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Protein

Cell division inhibitor SulA

Gene

sulA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA repair, Septation, SOS response

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division inhibitor SulA
Gene namesi
Name:sulA
Ordered Locus Names:PA3008
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA3008.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003439691 – 161Cell division inhibitor SulAAdd BLAST161

Post-translational modificationi

Is rapidly cleaved and degraded by the Lon protease once DNA damage is repaired.By similarity

Proteomic databases

PaxDbiQ9HZJ8.

Expressioni

Inductioni

By DNA damage, as part of the SOS response.By similarity

Interactioni

Subunit structurei

Homodimer. Interacts with FtsZ.1 Publication

Protein-protein interaction databases

IntActiQ9HZJ8. 1 interactor.
STRINGi208964.PA3008.

Structurei

Secondary structure

1161
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi45 – 53Combined sources9
Helixi55 – 69Combined sources15
Beta strandi73 – 82Combined sources10
Helixi89 – 94Combined sources6
Beta strandi101 – 105Combined sources5
Helixi110 – 123Combined sources14
Beta strandi126 – 131Combined sources6
Helixi138 – 151Combined sources14
Beta strandi154 – 159Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OFTX-ray2.90A/B/C/D1-161[»]
1OFUX-ray2.10X/Y43-161[»]
ProteinModelPortaliQ9HZJ8.
SMRiQ9HZJ8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HZJ8.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni99 – 104FtsZ binding6
Regioni106 – 108FtsZ binding3
Regioni120 – 125FtsZ binding6

Sequence similaritiesi

Belongs to the SulA family.Curated

Phylogenomic databases

eggNOGiENOG4106AIJ. Bacteria.
COG5404. LUCA.
HOGENOMiHOG000247335.
KOiK13053.
OMAiQQFIHAP.
PhylomeDBiQ9HZJ8.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR004596. Cell_div_suppressor_SulA.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF03846. SulA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HZJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTSHSLPSA QLPLFQEAFW ASNGAPLLDD VIDSPSSASI EEPAAFSELS
60 70 80 90 100
LSGLPGHCLT LLAPILRELS EEQDARWLTL IAPPASLTHE WLRRAGLNRE
110 120 130 140 150
RILLLQAKDN AAALALSCEA LRLGRSHTVV SWLEPLSRAA RKQLSRAAQL
160
GQAQSLNIRL G
Length:161
Mass (Da):17,476
Last modified:March 1, 2001 - v1
Checksum:i86117EB72E03BC1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG06396.1.
PIRiA83269.
RefSeqiNP_251698.1. NC_002516.2.
WP_003091197.1. NZ_ASJY01000491.1.

Genome annotation databases

EnsemblBacteriaiAAG06396; AAG06396; PA3008.
GeneIDi880164.
KEGGipae:PA3008.
PATRICi19840573. VBIPseAer58763_3156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG06396.1.
PIRiA83269.
RefSeqiNP_251698.1. NC_002516.2.
WP_003091197.1. NZ_ASJY01000491.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OFTX-ray2.90A/B/C/D1-161[»]
1OFUX-ray2.10X/Y43-161[»]
ProteinModelPortaliQ9HZJ8.
SMRiQ9HZJ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9HZJ8. 1 interactor.
STRINGi208964.PA3008.

Proteomic databases

PaxDbiQ9HZJ8.

Protocols and materials databases

DNASUi880164.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG06396; AAG06396; PA3008.
GeneIDi880164.
KEGGipae:PA3008.
PATRICi19840573. VBIPseAer58763_3156.

Organism-specific databases

PseudoCAPiPA3008.

Phylogenomic databases

eggNOGiENOG4106AIJ. Bacteria.
COG5404. LUCA.
HOGENOMiHOG000247335.
KOiK13053.
OMAiQQFIHAP.
PhylomeDBiQ9HZJ8.

Miscellaneous databases

EvolutionaryTraceiQ9HZJ8.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR004596. Cell_div_suppressor_SulA.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF03846. SulA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSULA_PSEAE
AccessioniPrimary (citable) accession number: Q9HZJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.