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Q9I137

- GCSP1_PSEAE

UniProt

Q9I137 - GCSP1_PSEAE

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Protein

Glycine dehydrogenase (decarboxylating) 1

Gene

gcvP1

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity).By similarity

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.

Cofactori

Pyridoxal phosphate.By similarity

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein 1
Glycine decarboxylase 1
Glycine dehydrogenase (aminomethyl-transferring) 1
Gene namesi
Name:gcvP1
Ordered Locus Names:PA2445
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA2445.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 959959Glycine dehydrogenase (decarboxylating) 1PRO_0000166925Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei711 – 7111N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PRIDEiQ9I137.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.By similarity

Protein-protein interaction databases

STRINGi208964.PA2445.

Structurei

3D structure databases

ProteinModelPortaliQ9I137.
SMRiQ9I137. Positions 12-950.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.Curated

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
InParanoidiQ9I137.
KOiK00281.
OMAiAELMPVS.
OrthoDBiEOG6HMXDX.
PhylomeDBiQ9I137.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9I137 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MTDNLNLGAI DLGTDDEFIA RHIGPRAADT QAMLQRLGYD SLDTLIGNVI
60 70 80 90 100
PDSIKGSSVL DLPAGMGEAE ALASLKAIAA RNRALRSFIG QGYYNCHTPA
110 120 130 140 150
PILRNLLENP AWYTAYTPYQ PEISQGRLEA LLNFQTLVSD LSGLPIANAS
160 170 180 190 200
MLDEATAAAE AMTFCKRLSK NRTSQAFFAS RHCHPQTLDV LRTRAEPLGI
210 220 230 240 250
EVVVGDESTI EDFSAYFGAL LQYPTCDGEI VDYRELVSRF HAVDALVAVA
260 270 280 290 300
ADLLALTLLT PPGEFGADVA IGSAQRFGVP LGFGGPHAAY FATRDAFKRD
310 320 330 340 350
MPGRLVGVSI DRHGKPAYRL AMQTREQHIR REKATSNICT AQVLLANIAS
360 370 380 390 400
MFAVYHGPQG LLRIARRTHR LTAILAAGLE RLGVAVEQKH FFDTLSLATG
410 420 430 440 450
ARTAAIHAKA RAAGINLREI DAGRLGLSLD ETVRQTDVET LWGLLAEEGQ
460 470 480 490 500
ALPDFAALAA SSGDRLPVEL LRQSAILSHP IFNRHHSETE LMRYLRKLAD
510 520 530 540 550
KDLALDRTMI PLGSCTMKLN AASEMIPVTW AEFGNLHPFA PAEQSEGYRQ
560 570 580 590 600
LTDELEAMLC SATGYDAVSL QPNAGSQGEY AGLLAIRAYH QSRGDSQRDI
610 620 630 640 650
CLIPSSAHGT NPATASMVGM RVVVVACDAR GNVDVEDLRN KASEHKERLA
660 670 680 690 700
ALMITYPSTH GVFEEAIREI CAIVHDCGGQ VYIDGANMNA MVGLCAPGKF
710 720 730 740 750
GGDVSHLNLH KTFCIPHGGG GPGVGPIGVR AHLAPFLPGH ARGERKEGAV
760 770 780 790 800
SAAPYGSASI LPITWMYIRM MGGEGLKRAS EMAILNANYI AHRLEEHYPV
810 820 830 840 850
LYAGGNGLVA HECILDLRPL KDSSGISVDD VAKRLMDFGF HAPTMSFPVA
860 870 880 890 900
GTLMIEPTES ESKAELDRFC DAMIRIREEI RAVERGELDK EDNPLKNAPH
910 920 930 940 950
TAAELLGEWN HAYSREQAAY PLASLVEAKY WPPVGRVDNV YGDRNLTCSC

PPIEAYSEE
Length:959
Mass (Da):103,919
Last modified:March 1, 2001 - v1
Checksum:iB8AAB1799210285D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG05833.1.
PIRiD83339.
RefSeqiNP_251135.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG05833; AAG05833; PA2445.
GeneIDi882927.
KEGGipae:PA2445.
PATRICi19839357. VBIPseAer58763_2558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG05833.1 .
PIRi D83339.
RefSeqi NP_251135.1. NC_002516.2.

3D structure databases

ProteinModelPortali Q9I137.
SMRi Q9I137. Positions 12-950.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA2445.

Proteomic databases

PRIDEi Q9I137.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG05833 ; AAG05833 ; PA2445 .
GeneIDi 882927.
KEGGi pae:PA2445.
PATRICi 19839357. VBIPseAer58763_2558.

Organism-specific databases

PseudoCAPi PA2445.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
InParanoidi Q9I137.
KOi K00281.
OMAi AELMPVS.
OrthoDBi EOG6HMXDX.
PhylomeDBi Q9I137.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiGCSP1_PSEAE
AccessioniPrimary (citable) accession number: Q9I137
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3