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Q9HZK0

- NAGZ_PSEAE

UniProt

Q9HZK0 - NAGZ_PSEAE

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Protein

Beta-hexosaminidase

Gene

nagZ

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.UniRule annotation

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621SubstrateUniRule annotation
Binding sitei70 – 701SubstrateUniRule annotation
Binding sitei131 – 1311SubstrateUniRule annotation
Sitei172 – 1721Important for catalytic activityUniRule annotation
Active sitei174 – 1741Proton donor/acceptorUniRule annotation
Active sitei244 – 2441NucleophileUniRule annotation

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cell cycle Source: UniProtKB-KW
  3. cell division Source: UniProtKB-KW
  4. cell wall organization Source: UniProtKB-KW
  5. peptidoglycan biosynthetic process Source: UniProtKB-KW
  6. peptidoglycan turnover Source: UniProtKB-HAMAP
  7. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00544.

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidaseUniRule annotation (EC:3.2.1.52UniRule annotation)
Alternative name(s):
Beta-N-acetylhexosaminidaseUniRule annotation
N-acetyl-beta-glucosaminidaseUniRule annotation
Gene namesi
Name:nagZUniRule annotation
Ordered Locus Names:PA3005
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA3005.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332Beta-hexosaminidasePRO_0000210795Add
BLAST

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

STRINGi208964.PA3005.

Structurei

3D structure databases

ProteinModelPortaliQ9HZK0.
SMRiQ9HZK0. Positions 3-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni161 – 1622Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000248526.
InParanoidiQ9HZK0.
KOiK01207.
OMAiAHDIDLS.
OrthoDBiEOG6BCT06.
PhylomeDBiQ9HZK0.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
HAMAPiMF_00364. NagZ.
InterProiIPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00933. Glyco_hydro_3. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HZK0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQGSLMLDIG GTWLTAEDRQ ILRHPEVGGL IIFARNIEHP AQVRELCAAI
60 70 80 90 100
RAIRPDLLLA VDQEGGRVQR LRQGFVRLPA MRAIADNPNA EELAEHCGWL
110 120 130 140 150
MATEVQAVGL DLSFAPVLDL DHQRSAVVGS RAFEGDPERA ALLAGAFIRG
160 170 180 190 200
MHAAGMAATG KHFPGHGWAE ADSHVAIPED ARSLEEIRRS DLVPFARLAG
210 220 230 240 250
QLDALMPAHV IYPQVDPQPA GFSRRWLQEI LRGELKFDGV IFSDDLSMAG
260 270 280 290 300
AHVVGDAASR IEAALAAGCD MGLVCNDRAS AELALAALQR LKVTPPSRLQ
310 320 330
RMRGKGYANT DYRQQPRWLE ALSALRAAQL ID
Length:332
Mass (Da):36,101
Last modified:March 1, 2001 - v1
Checksum:iBA472E62B44A097A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG06393.1.
PIRiG83270.
RefSeqiNP_251695.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG06393; AAG06393; PA3005.
GeneIDi880216.
KEGGipae:PA3005.
PATRICi19840567. VBIPseAer58763_3153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG06393.1 .
PIRi G83270.
RefSeqi NP_251695.1. NC_002516.2.

3D structure databases

ProteinModelPortali Q9HZK0.
SMRi Q9HZK0. Positions 3-325.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA3005.

Chemistry

BindingDBi Q9HZK0.
ChEMBLi CHEMBL1667674.

Protein family/group databases

CAZyi GH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG06393 ; AAG06393 ; PA3005 .
GeneIDi 880216.
KEGGi pae:PA3005.
PATRICi 19840567. VBIPseAer58763_3153.

Organism-specific databases

PseudoCAPi PA3005.

Phylogenomic databases

eggNOGi COG1472.
HOGENOMi HOG000248526.
InParanoidi Q9HZK0.
KOi K01207.
OMAi AHDIDLS.
OrthoDBi EOG6BCT06.
PhylomeDBi Q9HZK0.

Enzyme and pathway databases

UniPathwayi UPA00544 .

Family and domain databases

Gene3Di 3.20.20.300. 1 hit.
HAMAPi MF_00364. NagZ.
InterProi IPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00933. Glyco_hydro_3. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiNAGZ_PSEAE
AccessioniPrimary (citable) accession number: Q9HZK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3