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Q9I0K4

- ACEA_PSEAE

UniProt

Q9I0K4 - ACEA_PSEAE

Protein

Isocitrate lyase

Gene

PA2634

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase-positive serine pathway By similarity.By similarity

    Catalytic activityi

    Isocitrate = succinate + glyoxylate.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei222 – 2221By similarity

    GO - Molecular functioni

    1. isocitrate lyase activity Source: PseudoCAP

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-UniPathway
    2. negative regulation of single-species biofilm formation on inanimate substrate Source: PseudoCAP
    3. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Enzyme and pathway databases

    BRENDAi4.1.3.1. 5087.
    UniPathwayiUPA00703; UER00719.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate lyase (EC:4.1.3.1)
    Short name:
    ICL
    Short name:
    Isocitrase
    Short name:
    Isocitratase
    Gene namesi
    Ordered Locus Names:PA2634
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA2634.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 531531Isocitrate lyasePRO_0000068780Add
    BLAST

    Proteomic databases

    PRIDEiQ9I0K4.

    Interactioni

    Protein-protein interaction databases

    STRINGi208964.PA2634.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9I0K4.
    SMRiQ9I0K4. Positions 79-506.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2224.
    HOGENOMiHOG000191811.
    KOiK01637.
    OMAiVDEIAGM.
    OrthoDBiEOG689HMX.
    PhylomeDBiQ9I0K4.

    Family and domain databases

    Gene3Di3.20.20.60. 3 hits.
    InterProiIPR006254. Isocitrate_lyase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
    PfamiPF00463. ICL. 3 hits.
    [Graphical view]
    PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
    SUPFAMiSSF51621. SSF51621. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q9I0K4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAYQNEIKA VAALKEKNGS SWSAINPEYA ARMRIQNRFK TGLDIAKYTA    50
    AIMRKDMAEY DADSSVYTQS LGCWHGFIGQ QKLISIKKHL KTTNKRYLYL 100
    SGWMVAALRS DFGPLPDQSM HEKTAVSGLI EELYTFLRQA DARELDLLFT 150
    GLDAARAAGD KAKEAELLAQ IDNFETHVVP IIADIDAGFG NAEATYLLAK 200
    KMIEAGACCI QIENQVSDEK QCGHQDGKVT VPHIDFLAKI NAVRYAFLEL 250
    GVDDGVIVAR TDSLGAGLTK QIAVTNEPGD LGDLYNSFLD CEEISESELG 300
    NGDVVIKREG KLLRPKRLAS NLFQFRKGTG EDRCVLDCIT SLQNGADLLW 350
    IETEKPHVGQ IKAMVDRIRE VIPNAKLVYN NSPSFNWTLN FRQQVFDAFV 400
    AEGKDVSAYD RNKLMSVEYD DTELAKVADE KIRTFQRDGS AHAGIFHHLI 450
    TLPTYHTAAL STDNLAKGYF ADEGMLAYVK GVQRQELRQG IACVKHQNMA 500
    GSDIGDNHKE YFAGEAALKA SGKDNTMNQF H 531
    Length:531
    Mass (Da):58,887
    Last modified:March 1, 2001 - v1
    Checksum:iF45A4ECDA3F220CA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG06022.1.
    PIRiG83315.
    RefSeqiNP_251324.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG06022; AAG06022; PA2634.
    GeneIDi882341.
    KEGGipae:PA2634.
    PATRICi19839761. VBIPseAer58763_2756.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004091 Genomic DNA. Translation: AAG06022.1 .
    PIRi G83315.
    RefSeqi NP_251324.1. NC_002516.2.

    3D structure databases

    ProteinModelPortali Q9I0K4.
    SMRi Q9I0K4. Positions 79-506.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208964.PA2634.

    Proteomic databases

    PRIDEi Q9I0K4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG06022 ; AAG06022 ; PA2634 .
    GeneIDi 882341.
    KEGGi pae:PA2634.
    PATRICi 19839761. VBIPseAer58763_2756.

    Organism-specific databases

    PseudoCAPi PA2634.

    Phylogenomic databases

    eggNOGi COG2224.
    HOGENOMi HOG000191811.
    KOi K01637.
    OMAi VDEIAGM.
    OrthoDBi EOG689HMX.
    PhylomeDBi Q9I0K4.

    Enzyme and pathway databases

    UniPathwayi UPA00703 ; UER00719 .
    BRENDAi 4.1.3.1. 5087.

    Family and domain databases

    Gene3Di 3.20.20.60. 3 hits.
    InterProi IPR006254. Isocitrate_lyase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
    Pfami PF00463. ICL. 3 hits.
    [Graphical view ]
    PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
    SUPFAMi SSF51621. SSF51621. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
    2. "Biofouling in water treatment systems: effect of membrane properties on biofilm formation."
      Liddor M.
      Thesis (2005), Ben-Gurion University, Israel
      Cited for: PROTEIN SEQUENCE OF 110-138; 144-156; 245-260; 318-325; 393-404; 414-426 AND 468-480.
      Strain: ATCC 33467 / type 1 smooth.

    Entry informationi

    Entry nameiACEA_PSEAE
    AccessioniPrimary (citable) accession number: Q9I0K4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3