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Q9I104 (DSBD2_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thiol:disulfide interchange protein DsbD 2
EC=1.8.1.8
Alternative name(s):
Protein-disulfide reductase 2
Short name=Disulfide reductase 2
Gene names
Name:dsbD2
Ordered Locus Names:PA2478
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifier208964 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length587 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the formation of correct disulfide bonds in some periplasmic proteins and in the assembly of the periplasmic C-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps By similarity. HAMAP MF_00399

Catalytic activity

Protein dithiol + NAD(P)+ = protein disulfide + NAD(P)H. HAMAP MF_00399

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00399.

Sequence similarities

Belongs to the thioredoxin family. DsbD subfamily.

Contains 1 thioredoxin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 587569Thiol:disulfide interchange protein DsbD 2 HAMAP MF_00399
PRO_0000007382

Regions

Topological domain19 – 172154Periplasmic Potential
Transmembrane173 – 19321Helical; Potential
Topological domain194 – 21623Cytoplasmic Potential
Transmembrane217 – 23721Helical; Potential
Topological domain238 – 2469Periplasmic Potential
Transmembrane247 – 26721Helical; Potential
Topological domain268 – 29932Cytoplasmic Potential
Transmembrane300 – 32021Helical; Potential
Topological domain321 – 33010Periplasmic Potential
Transmembrane331 – 35121Helical; Potential
Topological domain352 – 3609Cytoplasmic Potential
Transmembrane361 – 38121Helical; Potential
Topological domain382 – 3832Periplasmic Potential
Transmembrane384 – 40421Helical; Potential
Topological domain405 – 41612Cytoplasmic Potential
Transmembrane417 – 43721Helical; Potential
Topological domain438 – 587150Periplasmic Potential
Domain448 – 585138Thioredoxin

Amino acid modifications

Disulfide bond124 ↔ 130Redox-active By similarity
Disulfide bond188 ↔ 308Redox-active By similarity
Disulfide bond500 ↔ 503Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9I104 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: D6627ECCACC13EC4

FASTA58762,093
        10         20         30         40         50         60 
MRVLILLLML LLPGLSQAQP GDDLFAPRGA TQTDFLPVEK AFRFTWERLD DGQVQLRWQI 

        70         80         90        100        110        120 
APGYYLYQKR LRFDGLDPAL QPQLPPGESH SDEFFGESQV YRQSLELTLP AAAAGQLRLG 

       130        140        150        160        170        180 
WQGCADAGLC YPPQSQALDL GGTGPAAAGT SGEVAEDQGL AGSLQAGNLA WSLLLFFGLG 

       190        200        210        220        230        240 
LLLAFAPCSL PMLPILAGLV VGSGAGPRRG LLLAGSYVLS MALVYAGLGV VAALLGGNLQ 

       250        260        270        280        290        300 
AWLQQPWLLG SFAALFVFLA LPMFGFFELQ LPAALRDRLD GLSRGRKGGS LAGAAALGAL 

       310        320        330        340        350        360 
SGLLVGPCMT APLAGALLYI AQTGNALHGG LVLFSLGLGI GMPLLLLVTV GSRFLPKPGP 

       370        380        390        400        410        420 
WMNLVKGVFG FLFLGTAWIL LRPLLGEALW IGLGGALLLV LAYAALHTAR GLARHAVLFG 

       430        440        450        460        470        480 
AAGCIFGLWG AAMLLGAAAG ADDPWRPLQV YAAANRGATP TASAHEAFLT VSQPAELDRQ 

       490        500        510        520        530        540 
LAAAKAEGQW VLLDYYADWC VSCRIMEKQV FAKPDVLAAL QGVRLLRLDV TADNAASREL 

       550        560        570        580 
LHRYQVPGPP SLIWIGPEGE ERRARRLTGE VDAGGFLAHW QATRERG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE004091 Genomic DNA. Translation: AAG05866.1.
PIRF83336.
RefSeqNP_251168.1. NC_002516.2.

3D structure databases

ProteinModelPortalQ9I104.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID882175.
GenomeReviewsGene locus PA2478 in contig AE004091_GR.
KEGGpae:PA2478.
NMPDRfig|208964.1.peg.2478.
PATRIC19839419. VBIPseAer58763_2589.

Organism-specific databases

PseudoCAPPA2478.

Phylogenomic databases

HOGENOMHBG640883.
OMARYQVPGP.
ProtClustDBCLSK867296.

Enzyme and pathway databases

BioCycPAER208964:PA2478-MONOMER.

Family and domain databases

HAMAPMF_00399. DbsD.
[Tree]
InterProIPR003834. Cyt_c_assmbl_TM_dom.
IPR022910. Thiol_diS_interchange_DbsD.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KOK04084.
PfamPF02683. DsbD. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMSSF52833. Thiordxn-like_fd. 1 hit.
PROSITEPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDSBD2_PSEAE
AccessionPrimary (citable) accession number: Q9I104
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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