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Protein

Leucyl/phenylalanyl-tRNA--protein transferase

Gene

aat

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.UniRule annotation

Catalytic activityi

L-leucyl-tRNA(Leu) + [protein] = tRNA(Leu) + L-leucyl-[protein].UniRule annotation
L-phenylalanyl-tRNA(Phe) + [protein] = tRNA + L-phenylalanyl-[protein].UniRule annotation

GO - Molecular functioni

  1. leucyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Leucyl/phenylalanyl-tRNA--protein transferaseUniRule annotation (EC:2.3.2.6UniRule annotation)
Alternative name(s):
L/F-transferaseUniRule annotation
LeucyltransferaseUniRule annotation
PhenyalanyltransferaseUniRule annotation
Gene namesi
Name:aatUniRule annotation
Ordered Locus Names:PA2617
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA2617.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226Leucyl/phenylalanyl-tRNA--protein transferasePRO_0000207234Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi208964.PA2617.

Structurei

3D structure databases

ProteinModelPortaliQ9I0M1.
SMRiQ9I0M1. Positions 2-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L/F-transferase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2360.
HOGENOMiHOG000102325.
InParanoidiQ9I0M1.
KOiK00684.
OMAiYRQGIFP.
OrthoDBiEOG6WX4R3.
PhylomeDBiQ9I0M1.

Family and domain databases

HAMAPiMF_00688. Leu_Phe_trans.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR004616. Leu/Phe-tRNA_Trfase.
[Graphical view]
PfamiPF03588. Leu_Phe_trans. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR00667. aat. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9I0M1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTWLSRTDF DFPPLDKALQ EPNGLLAAGG DLNPQRLVAA YRHGCFPWYQ
60 70 80 90 100
DGQPILWWSP DPRTVLFPDE LHVSRSLAKC LRQQRFEVTF NRDFRAVIQA
110 120 130 140 150
CAAPRNYADG TWITTPMQLA YQELHLRGIA HSVEVWQERQ LVGGLYGLAM
160 170 180 190 200
GRLFFGESMF SRADNASKVG FVTLVRHLRD AGFVLIDCQM PTRHLHSLGA
210 220
RAISRGEFAD YLQRYRDQPP TGDLDF
Length:226
Mass (Da):25,826
Last modified:March 1, 2001 - v1
Checksum:i04736F579000C2A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG06005.1.
PIRiG83318.
RefSeqiNP_251307.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG06005; AAG06005; PA2617.
GeneIDi882323.
KEGGipae:PA2617.
PATRICi19839727. VBIPseAer58763_2739.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG06005.1.
PIRiG83318.
RefSeqiNP_251307.1. NC_002516.2.

3D structure databases

ProteinModelPortaliQ9I0M1.
SMRiQ9I0M1. Positions 2-216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA2617.

Protocols and materials databases

DNASUi882323.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG06005; AAG06005; PA2617.
GeneIDi882323.
KEGGipae:PA2617.
PATRICi19839727. VBIPseAer58763_2739.

Organism-specific databases

PseudoCAPiPA2617.

Phylogenomic databases

eggNOGiCOG2360.
HOGENOMiHOG000102325.
InParanoidiQ9I0M1.
KOiK00684.
OMAiYRQGIFP.
OrthoDBiEOG6WX4R3.
PhylomeDBiQ9I0M1.

Family and domain databases

HAMAPiMF_00688. Leu_Phe_trans.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR004616. Leu/Phe-tRNA_Trfase.
[Graphical view]
PfamiPF03588. Leu_Phe_trans. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR00667. aat. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiLFTR_PSEAE
AccessioniPrimary (citable) accession number: Q9I0M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: March 1, 2001
Last modified: February 4, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.