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Q9I0K4

- ACEA_PSEAE

UniProt

Q9I0K4 - ACEA_PSEAE

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Protein

Isocitrate lyase

Gene

PA2634

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase-positive serine pathway By similarity.By similarity

Catalytic activityi

Isocitrate = succinate + glyoxylate.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei222 – 2221By similarity

GO - Molecular functioni

  1. isocitrate lyase activity Source: PseudoCAP

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. negative regulation of single-species biofilm formation on inanimate substrate Source: PseudoCAP
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

BRENDAi4.1.3.1. 5087.
UniPathwayiUPA00703; UER00719.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate lyase (EC:4.1.3.1)
Short name:
ICL
Short name:
Isocitrase
Short name:
Isocitratase
Gene namesi
Ordered Locus Names:PA2634
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA2634.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 531531Isocitrate lyasePRO_0000068780Add
BLAST

Proteomic databases

PRIDEiQ9I0K4.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA2634.

Structurei

3D structure databases

ProteinModelPortaliQ9I0K4.
SMRiQ9I0K4. Positions 79-506.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2224.
HOGENOMiHOG000191811.
InParanoidiQ9I0K4.
KOiK01637.
OMAiVDEIAGM.
OrthoDBiEOG689HMX.
PhylomeDBiQ9I0K4.

Family and domain databases

Gene3Di3.20.20.60. 3 hits.
InterProiIPR006254. Isocitrate_lyase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamiPF00463. ICL. 3 hits.
[Graphical view]
PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMiSSF51621. SSF51621. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9I0K4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAYQNEIKA VAALKEKNGS SWSAINPEYA ARMRIQNRFK TGLDIAKYTA
60 70 80 90 100
AIMRKDMAEY DADSSVYTQS LGCWHGFIGQ QKLISIKKHL KTTNKRYLYL
110 120 130 140 150
SGWMVAALRS DFGPLPDQSM HEKTAVSGLI EELYTFLRQA DARELDLLFT
160 170 180 190 200
GLDAARAAGD KAKEAELLAQ IDNFETHVVP IIADIDAGFG NAEATYLLAK
210 220 230 240 250
KMIEAGACCI QIENQVSDEK QCGHQDGKVT VPHIDFLAKI NAVRYAFLEL
260 270 280 290 300
GVDDGVIVAR TDSLGAGLTK QIAVTNEPGD LGDLYNSFLD CEEISESELG
310 320 330 340 350
NGDVVIKREG KLLRPKRLAS NLFQFRKGTG EDRCVLDCIT SLQNGADLLW
360 370 380 390 400
IETEKPHVGQ IKAMVDRIRE VIPNAKLVYN NSPSFNWTLN FRQQVFDAFV
410 420 430 440 450
AEGKDVSAYD RNKLMSVEYD DTELAKVADE KIRTFQRDGS AHAGIFHHLI
460 470 480 490 500
TLPTYHTAAL STDNLAKGYF ADEGMLAYVK GVQRQELRQG IACVKHQNMA
510 520 530
GSDIGDNHKE YFAGEAALKA SGKDNTMNQF H
Length:531
Mass (Da):58,887
Last modified:March 1, 2001 - v1
Checksum:iF45A4ECDA3F220CA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG06022.1.
PIRiG83315.
RefSeqiNP_251324.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG06022; AAG06022; PA2634.
GeneIDi882341.
KEGGipae:PA2634.
PATRICi19839761. VBIPseAer58763_2756.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG06022.1 .
PIRi G83315.
RefSeqi NP_251324.1. NC_002516.2.

3D structure databases

ProteinModelPortali Q9I0K4.
SMRi Q9I0K4. Positions 79-506.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA2634.

Proteomic databases

PRIDEi Q9I0K4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG06022 ; AAG06022 ; PA2634 .
GeneIDi 882341.
KEGGi pae:PA2634.
PATRICi 19839761. VBIPseAer58763_2756.

Organism-specific databases

PseudoCAPi PA2634.

Phylogenomic databases

eggNOGi COG2224.
HOGENOMi HOG000191811.
InParanoidi Q9I0K4.
KOi K01637.
OMAi VDEIAGM.
OrthoDBi EOG689HMX.
PhylomeDBi Q9I0K4.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00719 .
BRENDAi 4.1.3.1. 5087.

Family and domain databases

Gene3Di 3.20.20.60. 3 hits.
InterProi IPR006254. Isocitrate_lyase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
Pfami PF00463. ICL. 3 hits.
[Graphical view ]
PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
SUPFAMi SSF51621. SSF51621. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
  2. "Biofouling in water treatment systems: effect of membrane properties on biofilm formation."
    Liddor M.
    Thesis (2005), Ben-Gurion University, Israel
    Cited for: PROTEIN SEQUENCE OF 110-138; 144-156; 245-260; 318-325; 393-404; 414-426 AND 468-480.
    Strain: ATCC 33467 / type 1 smooth.

Entry informationi

Entry nameiACEA_PSEAE
AccessioniPrimary (citable) accession number: Q9I0K4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3