UniProtKB - Q9I0K4 (ACEA_PSEAE)
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Protein
Isocitrate lyase
Gene
PA2634
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Functioni
Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates.By similarity
Catalytic activityi
Isocitrate = succinate + glyoxylate.By similarity
Cofactori
Mg2+By similarity
: glyoxylate cycle Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes (S)-malate from isocitrate.By similarityProteins known to be involved in the 2 steps of the subpathway in this organism are:
- Isocitrate lyase (PA2634)
- Malate synthase G (glcB)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-malate from isocitrate, the pathway glyoxylate cycle and in Carbohydrate metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 184 | MagnesiumBy similarity | 1 | |
Active sitei | 222 | Proton acceptorBy similarity | 1 | |
Binding sitei | 451 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- isocitrate lyase activity Source: PseudoCAP
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- glyoxylate cycle Source: UniProtKB-UniPathway
- negative regulation of single-species biofilm formation on inanimate substrate Source: PseudoCAP
- pathogenesis Source: PseudoCAP
- tricarboxylic acid cycle Source: UniProtKB-KW
Keywordsi
Molecular function | Lyase |
Biological process | Glyoxylate bypass, Tricarboxylic acid cycle |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
BioCyci | PAER208964:G1FZ6-2674-MONOMER |
BRENDAi | 4.1.3.1 5087 |
UniPathwayi | UPA00703; UER00719 |
Names & Taxonomyi
Protein namesi | Recommended name: Isocitrate lyaseBy similarity (EC:4.1.3.1By similarity)Short name: ICLBy similarity Alternative name(s): IsocitraseBy similarity IsocitrataseBy similarity |
Gene namesi | Ordered Locus Names:PA2634 |
Organismi | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Taxonomic identifieri | 208964 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › |
Proteomesi |
|
Organism-specific databases
PseudoCAPi | PA2634 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068780 | 1 – 531 | Isocitrate lyaseAdd BLAST | 531 |
Proteomic databases
PaxDbi | Q9I0K4 |
PRIDEi | Q9I0K4 |
Interactioni
Subunit structurei
Homotetramer.By similarity
Protein-protein interaction databases
STRINGi | 208964.PA2634 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 101 – 103 | Substrate bindingBy similarity | 3 | |
Regioni | 223 – 224 | Substrate bindingBy similarity | 2 | |
Regioni | 380 – 384 | Substrate bindingBy similarity | 5 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG4107RET Bacteria COG2224 LUCA |
HOGENOMi | HOG000191811 |
InParanoidi | Q9I0K4 |
KOi | K01637 |
OMAi | MHDRKQW |
PhylomeDBi | Q9I0K4 |
Family and domain databases
InterProi | View protein in InterPro IPR006254 Isocitrate_lyase IPR015813 Pyrv/PenolPyrv_Kinase-like_dom |
PANTHERi | PTHR21631 PTHR21631, 1 hit |
Pfami | View protein in Pfam PF00463 ICL, 3 hits |
PIRSFi | PIRSF001362 Isocit_lyase, 1 hit |
SUPFAMi | SSF51621 SSF51621, 2 hits |
i Sequence
Sequence statusi: Complete.
Q9I0K4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAYQNEIKA VAALKEKNGS SWSAINPEYA ARMRIQNRFK TGLDIAKYTA
60 70 80 90 100
AIMRKDMAEY DADSSVYTQS LGCWHGFIGQ QKLISIKKHL KTTNKRYLYL
110 120 130 140 150
SGWMVAALRS DFGPLPDQSM HEKTAVSGLI EELYTFLRQA DARELDLLFT
160 170 180 190 200
GLDAARAAGD KAKEAELLAQ IDNFETHVVP IIADIDAGFG NAEATYLLAK
210 220 230 240 250
KMIEAGACCI QIENQVSDEK QCGHQDGKVT VPHIDFLAKI NAVRYAFLEL
260 270 280 290 300
GVDDGVIVAR TDSLGAGLTK QIAVTNEPGD LGDLYNSFLD CEEISESELG
310 320 330 340 350
NGDVVIKREG KLLRPKRLAS NLFQFRKGTG EDRCVLDCIT SLQNGADLLW
360 370 380 390 400
IETEKPHVGQ IKAMVDRIRE VIPNAKLVYN NSPSFNWTLN FRQQVFDAFV
410 420 430 440 450
AEGKDVSAYD RNKLMSVEYD DTELAKVADE KIRTFQRDGS AHAGIFHHLI
460 470 480 490 500
TLPTYHTAAL STDNLAKGYF ADEGMLAYVK GVQRQELRQG IACVKHQNMA
510 520 530
GSDIGDNHKE YFAGEAALKA SGKDNTMNQF H
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE004091 Genomic DNA Translation: AAG06022.1 |
PIRi | G83315 |
RefSeqi | NP_251324.1, NC_002516.2 WP_003113373.1, NC_002516.2 |
Genome annotation databases
EnsemblBacteriai | AAG06022; AAG06022; PA2634 |
GeneIDi | 882341 |
KEGGi | pae:PA2634 |
PATRICi | fig|208964.12.peg.2756 |
Similar proteinsi
Entry informationi
Entry namei | ACEA_PSEAE | |
Accessioni | Q9I0K4Primary (citable) accession number: Q9I0K4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2005 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 28, 2018 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |