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Q9I2W4

- SUMT_PSEAE

UniProt

Q9I2W4 - SUMT_PSEAE

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Protein

Uroporphyrinogen-III C-methyltransferase

Gene
cobA, PA1778
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin By similarity.

Catalytic activityi

S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.
S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

Pathwayi

GO - Molecular functioni

  1. precorrin-2 dehydrogenase activity Source: InterPro
  2. uroporphyrin-III C-methyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. cobalamin biosynthetic process Source: UniProtKB-UniPathway
  2. siroheme biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Cobalamin biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00148; UER00211.
UPA00262; UER00211.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen-III C-methyltransferase (EC:2.1.1.107)
Short name:
Urogen III methylase
Alternative name(s):
SUMT
Uroporphyrinogen III methylase
Short name:
UROM
Gene namesi
Name:cobA
Ordered Locus Names:PA1778
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA1778.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245Uroporphyrinogen-III C-methyltransferasePRO_0000287818Add
BLAST

Interactioni

Subunit structurei

Monomer Inferred.

Protein-protein interaction databases

STRINGi208964.PA1778.

Structurei

3D structure databases

ProteinModelPortaliQ9I2W4.
SMRiQ9I2W4. Positions 2-232.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0007.
HOGENOMiHOG000290519.
KOiK02303.
OMAiFIEKLML.
OrthoDBiEOG6DRPFR.
PhylomeDBiQ9I2W4.

Family and domain databases

Gene3Di3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
InterProiIPR000878. 4pyrrol_Mease.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR006366. CobA/CysG_C.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view]
PfamiPF00590. TP_methylase. 1 hit.
[Graphical view]
SUPFAMiSSF53790. SSF53790. 1 hit.
TIGRFAMsiTIGR01469. cobA_cysG_Cterm. 1 hit.
PROSITEiPS00839. SUMT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9I2W4-1 [UniParc]FASTAAdd to Basket

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MSGKVWLVGA GPGDPELLTL KAVRALQDAD VVMVDDLVNP SILEHCPSAR    50
LVRVGKRGGC RSTPQDFIQR LMLRHARQGR SVVRLKGGDP CIFGRAGEEA 100
EWLARHGIDS EIVNGITAGL AGATACGIPL TYRGISRGVT LVTAHTQDDS 150
PLAWEALARS GTTLVVYMGV ARLAEIQAGL LAGGMAEDTP LAMIENATLG 200
NQRECRSNLG ELLRDAGRFA LKSPAILVIG EVTRDIVSQP ISLSA 245
Length:245
Mass (Da):25,925
Last modified:March 1, 2001 - v1
Checksum:i7BB11C9942E56F7F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG05167.1.
PIRiH83423.
RefSeqiNP_250469.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG05167; AAG05167; PA1778.
GeneIDi877770.
KEGGipae:PA1778.
PATRICi19837915. VBIPseAer58763_1843.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG05167.1 .
PIRi H83423.
RefSeqi NP_250469.1. NC_002516.2.

3D structure databases

ProteinModelPortali Q9I2W4.
SMRi Q9I2W4. Positions 2-232.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA1778.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG05167 ; AAG05167 ; PA1778 .
GeneIDi 877770.
KEGGi pae:PA1778.
PATRICi 19837915. VBIPseAer58763_1843.

Organism-specific databases

PseudoCAPi PA1778.

Phylogenomic databases

eggNOGi COG0007.
HOGENOMi HOG000290519.
KOi K02303.
OMAi FIEKLML.
OrthoDBi EOG6DRPFR.
PhylomeDBi Q9I2W4.

Enzyme and pathway databases

UniPathwayi UPA00148 ; UER00211 .
UPA00262 ; UER00211 .

Family and domain databases

Gene3Di 3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
InterProi IPR000878. 4pyrrol_Mease.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR006366. CobA/CysG_C.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view ]
Pfami PF00590. TP_methylase. 1 hit.
[Graphical view ]
SUPFAMi SSF53790. SSF53790. 1 hit.
TIGRFAMsi TIGR01469. cobA_cysG_Cterm. 1 hit.
PROSITEi PS00839. SUMT_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiSUMT_PSEAE
AccessioniPrimary (citable) accession number: Q9I2W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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