Fatty acid oxidation complex subunit alpha

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Reviewed, UniProtKB/Swiss-Prot Q9HZJ2 (FADB_PSEAE)

Last modified June 16, 2009. Version 53. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Fatty acid oxidation complex subunit alpha
Including the following 2 domains:
    1- Recommended name:
            Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase
              EC=4.2.1.17
              EC=5.3.3.8
              EC=5.1.2.3
    2- Recommended name:
            3-hydroxyacyl-CoA dehydrogenase
              EC=1.1.1.35

Gene names

Name:	fadB
Ordered Locus Names:	PA3014

Organism

Pseudomonas aeruginosa [Complete proteome] [HAMAP]

Taxonomic identifier

287 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

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Protein attributes

Sequence length	715 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

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General annotation (Comments)

Function	Catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities By similarity.
Catalytic activity	(S)-3-hydroxyacyl-CoA + NAD⁺ = 3-oxoacyl-CoA + NADH. HAMAP MF_01621 (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H₂O. HAMAP MF_01621 (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA. HAMAP MF_01621 (3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA. HAMAP MF_01621
Pathway	Lipid metabolism; fatty acid beta-oxidation. HAMAP MF_01621
Subunit structure	Heterotetramer of two alpha chains (fadB) and two beta chains (fadA) By similarity.
Sequence similarities	In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

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Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid degradation Lipid metabolism
Ligand	NAD
Molecular function	Isomerase Lyase Oxidoreductase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	fatty acid catabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	fatty acid beta-oxidation multienzyme complex Inferred from electronic annotation. Source: InterPro
Molecular function	3-hydroxyacyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: HAMAP 3-hydroxybutyryl-CoA epimerase activity Inferred from electronic annotation. Source: HAMAP coenzyme binding Inferred from electronic annotation. Source: InterPro dodecenoyl-CoA delta-isomerase activity Inferred from electronic annotation. Source: HAMAP enoyl-CoA hydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 715

715

Fatty acid oxidation complex subunit alpha HAMAP MF_01621

PRO_0000109274

Regions

Region

1 – 190

190

Enoyl-CoA hydratase/isomerase By similarity

Region

312 – 715

404

3-hydroxyacyl-CoA dehydrogenase By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

Q9HZJ2-1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 7ED8573BE8F31101
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FASTA

715

76,954

        10         20         30         40         50         60 
MIYQGKAITV KPLEGGIVEL NFDLKGESVN KFNRLTLSEL RAAVDAIKAD ASVKGVIVTS 

        70         80         90        100        110        120 
GKDVFIVGAD ITEFVDNFQL PDEELMAGNL EANKIFSDFE DLDVPTVAAI NGIALGGGLE 

       130        140        150        160        170        180 
MCLAADFRVM SATAKVGLPE VKLGIYPGFG GTVRLPRLIG CDNAVEWIAS GKENKAEDAL 

       190        200        210        220        230        240 
KVGAVDAVVA PEQLQAAALD LAKRAVAGEL DHKARRQPKL EKLKLNAIEQ MMAFETAKGF 

       250        260        270        280        290        300 
VAGQAGPNYP APVEAIKSIQ KAANFGRDKA LEVEAAGFVK LAKTSVAQSL IGLFLNDQEL 

       310        320        330        340        350        360 
KKKAKKYDEV AKDVKLAAVL GAGIMGGGIA YQSALKGTPI LMKDIREEGI QMGLNEAAKL 

       370        380        390        400        410        420 
LGKRVEKGRL TPAKMAEALN GIRPTMSYGD FGNVDIVVEA VVENPKVKQA VLAEVEGAVK 

       430        440        450        460        470        480 
EDAIIASNTS TISISLLAQA LKRPENFCGM HFFNPVHMMP LVEVIRGEKT GETAIATTVA 

       490        500        510        520        530        540 
YAKKMGKSPI VVNDCPGFLV NRVLFPYFGG FAKLLSFGVD FVRIDKVMEK FGWPMGPAYL 

       550        560        570        580        590        600 
SDVVGIDTGH HGRDVMAEGF PDRMAVEGKT AVDVMYEANR LGQKNGKGFY AYETDKRGKP 

       610        620        630        640        650        660 
KKVTDPQAYE VLKPIVVEQR EVTDEDIVNF MMIPLCLETV RCLEDGIVET AAEADMGLIY 

       670        680        690        700        710 
GIGFPPFRGG ALRYIDSIGV AEFVALADKY AELGALYHPT AKLREMAKNG QKFFG

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Cross-references

Sequence databases
	AE004091 Genomic DNA. Translation: AAG06402.1.
PIR	G83269.
RefSeq	NP_251704.1.
3D structure databases
HSSP	HSSP built from PDB template 3HDH based on UniProtKB P00348.
SMR	Q9HZJ2. Positions 1-715.
ModBase	Search...
Genome annotation databases
GeneID	878680.
GenomeReviews	Gene locus PA3014 in contig AE004091_GR.
KEGG	pae:PA3014.
Organism-specific databases
PseudoCAP	PA3014.
CMR	Search...
Phylogenomic databases
HOGENOM	Q9HZJ2.
OMA	Q9HZJ2. ANNGSYY.
Enzyme and pathway databases
BioCyc	PAER208964:PA3014-MON.
BRENDA	1.1.1.35. 354. 4.2.1.17. 354. 5.1.2.3. 354. 5.3.3.8. 354.
Family and domain databases
HAMAP	MF_01621. [Tree]
InterPro	IPR006180. 3-OHacyl-CoA_DH_CS. IPR006176. 3-OHacyl-CoA_DH_NAD-bd. IPR006108. 3HC_DH_C. IPR001753. Crotonase_core. IPR013328. DH_multihelical. IPR018376. Enoyl-CoA_hyd/isom_CS. IPR012799. FadB. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF00725. 3HCDH. 1 hit. PF02737. 3HCDH_N. 1 hit. PF00378. ECH. 1 hit. [Graphical view]
TIGRFAMs	TIGR02437. FadB. 1 hit.
PROSITE	PS00067. 3HCDH. 1 hit. PS00166. ENOYL_COA_HYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

FADB_PSEAE

Accession

Primary (citable) accession number: Q9HZJ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	March 1, 2001
Last modified:	June 16, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents