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Q9I0J6 (NUOG_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit G

EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit G
NDH-1 subunit G
Gene names
Name:nuoG
Ordered Locus Names:PA2642
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifier208964 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length905 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.

Catalytic activity

NADH + quinone = NAD+ + quinol.

Cofactor

Binds 1 2Fe-2S cluster per subunit By similarity.

Binds 3 4Fe-4S clusters per subunit By similarity.

Subunit structure

Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex.

Sequence similarities

Belongs to the complex I 75 kDa subunit family.

Contains 1 2Fe-2S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 905905NADH-quinone oxidoreductase subunit G
PRO_0000118549

Regions

Domain1 – 83832Fe-2S ferredoxin-type

Sites

Metal binding341Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding451Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding481Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding671Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding991Iron-sulfur 2 (4Fe-4S); via pros nitrogen By similarity
Metal binding1031Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1061Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1121Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1511Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1541Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1571Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding2011Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding2281Iron-sulfur 4 (4Fe-4S) Potential
Metal binding2311Iron-sulfur 4 (4Fe-4S) Potential
Metal binding2351Iron-sulfur 4 (4Fe-4S) Potential
Metal binding2631Iron-sulfur 4 (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9I0J6 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 775E4CD402A8F311

FASTA90599,000
        10         20         30         40         50         60 
MATIHVDGKT LEVDGADNLL QACLSLGLDI PYFCWHPALG SVGACRQCAV KQYTDENDKR 

        70         80         90        100        110        120 
GRLVMSCMTP ATDNTWISIE DEEAKQFRAS VVEWLMTNHP HDCPVCEEGG HCHLQDMTVM 

       130        140        150        160        170        180 
TGHNERRYRF TKRTHQNQEL GPFIAHEMNR CIACYRCVRY YKDYAGGTDL GVYGAHDNVY 

       190        200        210        220        230        240 
FGRVEDGVLE SEFSGNLTEV CPTGVFTDKT HSERYNRKWD MQFAPSICHG CSSGCNISPG 

       250        260        270        280        290        300 
ERYGEIRRIE NRYNGSVNHY FLCDRGRFGY GYVNREDRPR QPLLVLSKQK LSLDGALDQA 

       310        320        330        340        350        360 
AALLKERKVV GIGSPRASLE SNFALRELVG EGNFYSGINE GELDRLRLIL QVMQEGPLPV 

       370        380        390        400        410        420 
PSIRDIEDHD AVFVLGEDLT QTAARIALAL RQSVKGKAVE MAADMKVQPW LDAAVKNIAQ 

       430        440        450        460        470        480 
HAQNPLFIAS VSATRLDDVA EETVHAAPDD LARLGFAVAH AIDPSAPSVA DLDPQAQAFA 

       490        500        510        520        530        540 
QRITDALLAA KRPLVVSGNS LGNKALIEAA ANIAKALKQR EKNGSISLVV GEANSLGLAL 

       550        560        570        580        590        600 
FGGDSVEAAL ERLTSGQADA VVVLENDLYR RTDAARVDAA LAAAKVVIVA DHQQTATTAK 

       610        620        630        640        650        660 
AHLVLPAASF AEGDGTLVSQ EGRAQRFFQV FDPTYYDARN MVREGWRWLH AIHSTLQGKR 

       670        680        690        700        710        720 
VDWTQLDHVT EAVAEAKPIL AGIRDAAPAA SFRIKGLKLA REPHRYSGRT AMRANISVHE 

       730        740        750        760        770        780 
PRTPQDIDSA FAFSMEGYSG SQEDRQQIPF AWSPGWNSPQ AWNKFQDEVG GHLRAGDPGV 

       790        800        810        820        830        840 
RLIEPKGEGL DWFQAVPVPF SAKADSWKVV PLYHLFGSEE NSSRAAPIQQ RIPETYVALS 

       850        860        870        880        890        900 
KEDADRLGVN DGATLGFQLK GQALRLPLRI DEQLGAGLIG LPVGFAGIPA AIAGCSVEGL 


QEAAQ 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004091 Genomic DNA. Translation: AAG06030.1.
PIRG83314.
RefSeqNP_251332.1. NC_002516.2.

3D structure databases

ProteinModelPortalQ9I0J6.
ModBaseSearch...

Proteomic databases

PRIDEQ9I0J6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID882349.
GenomeReviewsGene locus PA2642 in contig AE004091_GR.
KEGGpae:PA2642.
NMPDRfig|208964.1.peg.2642.
PATRIC19839779. VBIPseAer58763_2765.

Organism-specific databases

PseudoCAPPA2642.

Phylogenomic databases

HOGENOMHBG488172.
OMAPSICHGC.
ProtClustDBPRK08166.

Enzyme and pathway databases

BioCycPAER208964:PA2642-MONOMER.

Family and domain databases

InterProIPR009010. Asp_de-COase-like_fold.
IPR012675. Beta-grasp_ferredoxin-type.
IPR001041. Ferredoxin.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_Fe4S4_dom.
IPR000283. NADH_UbQ_OxRdtase_75kDa_su_CS.
IPR010228. NADH_UbQ_OxRdtase_Gsu.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
[Graphical view]
Gene3DG3DSA:2.40.40.20. Asp_decarboxylase-like_fold. 1 hit.
G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit.
KOK00336.
PfamPF00111. Fer2. 1 hit.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SMARTSM00926. Molybdop_Fe4S4. 1 hit.
SM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SUPFAMSSF50692. Asp_decarb_fold. 1 hit.
SSF54292. Ferredoxin. 1 hit.
TIGRFAMsTIGR01973. NuoG. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. False negative.
PS51085. 2FE2S_FER_2. 1 hit.
PS00641. COMPLEX1_75K_1. 1 hit.
PS00642. COMPLEX1_75K_2. 1 hit.
PS00643. COMPLEX1_75K_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUOG_PSEAE
AccessionPrimary (citable) accession number: Q9I0J6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2001
Last modified: January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families