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Protein

Peptide methionine sulfoxide reductase MsrB

Gene

msrB

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47ZincPROSITE-ProRule annotation1
Metal bindingi50ZincPROSITE-ProRule annotation1
Metal bindingi96ZincPROSITE-ProRule annotation1
Metal bindingi99ZincPROSITE-ProRule annotation1
Active sitei119NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • cellular response to oxidative stress Source: PseudoCAP
  • pathogenesis Source: PseudoCAP
  • protein repair Source: InterPro
  • response to hypochlorite Source: PseudoCAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrBUniRule annotation (EC:1.8.4.12UniRule annotation)
Alternative name(s):
Peptide-methionine (R)-S-oxide reductaseUniRule annotation
Gene namesi
Name:msrBUniRule annotation
Ordered Locus Names:PA2827
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA2827.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001402861 – 132Peptide methionine sulfoxide reductase MsrBAdd BLAST132

Proteomic databases

PaxDbiQ9I016.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA2827.

Structurei

3D structure databases

ProteinModelPortaliQ9I016.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 130MsrBPROSITE-ProRule annotationAdd BLAST123

Sequence similaritiesi

Belongs to the MsrB Met sulfoxide reductase family.UniRule annotation
Contains 1 MsrB (methionine-R-sulfoxide reductase) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105E0X. Bacteria.
COG0229. LUCA.
HOGENOMiHOG000243425.
InParanoidiQ9I016.
KOiK07305.
OMAiRIEVQCK.
PhylomeDBiQ9I016.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
HAMAPiMF_01400. MsrB. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
TIGRFAMsiTIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9I016-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKIDKPLDS WREELTEEQF HICRLGGTER AFSGEYHATK TPGIYHCTCC
60 70 80 90 100
GTALFDSDAK YDSGSGWPSY FQPVDAEAVR ELDDFSHGMH RIEVRCGRCD
110 120 130
AHLGHVFPDG PRPTGLRYCI NSASLKLVPR ES
Length:132
Mass (Da):14,825
Last modified:March 1, 2001 - v1
Checksum:i640E0AEBEBFC055A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG06215.1.
PIRiA83293.
RefSeqiNP_251517.1. NC_002516.2.
WP_003090911.1. NZ_ASJY01000450.1.

Genome annotation databases

EnsemblBacteriaiAAG06215; AAG06215; PA2827.
GeneIDi878842.
KEGGipae:PA2827.
PATRICi19840187. VBIPseAer58763_2964.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG06215.1.
PIRiA83293.
RefSeqiNP_251517.1. NC_002516.2.
WP_003090911.1. NZ_ASJY01000450.1.

3D structure databases

ProteinModelPortaliQ9I016.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA2827.

Proteomic databases

PaxDbiQ9I016.

Protocols and materials databases

DNASUi878842.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG06215; AAG06215; PA2827.
GeneIDi878842.
KEGGipae:PA2827.
PATRICi19840187. VBIPseAer58763_2964.

Organism-specific databases

PseudoCAPiPA2827.

Phylogenomic databases

eggNOGiENOG4105E0X. Bacteria.
COG0229. LUCA.
HOGENOMiHOG000243425.
InParanoidiQ9I016.
KOiK07305.
OMAiRIEVQCK.
PhylomeDBiQ9I016.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
HAMAPiMF_01400. MsrB. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
TIGRFAMsiTIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSRB_PSEAE
AccessioniPrimary (citable) accession number: Q9I016
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.