.1. NC_002516.2.

3D structure databases

HSSPHSSP built from PDB template 2G80 based on UniProtKB P32626.
ProteinModelPortalQ9I340.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID878111.
GenomeReviewsGene locus PA1685 in contig AE004091_GR.
KEGGpae:PA1685.
NMPDRfig|208964.1.peg.1686.
PATRIC19837721. VBIPseAer58763_1746.

Organism-specific databases

PseudoCAPPA1685.

Phylogenomic databases

HOGENOMHBG294242.
OMATTDLNFI.
ProtClustDBCLSK866737.

Enzyme and pathway databases

BioCycPAER208964:PA1685-MONOMER.

Family and domain databases

HAMAPMF_01681. Salvage_MtnC.
[Tree]
InterProIPR005834. Dehalogen-like_hydro.
IPR023943. Enolase-phosphatase_E1.
IPR010041. Enolase_ppase.
IPR023214. HAD-like_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.1000. HAD-like_dom. 1 hit.
KOK09880.
PfamPF00702. Hydrolase. 1 hit.
[Graphical view]
SUPFAMSSF56784. HAD-like_dom. 1 hit.
TIGRFAMsTIGR01691. Enolase-ppase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMTNC_PSEAE
AccessionPrimary (citable) accession number: Q9I340
Entry history
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: March 1, 2001
Last modified: January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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