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Q9I2W4

- SUMT_PSEAE

UniProt

Q9I2W4 - SUMT_PSEAE

Protein

Uroporphyrinogen-III C-methyltransferase

Gene

cobA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.
    S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

    Pathwayi

    GO - Molecular functioni

    1. precorrin-2 dehydrogenase activity Source: InterPro
    2. uroporphyrin-III C-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cobalamin biosynthetic process Source: UniProtKB-UniPathway
    2. siroheme biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Cobalamin biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    UniPathwayiUPA00148; UER00211.
    UPA00262; UER00211.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uroporphyrinogen-III C-methyltransferase (EC:2.1.1.107)
    Short name:
    Urogen III methylase
    Alternative name(s):
    SUMT
    Uroporphyrinogen III methylase
    Short name:
    UROM
    Gene namesi
    Name:cobA
    Ordered Locus Names:PA1778
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA1778.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 245245Uroporphyrinogen-III C-methyltransferasePRO_0000287818Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.Curated

    Protein-protein interaction databases

    STRINGi208964.PA1778.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9I2W4.
    SMRiQ9I2W4. Positions 2-232.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the precorrin methyltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG0007.
    HOGENOMiHOG000290519.
    KOiK02303.
    OMAiFIEKLML.
    OrthoDBiEOG6DRPFR.
    PhylomeDBiQ9I2W4.

    Family and domain databases

    Gene3Di3.30.950.10. 1 hit.
    3.40.1010.10. 1 hit.
    InterProiIPR000878. 4pyrrol_Mease.
    IPR014777. 4pyrrole_Mease_sub1.
    IPR014776. 4pyrrole_Mease_sub2.
    IPR006366. CobA/CysG_C.
    IPR003043. Uropor_MeTrfase_CS.
    [Graphical view]
    PfamiPF00590. TP_methylase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53790. SSF53790. 1 hit.
    TIGRFAMsiTIGR01469. cobA_cysG_Cterm. 1 hit.
    PROSITEiPS00839. SUMT_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9I2W4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGKVWLVGA GPGDPELLTL KAVRALQDAD VVMVDDLVNP SILEHCPSAR    50
    LVRVGKRGGC RSTPQDFIQR LMLRHARQGR SVVRLKGGDP CIFGRAGEEA 100
    EWLARHGIDS EIVNGITAGL AGATACGIPL TYRGISRGVT LVTAHTQDDS 150
    PLAWEALARS GTTLVVYMGV ARLAEIQAGL LAGGMAEDTP LAMIENATLG 200
    NQRECRSNLG ELLRDAGRFA LKSPAILVIG EVTRDIVSQP ISLSA 245
    Length:245
    Mass (Da):25,925
    Last modified:March 1, 2001 - v1
    Checksum:i7BB11C9942E56F7F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG05167.1.
    PIRiH83423.
    RefSeqiNP_250469.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG05167; AAG05167; PA1778.
    GeneIDi877770.
    KEGGipae:PA1778.
    PATRICi19837915. VBIPseAer58763_1843.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG05167.1 .
    PIRi H83423.
    RefSeqi NP_250469.1. NC_002516.2.

    3D structure databases

    ProteinModelPortali Q9I2W4.
    SMRi Q9I2W4. Positions 2-232.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208964.PA1778.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG05167 ; AAG05167 ; PA1778 .
    GeneIDi 877770.
    KEGGi pae:PA1778.
    PATRICi 19837915. VBIPseAer58763_1843.

    Organism-specific databases

    PseudoCAPi PA1778.

    Phylogenomic databases

    eggNOGi COG0007.
    HOGENOMi HOG000290519.
    KOi K02303.
    OMAi FIEKLML.
    OrthoDBi EOG6DRPFR.
    PhylomeDBi Q9I2W4.

    Enzyme and pathway databases

    UniPathwayi UPA00148 ; UER00211 .
    UPA00262 ; UER00211 .

    Family and domain databases

    Gene3Di 3.30.950.10. 1 hit.
    3.40.1010.10. 1 hit.
    InterProi IPR000878. 4pyrrol_Mease.
    IPR014777. 4pyrrole_Mease_sub1.
    IPR014776. 4pyrrole_Mease_sub2.
    IPR006366. CobA/CysG_C.
    IPR003043. Uropor_MeTrfase_CS.
    [Graphical view ]
    Pfami PF00590. TP_methylase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53790. SSF53790. 1 hit.
    TIGRFAMsi TIGR01469. cobA_cysG_Cterm. 1 hit.
    PROSITEi PS00839. SUMT_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

    Entry informationi

    Entry nameiSUMT_PSEAE
    AccessioniPrimary (citable) accession number: Q9I2W4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3