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Q9I229

- Q9I229_PSEAE

UniProt

Q9I229 - Q9I229_PSEAE

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Protein
Submitted name:

Probable epoxide hydrolase

Gene
PA2086
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141Sulfate 2Imported
Binding sitei14 – 141Sulfate 3Imported
Binding sitei23 – 231Sulfate 2Imported
Binding sitei23 – 231Sulfate 3Imported
Binding sitei48 – 481Sulfate 1Imported
Binding sitei48 – 481Sulfate 5Imported
Binding sitei48 – 481Sulfate 6Imported
Binding sitei52 – 521Sulfate 7Imported
Binding sitei65 – 651Sulfate 4Imported
Binding sitei87 – 871Sulfate 4Imported
Binding sitei111 – 1111Chloride 1Imported
Binding sitei111 – 1111Chloride 2Imported
Binding sitei149 – 1491Sulfate 12Imported
Binding sitei176 – 1761Sulfate 14; via carbonyl oxygenImported
Binding sitei180 – 1801Sulfate 14Imported
Binding sitei198 – 1981Sulfate 15Imported
Binding sitei199 – 1991Sulfate 16Imported
Binding sitei214 – 2141Sulfate 8Imported
Binding sitei226 – 2261Sulfate 17Imported
Binding sitei229 – 2291Sulfate 18Imported
Binding sitei233 – 2331Sulfate 10Imported
Binding sitei274 – 2741Sulfate 11Imported
Binding sitei274 – 2741Sulfate 13Imported
Binding sitei274 – 2741Sulfate 8Imported

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
Probable epoxide hydrolaseImported
Gene namesi
Ordered Locus Names:PA2086Imported
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)Imported
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA2086.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA2086.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4B9AX-ray1.45A1-300[»]
4B9EX-ray1.40A1-300[»]
4BATX-ray1.30A1-300[»]
4BAUX-ray1.55A1-300[»]
4BAZX-ray1.35A1-300[»]
4BB0X-ray1.77A1-300[»]
ProteinModelPortaliQ9I229.
SMRiQ9I229. Positions 4-299.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni107 – 1115Sulfate 8 bindingImported
Regioni120 – 1234Sulfate 9 bindingImported
Regioni152 – 1532Sulfate 13 bindingImported
Regioni152 – 1532Sulfate 8 bindingImported
Regioni234 – 2363Sulfate 19 bindingImported
Regioni244 – 2463Sulfate 11 bindingImported
Regioni260 – 2612Sulfate 18 bindingImported
Regioni281 – 2833Sulfate 21 bindingImported
Regioni295 – 2984Sulfate 20 bindingImported

Phylogenomic databases

HOGENOMiHOG000028073.
KOiK01561.
OMAiTHVIWHK.
OrthoDBiEOG647TWF.
PhylomeDBiQ9I229.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PRINTSiPR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9I229-1 [UniParc]FASTAAdd to Basket

« Hide

MNTDPLLPGF DYLTLHTSAA RLRVAVKGSG PPLLLLHGYP QTHLAWHRIA    50
PRLAEDYSVV LADLRGYGES RALDEEGADY SKAALARDQL ETMGQLGFER 100
FAVIGHDRGA RVGYRLALDH PQAVAAFVSL TVVPILDNWA AVNKVFALNA 150
YHWFLLAQPY DLPERLIGAD PEHFLDYTLR RMAQGRDIYH PQALESYRRA 200
FRDPAVRHAM CEDYRAAVGV DADADQADRD AGRRLQCPVQ VLWQERPYAA 250
GQHPLEIWKT WAGQVEGAAI GASHMLPEDA PDAVLEHLLG FLASHREALR 300
Length:300
Mass (Da):33,485
Last modified:March 1, 2001 - v1
Checksum:i993122FF5635032F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG05474.1.
PIRiH83384.
RefSeqiNP_250776.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG05474; AAG05474; PA2086.
GeneIDi882121.
KEGGipae:PA2086.
PATRICi19838596. VBIPseAer58763_2178.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG05474.1 .
PIRi H83384.
RefSeqi NP_250776.1. NC_002516.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4B9A X-ray 1.45 A 1-300 [» ]
4B9E X-ray 1.40 A 1-300 [» ]
4BAT X-ray 1.30 A 1-300 [» ]
4BAU X-ray 1.55 A 1-300 [» ]
4BAZ X-ray 1.35 A 1-300 [» ]
4BB0 X-ray 1.77 A 1-300 [» ]
ProteinModelPortali Q9I229.
SMRi Q9I229. Positions 4-299.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA2086.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG05474 ; AAG05474 ; PA2086 .
GeneIDi 882121.
KEGGi pae:PA2086.
PATRICi 19838596. VBIPseAer58763_2178.

Organism-specific databases

PseudoCAPi PA2086.

Phylogenomic databases

HOGENOMi HOG000028073.
KOi K01561.
OMAi THVIWHK.
OrthoDBi EOG647TWF.
PhylomeDBi Q9I229.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR000639. Epox_hydrolase-like.
[Graphical view ]
PRINTSi PR00412. EPOXHYDRLASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
  2. "Structure of a Putative Epoxide Hydrolase Mutant."
    Schmidberger J.W., Schnell R., Schneider G.
    Submitted (SEP-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.77 ANGSTROMS).
  3. "Structure of a Putative Epoxide Hydrolase Q244E Mutant from Pseudomonas Aeruginosa."
    Schmidberger J.W., Schnell R., Schneider G.
    Submitted (SEP-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS).
  4. "Structure of a Putative Epoxide Hydrolase T131D Mutant from Pseudomonas Aeruginosa, with Bound Mfa."
    Schmidberger J.W., Schnell R., Schneider G.
    Submitted (SEP-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS).
  5. "Structure of a Putative Epoxide Hydrolase T131D Mutant from Pseudomonas Aeruginosa."
    Schmidberger J.W., Schnell R., Schneider G.
    Submitted (SEP-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS).
  6. "The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery."
    Moynie L., Schnell R., McMahon S.A., Sandalova T., Boulkerou W.A., Schmidberger J.W., Alphey M., Cukier C., Duthie F., Kopec J., Liu H., Jacewicz A., Hunter W.N., Naismith J.H., Schneider G.
    Acta Crystallogr. F 69:25-34(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS).

Entry informationi

Entry nameiQ9I229_PSEAE
AccessioniPrimary (citable) accession number: Q9I229
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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