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Protein

Phosphoenolpyruvate synthase

Gene

ppsA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.UniRule annotation

Catalytic activityi

ATP + pyruvate + H2O = AMP + phosphoenolpyruvate + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • gluconeogenesis Source: PseudoCAP
  • pyruvate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, PyruvateImported

Enzyme and pathway databases

UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate synthaseUniRule annotation (EC:2.7.9.2UniRule annotation)
Short name:
PEP synthaseUniRule annotation
Alternative name(s):
Pyruvate, water dikinaseUniRule annotation
Gene namesi
Name:ppsAImported
Ordered Locus Names:PA1770Imported
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)Imported
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA1770.

PTM / Processingi

Proteomic databases

PaxDbiQ9I2W9.
PRIDEiQ9I2W9.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA1770.

Structurei

3D structure databases

ProteinModelPortaliQ9I2W9.
SMRiQ9I2W9. Positions 4-785.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 342326PPDK_NInterPro annotationAdd
BLAST
Domaini383 – 45472PEP-utilizersInterPro annotationAdd
BLAST
Domaini481 – 780300PEP-utilizers_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PEP-utilizing enzyme family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108HRN. Bacteria.
COG0574. LUCA.
HOGENOMiHOG000230912.
InParanoidiQ9I2W9.
KOiK01007.
OMAiMVIEKHY.
OrthoDBiEOG632CZ4.
PhylomeDBiQ9I2W9.

Family and domain databases

Gene3Di3.20.20.60. 1 hit.
3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.50.30.10. 1 hit.
InterProiIPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR008279. PEP-util_enz_mobile_dom.
IPR006319. PEP_synth.
IPR018274. PEP_util_AS.
IPR000121. PEP_util_C.
IPR023151. PEP_util_CS.
IPR002192. PPDK_PEP-bd.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00391. PEP-utilizers. 1 hit.
PF02896. PEP-utilizers_C. 1 hit.
PF01326. PPDK_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000854. PEP_synthase. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
SSF52009. SSF52009. 1 hit.
TIGRFAMsiTIGR01418. PEP_synth. 1 hit.
PROSITEiPS00742. PEP_ENZYMES_2. 1 hit.
PS00370. PEP_ENZYMES_PHOS_SITE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9I2W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEYVVSLDK LGVHDVEHVG GKNASLGEMI SNLAGAGVSV PGGFATTAQA
60 70 80 90 100
YRDFLEQSGL NDRIHAALDA LDVDDVNALA KTGAQIRQWV MEAEFPARLD
110 120 130 140 150
SEIRQAFAAL ANGNDNLAVA VRSSATAEDL PDASFAGQQE TFLNIRGVDN
160 170 180 190 200
VIRAAKEVFA SLFNDRAIAY RVHQGFDHKL VALSAGVQRM VRSETGTAGV
210 220 230 240 250
MFTLDTESGF RDVVFITGAY GLGETVVQGA VNPDEFYVHK PTLEAGRPAI
260 270 280 290 300
LRRNLGSKAI KMIYGDEAKA GRSVKVVDVD RADRARFALS DAEVTELAKQ
310 320 330 340 350
AMIIEKHYGR PMDIEWAKDG DDGKLYIVQA RPETVKSRAS ATVMERYLLK
360 370 380 390 400
EKGTVLVEGR AIGQRIGAGP VKVINDVSEM DKVQPGDVLV SDMTDPDWEP
410 420 430 440 450
VMKRASAIVT NRGGRTCHAA IIARELGIPA VVGCGNATQI LQDGQGVTVS
460 470 480 490 500
CAEGDTGFIF EGELGFDVRK NSVDAMPDLP FKIMMNVGNP DRAFDFAQLP
510 520 530 540 550
NEGVGLARLE FIINRMIGVH PKALLNFAGL PADIKESVEK RIAGYPDPVG
560 570 580 590 600
FYVEKLVEGI STLAAAFWPK KVIVRLSDFK SNEYANLIGG KLYEPEEENP
610 620 630 640 650
MLGFRGASRY ISESFRDCFE LECRALKKVR NEMGLTNVEI MVPFVRTLGE
660 670 680 690 700
ASQVVELLAG NGLKRGENGL KVIMMCELPS NALLADEFLE FFDGFSIGSN
710 720 730 740 750
DLTQLTLGLD RDSGIVAHLF DERNPAVKKL LANAIAACNK AGKYIGICGQ
760 770 780 790
GPSDHPDLAR WLMEQGIESV SLNPDSVLDT WFFLAEGQDQ A
Length:791
Mass (Da):85,817
Last modified:March 1, 2001 - v1
Checksum:iF606FB53A0FD5B51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG05159.1.
PIRiE83425.
RefSeqiNP_250461.1. NC_002516.2.
WP_003098065.1. NZ_ASJY01000250.1.

Genome annotation databases

EnsemblBacteriaiAAG05159; AAG05159; PA1770.
GeneIDi878597.
KEGGipae:PA1770.
PATRICi19837899. VBIPseAer58763_1835.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG05159.1.
PIRiE83425.
RefSeqiNP_250461.1. NC_002516.2.
WP_003098065.1. NZ_ASJY01000250.1.

3D structure databases

ProteinModelPortaliQ9I2W9.
SMRiQ9I2W9. Positions 4-785.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA1770.

Proteomic databases

PaxDbiQ9I2W9.
PRIDEiQ9I2W9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG05159; AAG05159; PA1770.
GeneIDi878597.
KEGGipae:PA1770.
PATRICi19837899. VBIPseAer58763_1835.

Organism-specific databases

PseudoCAPiPA1770.

Phylogenomic databases

eggNOGiENOG4108HRN. Bacteria.
COG0574. LUCA.
HOGENOMiHOG000230912.
InParanoidiQ9I2W9.
KOiK01007.
OMAiMVIEKHY.
OrthoDBiEOG632CZ4.
PhylomeDBiQ9I2W9.

Enzyme and pathway databases

UniPathwayiUPA00138.

Family and domain databases

Gene3Di3.20.20.60. 1 hit.
3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.50.30.10. 1 hit.
InterProiIPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR008279. PEP-util_enz_mobile_dom.
IPR006319. PEP_synth.
IPR018274. PEP_util_AS.
IPR000121. PEP_util_C.
IPR023151. PEP_util_CS.
IPR002192. PPDK_PEP-bd.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00391. PEP-utilizers. 1 hit.
PF02896. PEP-utilizers_C. 1 hit.
PF01326. PPDK_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000854. PEP_synthase. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
SSF52009. SSF52009. 1 hit.
TIGRFAMsiTIGR01418. PEP_synth. 1 hit.
PROSITEiPS00742. PEP_ENZYMES_2. 1 hit.
PS00370. PEP_ENZYMES_PHOS_SITE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228Imported.

Entry informationi

Entry nameiQ9I2W9_PSEAE
AccessioniPrimary (citable) accession number: Q9I2W9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.