ID   Q9I1S1_PSEAE            Unreviewed;       194 AA.
AC   Q9I1S1;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   27-MAR-2024, entry version 136.
DE   SubName: Full=Probable transcriptional regulator {ECO:0000313|EMBL:AAG05584.1};
GN   OrderedLocusNames=PA2196 {ECO:0000313|EMBL:AAG05584.1};
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964 {ECO:0000313|EMBL:AAG05584.1, ECO:0000313|Proteomes:UP000002438};
RN   [1] {ECO:0000313|EMBL:AAG05584.1, ECO:0000313|Proteomes:UP000002438}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
RC   1C / PRS 101 / PAO1 {ECO:0000313|Proteomes:UP000002438};
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.Q., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R., Smith K.,
RA   Spencer D., Wong G.K., Wu Z., Paulsen I.T., Reizer J., Saier M.H.,
RA   Hancock R.E., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
RN   [2] {ECO:0007829|PDB:3RD3}
RP   X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS), AND DISULFIDE BONDS.
RA   Choe J., Kang Y.;
RT   "Structure of Pseudomonas aeruginosa transcriptional regulator PA2196.";
RL   Submitted (MAR-2011) to the PDB data bank.
RN   [3] {ECO:0007829|PDB:4L62}
RP   X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 4-193.
RX   PubMed=24070609; DOI=10.1016/j.bbrc.2013.09.074;
RA   Kim Y., Kang Y., Choe J.;
RT   "Crystal structure of Pseudomonas aeruginosa transcriptional regulator
RT   PA2196 bound to its operator DNA.";
RL   Biochem. Biophys. Res. Commun. 440:317-321(2013).
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DR   EMBL; AE004091; AAG05584.1; -; Genomic_DNA.
DR   PIR; A83371; A83371.
DR   RefSeq; NP_250886.1; NC_002516.2.
DR   RefSeq; WP_003113688.1; NZ_QZGE01000014.1.
DR   PDB; 3RD3; X-ray; 2.40 A; A/B=1-194.
DR   PDB; 4L62; X-ray; 2.90 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=4-193.
DR   PDBsum; 3RD3; -.
DR   PDBsum; 4L62; -.
DR   AlphaFoldDB; Q9I1S1; -.
DR   SMR; Q9I1S1; -.
DR   STRING; 208964.PA2196; -.
DR   PaxDb; 208964-PA2196; -.
DR   GeneID; 881967; -.
DR   KEGG; pae:PA2196; -.
DR   PATRIC; fig|208964.12.peg.2300; -.
DR   PseudoCAP; PA2196; -.
DR   HOGENOM; CLU_069356_28_1_6; -.
DR   InParanoid; Q9I1S1; -.
DR   OrthoDB; 4541465at2; -.
DR   PhylomeDB; Q9I1S1; -.
DR   BioCyc; PAER208964:G1FZ6-2236-MONOMER; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:PseudoCAP.
DR   Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR011075; TetR_C.
DR   PANTHER; PTHR47506:SF6; HTH-TYPE TRANSCRIPTIONAL REPRESSOR NEMR; 1.
DR   PANTHER; PTHR47506; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR   Pfam; PF16925; TetR_C_13; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:3RD3, ECO:0007829|PDB:4L62};
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00335};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002438}.
FT   DOMAIN          6..66
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50977"
FT   DNA_BIND        29..48
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
FT   DISULFID        97..100
FT                   /evidence="ECO:0007829|PDB:3RD3"
SQ   SEQUENCE   194 AA;  21747 MW;  41E57F696C5D8303 CRC64;
     MKTSYDDTRQ HLLDTGYRIM AVKGFSGVGL NEILQSAGVP KGSFYHYFKS KEQFGQALLE
     DYFRVYLADM DQRFSAPGLN ARERLMSYWQ KWLDNACPPC DEQRCLVVKL SAEVADLSES
     MRITLRDGSD GIIERLVGCL GQGRDDGSLA PCDARHMASA LYQLWLGASL LSKLHRSPGP
     LETAMQTTRS LLEI
//