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Q9I1Q5

- PDXA2_PSEAE

UniProt

Q9I1Q5 - PDXA2_PSEAE

Protein

4-hydroxythreonine-4-phosphate dehydrogenase 2

Gene

pdxA2

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).UniRule annotation

    Catalytic activityi

    4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

    Cofactori

    Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi173 – 1731Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi217 – 2171Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi274 – 2741Divalent metal cation; shared with dimeric partnerUniRule annotation
    Binding sitei282 – 2821SubstrateUniRule annotation

    GO - Molecular functioni

    1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. cobalt ion binding Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. NAD binding Source: InterPro
    5. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
    2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyridoxine biosynthesis

    Keywords - Ligandi

    Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00244; UER00312.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxythreonine-4-phosphate dehydrogenase 2UniRule annotation (EC:1.1.1.262UniRule annotation)
    Alternative name(s):
    4-(phosphohydroxy)-L-threonine dehydrogenase 2UniRule annotation
    Gene namesi
    Name:pdxA2UniRule annotation
    Ordered Locus Names:PA2212
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA2212.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3373374-hydroxythreonine-4-phosphate dehydrogenase 2PRO_0000188816Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi208964.PA2212.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9I1Q5.
    SMRiQ9I1Q5. Positions 6-331.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PdxA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1995.
    HOGENOMiHOG000221593.
    KOiK00097.
    OMAiWNARVTS.
    OrthoDBiEOG6GN6ZC.
    PhylomeDBiQ9I1Q5.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    HAMAPiMF_00536. PdxA.
    InterProiIPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view]
    PfamiPF04166. PdxA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9I1Q5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNAPSLPRLA MVLGDPAGIG PELIARLLAD TEVREKAHIV LIADEAEMRR    50
    GMRIAGCEFP YRRIDALETL DFADATPLLH PWLSQGGDEF PRSEASAVGG 100
    RYSLETLALA LELTRSGRTD AILFGPLNKT SLHMAGMDHS DELHWFAERL 150
    GFGGPFCEFN VLDDLWTSRV TSHVALAEVP GLLSQERVGE AIRLIDDALR 200
    RSGLARPRIG VCGLNPHNGD NGSFGREELD IIAPAVQKAR EQGIAADGPY 250
    PADTIFLKVQ GDARAFDAVV TMYHDQGQIA IKLMGFSRGV TVQGGLPIPI 300
    ATPAHGTAFD IAGQGRADVG ATRQAFEIAC RMGRHKA 337
    Length:337
    Mass (Da):36,321
    Last modified:March 1, 2001 - v1
    Checksum:i7F53FD3707265B13
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG05600.1.
    PIRiC83370.
    RefSeqiNP_250902.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG05600; AAG05600; PA2212.
    GeneIDi881915.
    KEGGipae:PA2212.
    PATRICi19838872. VBIPseAer58763_2316.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG05600.1 .
    PIRi C83370.
    RefSeqi NP_250902.1. NC_002516.2.

    3D structure databases

    ProteinModelPortali Q9I1Q5.
    SMRi Q9I1Q5. Positions 6-331.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208964.PA2212.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG05600 ; AAG05600 ; PA2212 .
    GeneIDi 881915.
    KEGGi pae:PA2212.
    PATRICi 19838872. VBIPseAer58763_2316.

    Organism-specific databases

    PseudoCAPi PA2212.

    Phylogenomic databases

    eggNOGi COG1995.
    HOGENOMi HOG000221593.
    KOi K00097.
    OMAi WNARVTS.
    OrthoDBi EOG6GN6ZC.
    PhylomeDBi Q9I1Q5.

    Enzyme and pathway databases

    UniPathwayi UPA00244 ; UER00312 .

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    HAMAPi MF_00536. PdxA.
    InterProi IPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view ]
    Pfami PF04166. PdxA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

    Entry informationi

    Entry nameiPDXA2_PSEAE
    AccessioniPrimary (citable) accession number: Q9I1Q5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The active site is located at the dimer interface.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3