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Q9I2E5

- UPPP_PSEAE

UniProt

Q9I2E5 - UPPP_PSEAE

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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Synonyms:bacA, upk
Ordered Locus Names:PA1959
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA1959.

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei47 – 6721HelicalUniRule annotationAdd
BLAST
Transmembranei85 – 10521HelicalUniRule annotationAdd
BLAST
Transmembranei108 – 12821HelicalUniRule annotationAdd
BLAST
Transmembranei187 – 20721HelicalUniRule annotationAdd
BLAST
Transmembranei218 – 23821HelicalUniRule annotationAdd
BLAST
Transmembranei249 – 26921HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277Undecaprenyl-diphosphatasePRO_0000151181Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi208964.PA1959.

Structurei

3D structure databases

ProteinModelPortaliQ9I2E5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
InParanoidiQ9I2E5.
KOiK06153.
OMAiFNDAHAK.
OrthoDBiEOG6QP13M.
PhylomeDBiQ9I2E5.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9I2E5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEWWTAFQAF ILGVVEGLTE FLPISSTGHQ IIVADLIGFG GERAKAFNII
60 70 80 90 100
IQLAAILAVV WEFRGKIFQV VRDLPSQRQA QRFTANLLIA FFPAVVLGVL
110 120 130 140 150
FADLIHEWLF NPITVALALV VGGVVMLWAE RRKHVIRAEH VDDMTWKDAL
160 170 180 190 200
KIGCAQCLAM IPGTSRSGAT IIGGLLFGLS RKAATEFSFF LAMPTMVGAA
210 220 230 240 250
VYSGYVYRDL FRPEDLPVFA VGFVTSFVFA MLAVRALLKF IGNHSYAAFA
260 270
WYRIAFGLLI LATWQFHLID WSTAGEV
Length:277
Mass (Da):30,724
Last modified:March 1, 2001 - v1
Checksum:i52DBB5917B8583CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG05347.1.
PIRiF83401.
RefSeqiNP_250649.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG05347; AAG05347; PA1959.
GeneIDi877690.
KEGGipae:PA1959.
PATRICi19838323. VBIPseAer58763_2042.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG05347.1 .
PIRi F83401.
RefSeqi NP_250649.1. NC_002516.2.

3D structure databases

ProteinModelPortali Q9I2E5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA1959.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG05347 ; AAG05347 ; PA1959 .
GeneIDi 877690.
KEGGi pae:PA1959.
PATRICi 19838323. VBIPseAer58763_2042.

Organism-specific databases

PseudoCAPi PA1959.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
InParanoidi Q9I2E5.
KOi K06153.
OMAi FNDAHAK.
OrthoDBi EOG6QP13M.
PhylomeDBi Q9I2E5.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiUPPP_PSEAE
AccessioniPrimary (citable) accession number: Q9I2E5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3