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Q9I1Q5 (PDXA2_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
4-hydroxythreonine-4-phosphate dehydrogenase 2

EC=1.1.1.262
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase 2
Gene names
Name:pdxA2
Ordered Locus Names:PA2212
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) [Reference proteome] [HAMAP]
Taxonomic identifier208964 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity. HAMAP-Rule MF_00536

Catalytic activity

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH. HAMAP-Rule MF_00536

Cofactor

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathway

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5. HAMAP-Rule MF_00536

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00536

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00536.

Miscellaneous

The active site is located at the dimer interface By similarity.

Sequence similarities

Belongs to the PdxA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3373374-hydroxythreonine-4-phosphate dehydrogenase 2 HAMAP-Rule MF_00536
PRO_0000188816

Sites

Metal binding1731Divalent metal cation; shared with dimeric partner By similarity
Metal binding2171Divalent metal cation; shared with dimeric partner By similarity
Metal binding2741Divalent metal cation; shared with dimeric partner By similarity
Binding site2821Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9I1Q5 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 7F53FD3707265B13

FASTA33736,321
        10         20         30         40         50         60 
MNAPSLPRLA MVLGDPAGIG PELIARLLAD TEVREKAHIV LIADEAEMRR GMRIAGCEFP 

        70         80         90        100        110        120 
YRRIDALETL DFADATPLLH PWLSQGGDEF PRSEASAVGG RYSLETLALA LELTRSGRTD 

       130        140        150        160        170        180 
AILFGPLNKT SLHMAGMDHS DELHWFAERL GFGGPFCEFN VLDDLWTSRV TSHVALAEVP 

       190        200        210        220        230        240 
GLLSQERVGE AIRLIDDALR RSGLARPRIG VCGLNPHNGD NGSFGREELD IIAPAVQKAR 

       250        260        270        280        290        300 
EQGIAADGPY PADTIFLKVQ GDARAFDAVV TMYHDQGQIA IKLMGFSRGV TVQGGLPIPI 

       310        320        330 
ATPAHGTAFD IAGQGRADVG ATRQAFEIAC RMGRHKA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004091 Genomic DNA. Translation: AAG05600.1.
PIRC83370.
RefSeqNP_250902.1. NC_002516.2.

3D structure databases

ProteinModelPortalQ9I1Q5.
SMRQ9I1Q5. Positions 6-331.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING208964.PA2212.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID881915.
KEGGpae:PA2212.
PATRIC19838872. VBIPseAer58763_2316.

Organism-specific databases

PseudoCAPPA2212.

Phylogenomic databases

eggNOGCOG1995.
HOGENOMHOG000221593.
KOK00097.
OMADQGQIAM.
OrthoDBEOG6GN6ZC.
ProtClustDBPRK00232.

Enzyme and pathway databases

UniPathwayUPA00244; UER00312.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
HAMAPMF_00536. PdxA.
InterProIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamPF04166. PdxA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePDXA2_PSEAE
AccessionPrimary (citable) accession number: Q9I1Q5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: March 1, 2001
Last modified: February 19, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways