Q9I1C2 (MSUD_PSEAE) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 64.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Methanesulfonate monooxygenase EC=1.14.14.5 Alternative name(s): FMNH2-dependent methanesulfonate monooxygenase Methanesulfonate sulfonatase | ||||
| Gene names |
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| Organism | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) | ||||
| Taxonomic identifier | 208964 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas |
Protein attributes
| Sequence length | 381 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Catalyzes the desulfonation of aliphatic sulfonates. Shows highest activity with methanesulfonate. Ref.1 |
| Catalytic activity | An alkanesufonate (R-CH(2)-SO3H) + FMNH2 + O2 = an aldehyde (R-CHO) + FMN + sulfite + H2O. HAMAP MF_01229 |
| Induction | Repressed by sulfate, cysteine, or thiocyanate. HAMAP MF_01229 |
| Miscellaneous | FMNH2 which is absolutely required for this enzymatic reaction, is provided by MsuE. HAMAP MF_01229 |
| Sequence similarities | Belongs to the SsuD family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | FMN |
| Molecular function | Monooxygenase Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Molecular function | alkanesulfonate monooxygenase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 381 | 381 | Methanesulfonate monooxygenase HAMAP MF_01229 | PRO_0000216710 | |||||
Experimental info | |||||||||
| Sequence conflict | 28 | 1 | P → S in AAB82564. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A novel reduced flavin mononucleotide-dependent methanesulfonate sulfonatase encoded by the sulfur-regulated msu operon of Pseudomonas aeruginosa." Kertesz M.A., Schmidt-Larbig K., Wueest T. J. Bacteriol. 181:1464-1473(1999) [PubMed: 10049377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228. |
| [2] | "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen." Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. Olson M.V.Nature 406:959-964(2000) [PubMed: 10984043] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF026067 Genomic DNA. Translation: AAB82564.1. AE004091 Genomic DNA. Translation: AAG05744.1. |
| PIR | E83352. |
| RefSeq | NP_251046.1. NC_002516.2. |
3D structure databases | |
| ProteinModelPortal | Q9I1C2. |
| SMR | Q9I1C2. Positions 1-347. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 879651. |
| GenomeReviews | Gene locus PA2356 in contig AE004091_GR. |
| KEGG | pae:PA2356. |
| PATRIC | 19839171. VBIPseAer58763_2465. |
Organism-specific databases | |
| PseudoCAP | PA2356. |
Phylogenomic databases | |
| HOGENOM | HBG639644. |
| OMA | YLVAVRP. |
| ProtClustDB | CLSK867201. |
Enzyme and pathway databases | |
| BioCyc | PAER208964:PA2356-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01229. Alkanesulf_monooxygen. [Tree] |
| InterPro | IPR019911. Alkanesulphonate_mOase_FMN-dep. IPR011251. Luciferase-like_dom. [Graphical view] |
| Gene3D | G3DSA:3.20.20.30. Luciferase_like. 2 hits. |
| KO | K04091. |
| Pfam | PF00296. Bac_luciferase. 1 hit. [Graphical view] |
| SUPFAM | SSF51679. Luciferase_like. 1 hit. |
| TIGRFAMs | TIGR03565. Alk_sulf_monoox. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | MSUD_PSEAE | ||||||||
| Accession | Primary (citable) accession number: Q9I1C2 Secondary accession number(s): O31039 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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