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Protein

Cell division inhibitor SulA

Gene

sulA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA repair, Septation, SOS response

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division inhibitor SulA
Gene namesi
Name:sulA
Ordered Locus Names:PA3008
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA3008.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 161161Cell division inhibitor SulAPRO_0000343969Add
BLAST

Post-translational modificationi

Is rapidly cleaved and degraded by the Lon protease once DNA damage is repaired.By similarity

Proteomic databases

PaxDbiQ9HZJ8.

Expressioni

Inductioni

By DNA damage, as part of the SOS response.By similarity

Interactioni

Subunit structurei

Homodimer. Interacts with FtsZ.1 Publication

Protein-protein interaction databases

IntActiQ9HZJ8. 1 interaction.
STRINGi208964.PA3008.

Structurei

Secondary structure

1
161
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi45 – 539Combined sources
Helixi55 – 6915Combined sources
Beta strandi73 – 8210Combined sources
Helixi89 – 946Combined sources
Beta strandi101 – 1055Combined sources
Helixi110 – 12314Combined sources
Beta strandi126 – 1316Combined sources
Helixi138 – 15114Combined sources
Beta strandi154 – 1596Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OFTX-ray2.90A/B/C/D1-161[»]
1OFUX-ray2.10X/Y43-161[»]
ProteinModelPortaliQ9HZJ8.
SMRiQ9HZJ8. Positions 43-161.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HZJ8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni99 – 1046FtsZ binding
Regioni106 – 1083FtsZ binding
Regioni120 – 1256FtsZ binding

Sequence similaritiesi

Belongs to the SulA family.Curated

Phylogenomic databases

eggNOGiENOG4106AIJ. Bacteria.
COG5404. LUCA.
HOGENOMiHOG000247335.
KOiK13053.
OMAiQQFIHAP.
OrthoDBiEOG6R5C7P.
PhylomeDBiQ9HZJ8.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR004596. Cell_div_suppressor_SulA.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF03846. SulA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HZJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTSHSLPSA QLPLFQEAFW ASNGAPLLDD VIDSPSSASI EEPAAFSELS
60 70 80 90 100
LSGLPGHCLT LLAPILRELS EEQDARWLTL IAPPASLTHE WLRRAGLNRE
110 120 130 140 150
RILLLQAKDN AAALALSCEA LRLGRSHTVV SWLEPLSRAA RKQLSRAAQL
160
GQAQSLNIRL G
Length:161
Mass (Da):17,476
Last modified:March 1, 2001 - v1
Checksum:i86117EB72E03BC1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG06396.1.
PIRiA83269.
RefSeqiNP_251698.1. NC_002516.2.
WP_003091197.1. NZ_ASJY01000491.1.

Genome annotation databases

EnsemblBacteriaiAAG06396; AAG06396; PA3008.
GeneIDi880164.
KEGGipae:PA3008.
PATRICi19840573. VBIPseAer58763_3156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG06396.1.
PIRiA83269.
RefSeqiNP_251698.1. NC_002516.2.
WP_003091197.1. NZ_ASJY01000491.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OFTX-ray2.90A/B/C/D1-161[»]
1OFUX-ray2.10X/Y43-161[»]
ProteinModelPortaliQ9HZJ8.
SMRiQ9HZJ8. Positions 43-161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9HZJ8. 1 interaction.
STRINGi208964.PA3008.

Proteomic databases

PaxDbiQ9HZJ8.

Protocols and materials databases

DNASUi880164.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG06396; AAG06396; PA3008.
GeneIDi880164.
KEGGipae:PA3008.
PATRICi19840573. VBIPseAer58763_3156.

Organism-specific databases

PseudoCAPiPA3008.

Phylogenomic databases

eggNOGiENOG4106AIJ. Bacteria.
COG5404. LUCA.
HOGENOMiHOG000247335.
KOiK13053.
OMAiQQFIHAP.
OrthoDBiEOG6R5C7P.
PhylomeDBiQ9HZJ8.

Miscellaneous databases

EvolutionaryTraceiQ9HZJ8.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR004596. Cell_div_suppressor_SulA.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF03846. SulA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
  2. "Crystal structure of the SOS cell division inhibitor SulA and in complex with FtsZ."
    Cordell S.C., Robinson E.J., Loewe J.
    Proc. Natl. Acad. Sci. U.S.A. 100:7889-7894(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) UNCOMPLEXED AND IN COMPLEX WITH FTSZ, SUBUNIT.
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiSULA_PSEAE
AccessioniPrimary (citable) accession number: Q9HZJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.