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Q9I2W4 (SUMT_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uroporphyrinogen-III C-methyltransferase

Short name=Urogen III methylase
EC=2.1.1.107
Alternative name(s):
SUMT
Uroporphyrinogen III methylase
Short name=UROM
Gene names
Name:cobA
Ordered Locus Names:PA1778
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) [Reference proteome] [HAMAP]
Taxonomic identifier208964 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin By similarity.

Catalytic activity

S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.

S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

Pathway

Cofactor biosynthesis; adenosylcobalamin biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1.

Porphyrin-containing compound metabolism; siroheme biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1.

Subunit structure

Monomer Probable.

Sequence similarities

Belongs to the precorrin methyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 245245Uroporphyrinogen-III C-methyltransferase
PRO_0000287818

Sequences

Sequence LengthMass (Da)Tools
Q9I2W4 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 7BB11C9942E56F7F

FASTA24525,925
        10         20         30         40         50         60 
MSGKVWLVGA GPGDPELLTL KAVRALQDAD VVMVDDLVNP SILEHCPSAR LVRVGKRGGC 

        70         80         90        100        110        120 
RSTPQDFIQR LMLRHARQGR SVVRLKGGDP CIFGRAGEEA EWLARHGIDS EIVNGITAGL 

       130        140        150        160        170        180 
AGATACGIPL TYRGISRGVT LVTAHTQDDS PLAWEALARS GTTLVVYMGV ARLAEIQAGL 

       190        200        210        220        230        240 
LAGGMAEDTP LAMIENATLG NQRECRSNLG ELLRDAGRFA LKSPAILVIG EVTRDIVSQP 


ISLSA 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004091 Genomic DNA. Translation: AAG05167.1.
PIRH83423.
RefSeqNP_250469.1. NC_002516.2.

3D structure databases

ProteinModelPortalQ9I2W4.
SMRQ9I2W4. Positions 2-232.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING208964.PA1778.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID877770.
KEGGpae:PA1778.
PATRIC19837915. VBIPseAer58763_1843.

Organism-specific databases

PseudoCAPPA1778.

Phylogenomic databases

eggNOGCOG0007.
HOGENOMHOG000290519.
KOK02303.
OMAFIHRLML.
OrthoDBEOG6DRPFR.
ProtClustDBPRK06136.

Enzyme and pathway databases

UniPathwayUPA00148; UER00211.
UPA00262; UER00211.

Family and domain databases

Gene3D3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
InterProIPR000878. 4pyrrol_Mease.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR006366. CobA/CysG_C.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view]
PfamPF00590. TP_methylase. 1 hit.
[Graphical view]
SUPFAMSSF53790. SSF53790. 1 hit.
TIGRFAMsTIGR01469. cobA_cysG_Cterm. 1 hit.
PROSITEPS00839. SUMT_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSUMT_PSEAE
AccessionPrimary (citable) accession number: Q9I2W4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways