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Q9I137 (GCSP1_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating) 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein 1
Glycine decarboxylase 1
Glycine dehydrogenase (aminomethyl-transferring) 1
Gene names
Name:gcvP1
Ordered Locus Names:PA2445
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) [Reference proteome] [HAMAP]
Taxonomic identifier208964 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length959 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 959959Glycine dehydrogenase (decarboxylating) 1 HAMAP-Rule MF_00711
PRO_0000166925

Amino acid modifications

Modified residue7111N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9I137 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: B8AAB1799210285D

FASTA959103,919
        10         20         30         40         50         60 
MTDNLNLGAI DLGTDDEFIA RHIGPRAADT QAMLQRLGYD SLDTLIGNVI PDSIKGSSVL 

        70         80         90        100        110        120 
DLPAGMGEAE ALASLKAIAA RNRALRSFIG QGYYNCHTPA PILRNLLENP AWYTAYTPYQ 

       130        140        150        160        170        180 
PEISQGRLEA LLNFQTLVSD LSGLPIANAS MLDEATAAAE AMTFCKRLSK NRTSQAFFAS 

       190        200        210        220        230        240 
RHCHPQTLDV LRTRAEPLGI EVVVGDESTI EDFSAYFGAL LQYPTCDGEI VDYRELVSRF 

       250        260        270        280        290        300 
HAVDALVAVA ADLLALTLLT PPGEFGADVA IGSAQRFGVP LGFGGPHAAY FATRDAFKRD 

       310        320        330        340        350        360 
MPGRLVGVSI DRHGKPAYRL AMQTREQHIR REKATSNICT AQVLLANIAS MFAVYHGPQG 

       370        380        390        400        410        420 
LLRIARRTHR LTAILAAGLE RLGVAVEQKH FFDTLSLATG ARTAAIHAKA RAAGINLREI 

       430        440        450        460        470        480 
DAGRLGLSLD ETVRQTDVET LWGLLAEEGQ ALPDFAALAA SSGDRLPVEL LRQSAILSHP 

       490        500        510        520        530        540 
IFNRHHSETE LMRYLRKLAD KDLALDRTMI PLGSCTMKLN AASEMIPVTW AEFGNLHPFA 

       550        560        570        580        590        600 
PAEQSEGYRQ LTDELEAMLC SATGYDAVSL QPNAGSQGEY AGLLAIRAYH QSRGDSQRDI 

       610        620        630        640        650        660 
CLIPSSAHGT NPATASMVGM RVVVVACDAR GNVDVEDLRN KASEHKERLA ALMITYPSTH 

       670        680        690        700        710        720 
GVFEEAIREI CAIVHDCGGQ VYIDGANMNA MVGLCAPGKF GGDVSHLNLH KTFCIPHGGG 

       730        740        750        760        770        780 
GPGVGPIGVR AHLAPFLPGH ARGERKEGAV SAAPYGSASI LPITWMYIRM MGGEGLKRAS 

       790        800        810        820        830        840 
EMAILNANYI AHRLEEHYPV LYAGGNGLVA HECILDLRPL KDSSGISVDD VAKRLMDFGF 

       850        860        870        880        890        900 
HAPTMSFPVA GTLMIEPTES ESKAELDRFC DAMIRIREEI RAVERGELDK EDNPLKNAPH 

       910        920        930        940        950 
TAAELLGEWN HAYSREQAAY PLASLVEAKY WPPVGRVDNV YGDRNLTCSC PPIEAYSEE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004091 Genomic DNA. Translation: AAG05833.1.
PIRD83339.
RefSeqNP_251135.1. NC_002516.2.

3D structure databases

ProteinModelPortalQ9I137.
SMRQ9I137. Positions 12-950.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING208964.PA2445.

Proteomic databases

PRIDEQ9I137.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID882927.
KEGGpae:PA2445.
PATRIC19839357. VBIPseAer58763_2558.

Organism-specific databases

PseudoCAPPA2445.

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAIRVQVII.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP1_PSEAE
AccessionPrimary (citable) accession number: Q9I137
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families