Q9I234 (KYNB_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine formamidase
Short name=KFA
EC=3.5.1.9

Alternative name(s):
N-formylkynurenine formamidase

Gene names

Name:	kynB
Ordered Locus Names:	PA2081

Organism

Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

Taxonomic identifier

208964 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine. Ref.2
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine. Ref.2
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the kynB family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	anthranilate metabolic process Inferred from genomic context Ref.2. Source: UniProtKB tryptophan catabolic process to kynurenine Inferred from genomic context Ref.2. Source: UniProtKB
Molecular function	arylformamidase activity Inferred from direct assay Ref.2. Source: UniProtKB formamidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Kynurenine formamidase		PRO_0000362130

Sequences

	Sequence		Length	Mass (Da)
	Q9I234 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 49C2EC78FF055773	FASTA	213	23,152
	10 20 30 40 50 60 MTSLRYWDIS PALDPNTPTW PGDTPFQQEW AARLDEQCPV NVGRITLSPH TGAHVDGPLH 70 80 90 100 110 120 YRADGLPIGQ VPLDIYMGPC RVIHCIGANP LVTPEHLAGQ LDDLPSRVLL RTFERVPANW 130 140 150 160 170 180 PEGFCAIAPA TIECLAERGV RLVGIDTPSL DPQHSKTLDA HHAVGRHGMA ILEGVVLDDV 190 200 210 PAGDYELLAL PLKFTHLDAS PVRAVLRALP TAE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen." Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. , Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V. Nature 406:959-964(2000) [PubMed: 10984043] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
[2]	"Aerobic tryptophan degradation pathway in bacteria: novel kynurenine formamidase." Kurnasov O., Jablonski L., Polanuyer B., Dorrestein P., Begley T., Osterman A. FEMS Microbiol. Lett. 227:219-227(2003) [PubMed: 14592712] [Abstract] Cited for: FUNCTION, CATALYTIC ACTIVITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004091 Genomic DNA. Translation: AAG05469.1.
PIR	E83386.
RefSeq	NP_250771.1. NC_002516.2.
3D structure databases
ProteinModelPortal	Q9I234.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	878591.
GenomeReviews	Gene locus PA2081 in contig AE004091_GR.
KEGG	pae:PA2081.
NMPDR	fig|208964.1.peg.2081.
PATRIC	19838586. VBIPseAer58763_2173.
Organism-specific databases
PseudoCAP	PA2081.
Phylogenomic databases
HOGENOM	HBG686791.
OMA	FERVPAN.
ProtClustDB	CLSK866998.
Enzyme and pathway databases
BioCyc	PAER208964:PA2081-MONOMER.
Family and domain databases
InterPro	IPR017484. Arylformamidase. IPR007325. Cyclase. [Graphical view]
KO	K07130.
Pfam	PF04199. Cyclase. 1 hit. [Graphical view]
TIGRFAMs	TIGR03035. Trp_arylform. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KYNB_PSEAE

Accession

Primary (citable) accession number: Q9I234

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	March 1, 2001
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program