Reviewed, UniProtKB/Swiss-Prot Q9I2C2 (PQQC_PSEAE)

Names and origin

Protein names

Recommended name:
    Pyrroloquinoline-quinone synthase
    EC=1.3.3.11
Alternative name(s):
    Coenzyme PQQ synthesis protein C
    Pyrroloquinoline quinone biosynthesis protein C

Gene names

Name:	pqqC
Ordered Locus Names:	PA1987

Organism

Pseudomonas aeruginosa [Complete proteome] [HAMAP]

Taxonomic identifier

287 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ By similarity.
Catalytic activity	6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O. HAMAP MF_00654
Pathway	Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis. HAMAP MF_00654
Sequence similarities	Belongs to the pqqC family.

Ontologies

Keywords
Biological process	PQQ biosynthesis
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyrroloquinoline quinone biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	pyrroloquinoline-quinone synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 250	250	Pyrroloquinoline-quinone synthase HAMAP MF_00654		PRO_0000219982

Sequences

	Sequence		Length	Mass (Da)
	Q9I2C2-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 6245E87D0C200E46	FASTA	250	29,449
	10 20 30 40 50 60 MSRAAMDRAE FERALRDKGR YYHIHHPFHV AMYEGRASRE QIQGWVANRF YYQVNIPLKD 70 80 90 100 110 120 AAILANCPDR EVRREWIQRI LDHDGAPGEA GGIEAWLRLA EAVGLEREQV LSEERVLPGV 130 140 150 160 170 180 RFAVDAYVNF ARRASWQEAA SSSLTELFAP QIHQSRLDSW PRHYPWIEAA GYEYFRSRLA 190 200 210 220 230 240 QARRDVEHGL RITLEHYRTR EAQERMLDIL QFKLDVLWSM LDAMSMAYEL ERPPYHTVTR 250 ERVWHRGLAS

References

[1]

"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen." Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. , Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V. Nature 406:959-964(2000) [PubMed: 10984043] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE004091 Genomic DNA. Translation: AAG05375.1.
PIR	C83397.
RefSeq	NP_250677.1.
3D structure databases
SMR	Q9I2C2. Positions 11-245.
ModBase	Search...
Genome annotation databases
GeneID	879112.
GenomeReviews	Gene locus PA1987 in contig AE004091_GR.
KEGG	pae:PA1987.
Organism-specific databases
PseudoCAP	PA1987.
CMR	Search...
Phylogenomic databases
HOGENOM	Q9I2C2.
OMA	Q9I2C2. DSWPQHY.
Enzyme and pathway databases
BioCyc	PAER208964:PA1987-MON.
BRENDA	1.3.3.11. 354.
Family and domain databases
HAMAP	MF_00654. [Tree]
InterPro	IPR016084. Haem_Oase-like_multi-hlx. IPR011845. PQQ_synth_PqqC. IPR004305. TENA/THI4/PQQ_synth_PqqC. [Graphical view]
Gene3D	G3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit.
Pfam	PF03070. TENA_THI-4. 1 hit. [Graphical view]
TIGRFAMs	TIGR02111. PQQ_syn_pqqC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PQQC_PSEAE

Accession

Primary (citable) accession number: Q9I2C2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2003
Last sequence update:	March 1, 2001
Last modified:	June 16, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)