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Q9I137

- GCSP1_PSEAE

UniProt

Q9I137 - GCSP1_PSEAE

Protein

Glycine dehydrogenase (decarboxylating) 1

Gene

gcvP1

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.By similarity

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating) 1 (EC:1.4.4.2)
    Alternative name(s):
    Glycine cleavage system P-protein 1
    Glycine decarboxylase 1
    Glycine dehydrogenase (aminomethyl-transferring) 1
    Gene namesi
    Name:gcvP1
    Ordered Locus Names:PA2445
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA2445.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 959959Glycine dehydrogenase (decarboxylating) 1PRO_0000166925Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei711 – 7111N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PRIDEiQ9I137.

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.By similarity

    Protein-protein interaction databases

    STRINGi208964.PA2445.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9I137.
    SMRiQ9I137. Positions 12-950.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.Curated

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiAELMPVS.
    OrthoDBiEOG6HMXDX.
    PhylomeDBiQ9I137.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9I137-1 [UniParc]FASTAAdd to Basket

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    MTDNLNLGAI DLGTDDEFIA RHIGPRAADT QAMLQRLGYD SLDTLIGNVI    50
    PDSIKGSSVL DLPAGMGEAE ALASLKAIAA RNRALRSFIG QGYYNCHTPA 100
    PILRNLLENP AWYTAYTPYQ PEISQGRLEA LLNFQTLVSD LSGLPIANAS 150
    MLDEATAAAE AMTFCKRLSK NRTSQAFFAS RHCHPQTLDV LRTRAEPLGI 200
    EVVVGDESTI EDFSAYFGAL LQYPTCDGEI VDYRELVSRF HAVDALVAVA 250
    ADLLALTLLT PPGEFGADVA IGSAQRFGVP LGFGGPHAAY FATRDAFKRD 300
    MPGRLVGVSI DRHGKPAYRL AMQTREQHIR REKATSNICT AQVLLANIAS 350
    MFAVYHGPQG LLRIARRTHR LTAILAAGLE RLGVAVEQKH FFDTLSLATG 400
    ARTAAIHAKA RAAGINLREI DAGRLGLSLD ETVRQTDVET LWGLLAEEGQ 450
    ALPDFAALAA SSGDRLPVEL LRQSAILSHP IFNRHHSETE LMRYLRKLAD 500
    KDLALDRTMI PLGSCTMKLN AASEMIPVTW AEFGNLHPFA PAEQSEGYRQ 550
    LTDELEAMLC SATGYDAVSL QPNAGSQGEY AGLLAIRAYH QSRGDSQRDI 600
    CLIPSSAHGT NPATASMVGM RVVVVACDAR GNVDVEDLRN KASEHKERLA 650
    ALMITYPSTH GVFEEAIREI CAIVHDCGGQ VYIDGANMNA MVGLCAPGKF 700
    GGDVSHLNLH KTFCIPHGGG GPGVGPIGVR AHLAPFLPGH ARGERKEGAV 750
    SAAPYGSASI LPITWMYIRM MGGEGLKRAS EMAILNANYI AHRLEEHYPV 800
    LYAGGNGLVA HECILDLRPL KDSSGISVDD VAKRLMDFGF HAPTMSFPVA 850
    GTLMIEPTES ESKAELDRFC DAMIRIREEI RAVERGELDK EDNPLKNAPH 900
    TAAELLGEWN HAYSREQAAY PLASLVEAKY WPPVGRVDNV YGDRNLTCSC 950
    PPIEAYSEE 959
    Length:959
    Mass (Da):103,919
    Last modified:March 1, 2001 - v1
    Checksum:iB8AAB1799210285D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG05833.1.
    PIRiD83339.
    RefSeqiNP_251135.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG05833; AAG05833; PA2445.
    GeneIDi882927.
    KEGGipae:PA2445.
    PATRICi19839357. VBIPseAer58763_2558.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG05833.1 .
    PIRi D83339.
    RefSeqi NP_251135.1. NC_002516.2.

    3D structure databases

    ProteinModelPortali Q9I137.
    SMRi Q9I137. Positions 12-950.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208964.PA2445.

    Proteomic databases

    PRIDEi Q9I137.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG05833 ; AAG05833 ; PA2445 .
    GeneIDi 882927.
    KEGGi pae:PA2445.
    PATRICi 19839357. VBIPseAer58763_2558.

    Organism-specific databases

    PseudoCAPi PA2445.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi AELMPVS.
    OrthoDBi EOG6HMXDX.
    PhylomeDBi Q9I137.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

    Entry informationi

    Entry nameiGCSP1_PSEAE
    AccessioniPrimary (citable) accession number: Q9I137
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3