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Protein

Thymidylate kinase

Gene

tmk

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.By similarity

Catalytic activityi

ATP + dTMP = ADP + dTDP.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.4.9. 5087.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinase (EC:2.7.4.9)
Alternative name(s):
dTMP kinase
Gene namesi
Name:tmk
Ordered Locus Names:PA2962
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA2962.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001553241 – 210Thymidylate kinaseAdd BLAST210

Proteomic databases

PaxDbiQ9HZN8.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA2962.

Structurei

Secondary structure

1210
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 9Combined sources6
Helixi12 – 14Combined sources3
Helixi16 – 28Combined sources13
Turni29 – 31Combined sources3
Beta strandi34 – 40Combined sources7
Helixi44 – 54Combined sources11
Helixi63 – 80Combined sources18
Helixi82 – 87Combined sources6
Beta strandi91 – 96Combined sources6
Helixi98 – 104Combined sources7
Turni105 – 109Combined sources5
Helixi113 – 124Combined sources12
Beta strandi130 – 136Combined sources7
Helixi139 – 146Combined sources8
Turni154 – 157Combined sources4
Helixi160 – 176Combined sources17
Turni178 – 180Combined sources3
Beta strandi181 – 185Combined sources5
Helixi190 – 208Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UWKX-ray1.91A/B1-210[»]
3UWOX-ray1.70A/B1-210[»]
3UXMX-ray1.95A/B/C/D2-210[»]
4E5UX-ray1.81A/B1-210[»]
4EDHX-ray1.32A/B1-210[»]
4ESHX-ray1.95A1-210[»]
4GMDX-ray1.98A/B/C/D1-210[»]
ProteinModelPortaliQ9HZN8.
SMRiQ9HZN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.Curated

Phylogenomic databases

eggNOGiENOG4108ZMD. Bacteria.
COG0125. LUCA.
HOGENOMiHOG000229078.
InParanoidiQ9HZN8.
KOiK00943.
OMAiGGIDIAE.
PhylomeDBiQ9HZN8.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HZN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGLFVTLEG PEGAGKSTNR DYLAERLRER GIEVQLTREP GGTPLAERIR
60 70 80 90 100
ELLLAPSDEP MAADTELLLM FAARAQHLAG VIRPALARGA VVLCDRFTDA
110 120 130 140 150
TYAYQGGGRG LPEARIAALE SFVQGDLRPD LTLVFDLPVE IGLARAAARG
160 170 180 190 200
RLDRFEQEDR RFFEAVRQTY LQRAAQAPER YQVLDAGLPL AEVQAGLDRL
210
LPNLLERLNG
Length:210
Mass (Da):23,109
Last modified:March 1, 2001 - v1
Checksum:i49B40C96F8ED338E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG06350.1.
PIRiE83275.
RefSeqiNP_251652.1. NC_002516.2.
WP_003091125.1. NZ_ASJY01000488.1.

Genome annotation databases

EnsemblBacteriaiAAG06350; AAG06350; PA2962.
GeneIDi878730.
KEGGipae:PA2962.
PATRICi19840477. VBIPseAer58763_3108.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG06350.1.
PIRiE83275.
RefSeqiNP_251652.1. NC_002516.2.
WP_003091125.1. NZ_ASJY01000488.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UWKX-ray1.91A/B1-210[»]
3UWOX-ray1.70A/B1-210[»]
3UXMX-ray1.95A/B/C/D2-210[»]
4E5UX-ray1.81A/B1-210[»]
4EDHX-ray1.32A/B1-210[»]
4ESHX-ray1.95A1-210[»]
4GMDX-ray1.98A/B/C/D1-210[»]
ProteinModelPortaliQ9HZN8.
SMRiQ9HZN8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA2962.

Proteomic databases

PaxDbiQ9HZN8.

Protocols and materials databases

DNASUi878730.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG06350; AAG06350; PA2962.
GeneIDi878730.
KEGGipae:PA2962.
PATRICi19840477. VBIPseAer58763_3108.

Organism-specific databases

PseudoCAPiPA2962.

Phylogenomic databases

eggNOGiENOG4108ZMD. Bacteria.
COG0125. LUCA.
HOGENOMiHOG000229078.
InParanoidiQ9HZN8.
KOiK00943.
OMAiGGIDIAE.
PhylomeDBiQ9HZN8.

Enzyme and pathway databases

BRENDAi2.7.4.9. 5087.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKTHY_PSEAE
AccessioniPrimary (citable) accession number: Q9HZN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.