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Q9I1M2 (ODBA_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-oxoisovalerate dehydrogenase subunit alpha
EC=1.2.4.4
Alternative name(s):
Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain
Short name=BCKDH E1-alpha
Gene names
Name:bkdA1
Ordered Locus Names:PA2247
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifier208964 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length410 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO2. It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activity

3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2.

Cofactor

Thiamine pyrophosphate By similarity.

Subunit structure

Heterodimer of an alpha and a beta chain By similarity.

Sequence similarities

Belongs to the BCKDHA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4104102-oxoisovalerate dehydrogenase subunit alpha
PRO_0000287782

Sequences

Sequence LengthMass (Da)Tools
Q9I1M2 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: BE3AF6FAB66F0F01

FASTA41045,256
        10         20         30         40         50         60 
MSDYEPLRLH VPEPTGRPGC KTDFSYLHLS PAGEVRKPPV DVEPAETSDL AYSLVRVLDD 

        70         80         90        100        110        120 
DGHAVGPWNP QLSNEQLLRG MRAMLKTRLF DARMLTAQRQ KKLSFYMQCL GEEAIATAHT 

       130        140        150        160        170        180 
LALRDGDMCF PTYRQQGILI TREYPLVDMI CQLLSNEADP LKGRQLPIMY SSKEAGFFSI 

       190        200        210        220        230        240 
SGNLATQFIQ AVGWGMASAI KGDTRIASAW IGDGATAESD FHTALTFAHV YRAPVILNVV 

       250        260        270        280        290        300 
NNQWAISTFQ AIAGGEGTTF ANRGVGCGIA SLRVDGNDFL AVYAASEWAA ERARRNLGPS 

       310        320        330        340        350        360 
LIEWVTYRAG PHSTSDDPSK YRPADDWTNF PLGDPIARLK RHMIGLGIWS EEQHEATHKA 

       370        380        390        400        410 
LEAEVLAAQK QAESHGTLID GRVPSAASMF EDVYAELPEH LRRQRQELGV

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE004091 Genomic DNA. Translation: AAG05635.1.
PIRC83365.
S05057.
RefSeqNP_250937.1. NC_002516.2.

3D structure databases

HSSPHSSP built from PDB template 2BP7 based on UniProtKB P09060.
ProteinModelPortalQ9I1M2.
SMRQ9I1M2. Positions 2-408.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID877901.
GenomeReviewsGene locus PA2247 in contig AE004091_GR.
KEGGpae:PA2247.
PATRIC19838936. VBIPseAer58763_2348.

Organism-specific databases

PseudoCAPPA2247.

Phylogenomic databases

HOGENOMHBG753263.
OMAQGWWDEE.
ProtClustDBCLSK864052.

Enzyme and pathway databases

BioCycPAER208964:PA2247-MONOMER.

Family and domain databases

InterProIPR001017. DH_E1.
IPR022593. Oxoisovalerate_DH_suAlpha_N.
[Graphical view]
KOK00166.
PfamPF00676. E1_dh. 1 hit.
PF12573. OxoDH_E1alpha_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameODBA_PSEAE
AccessionPrimary (citable) accession number: Q9I1M2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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