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Reviewed, UniProtKB/Swiss-Prot Q9I1M1 (ODBB_PSEAE)

Last modified June 16, 2009. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesRecommended name:
    2-oxoisovalerate dehydrogenase subunit beta
    EC=1.2.4.4
Alternative name(s):
    Branched-chain alpha-keto acid dehydrogenase E1 component beta chain
      Short name=BCKDH E1-beta
Gene names
Name: bkdA2
Ordered Locus Names: PA2248
OrganismPseudomonas aeruginosa [Complete proteome] [HAMAP]
Taxonomic identifier287 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

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Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO2. It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activity

3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2.

Cofactor

Thiamine pyrophosphate By similarity.

Subunit structure

Heterodimer of an alpha and a beta chain By similarity.

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Ontologies

Keywords
   LigandThiamine pyrophosphate
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3503502-oxoisovalerate dehydrogenase subunit beta
PRO_0000287783

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Sequences

Sequence LengthMass (Da)Tools
Q9I1M1-1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: D7983A05A9B3EB0A

FASTA35038,325
        10         20         30         40         50         60 
MNAMNPQHEN AQTVTSMTMI QALRSAMDIM LERDDDVVVF GQDVGYFGGV FRCTEGLQKK 

        70         80         90        100        110        120 
YGTSRVFDAP ISESGIIGAA VGMGAYGLRP VVEIQFADYV YPASDQLISE AARLRYRSAG 

       130        140        150        160        170        180 
DFIVPMTVRM PCGGGIYGGQ THSQSPEAMF TQVCGLRTVM PSNPYDAKGL LIACIENDDP 

       190        200        210        220        230        240 
VIFLEPKRLY NGPFDGHHDR PVTPWSKHPA SQVPDGYYKV PLDKAAIVRP GAALTVLTYG 

       250        260        270        280        290        300 
TMVYVAQAAA DETGLDAEII DLRSLWPLDL ETIVASVKKT GRCVIAHEAT RTCGFGAELM 

       310        320        330        340        350 
SLVQEHCFHH LEAPIERVTG WDTPYPHAQE WAYFPGPARV GAAFKRVMEV

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Cross-references

Sequence databases

AE004091 Genomic DNA. Translation: AAG05636.1.
PIRD83365.
S63478.
RefSeqNP_250938.1.

3D structure databases

HSSPHSSP built from PDB template 1QS0 based on UniProtKB P09061.
SMRQ9I1M1. Positions 15-350.
ModBaseSearch...

Genome annotation databases

GeneID879226.
GenomeReviewsGene locus PA2248 in contig AE004091_GR.
KEGGpae:PA2248.

Organism-specific databases

PseudoCAPPA2248.
CMRSearch...

Phylogenomic databases

HOGENOMQ9I1M1.
OMAQ9I1M1. GQAENIW.

Enzyme and pathway databases

BioCycPAER208964:PA2248-MON.
BRENDA1.2.4.4. 354.

Family and domain databases

InterProIPR005476. Transketo_C.
IPR015941. Transketolase_C-like.
IPR005475. Transketolase_central-reg.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
PfamPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameODBB_PSEAE
AccessionPrimary (citable) accession number: Q9I1M1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: June 16, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information