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Protein

Histidinol-phosphate aminotransferase 2

Gene

hisC2

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.

Cofactori

Pathwayi: L-histidine biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase regulatory subunit (hisZ), ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit hisF1 (hisF1), Imidazole glycerol phosphate synthase subunit HisH 2 (hisH2), Imidazole glycerol phosphate synthase subunit HisH 1 (hisH1), Putative imidazole glycerol phosphate synthase subunit hisF2 (hisF2)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase 2 (hisC2), Histidinol-phosphate aminotransferase 1 (hisC1)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-3225-MONOMER
UniPathwayiUPA00031; UER00012

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphate aminotransferase 2 (EC:2.6.1.9)
Alternative name(s):
Imidazole acetol-phosphate transaminase 2
Gene namesi
Name:hisC2
Ordered Locus Names:PA3165
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA3165

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001534181 – 369Histidinol-phosphate aminotransferase 2Add BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei229N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ9HZ68

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi208964.PA3165

Structurei

3D structure databases

ProteinModelPortaliQ9HZ68
SMRiQ9HZ68
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CIH Bacteria
COG0079 LUCA
HOGENOMiHOG000288510
InParanoidiQ9HZ68
KOiK00817
OMAiPTFDGYP
PhylomeDBiQ9HZ68

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01023 HisC_aminotrans_2, 1 hit
InterProiView protein in InterPro
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR005861 HisP_aminotrans
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01141 hisC, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HZ68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDFLALAQP GVQKLSPYVP GKPVDELARE LGIDPAAIVK LASNENPLGA
60 70 80 90 100
SPKALEAIRA ELAELTRYPD GNGFELKRKL AERCAVDAAQ VTLGNGSNDI
110 120 130 140 150
LDLVARAYLA PGLNAVFSEH AFAVYPIATQ AVGAEGRAVK ARAWGHDLEA
160 170 180 190 200
MLAAIDGQTR VVFVANPNNP TGTWFGADAL ERFLAQVPAE VLVVLDEAYI
210 220 230 240 250
EYAEGDELPD GLDYLARHPN LLVSRTFSKA YGLASLRVGY ALSSKAVADV
260 270 280 290 300
LNRVRQPFNV NSLALAAACA ALDDHDYLAQ SRRLNDSGMA QLEDGFHALG
310 320 330 340 350
LSWIPSKGNF IAVDLARDAG PVYQALLREG VIVRPVAGYG MPTFLRVSIG
360
LPEENDRFLQ ALGKVLAHD
Length:369
Mass (Da):39,483
Last modified:March 1, 2001 - v1
Checksum:iCE912DC95699652E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG06553.1
PIRiF83250
RefSeqiNP_251855.1, NC_002516.2
WP_003115433.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG06553; AAG06553; PA3165
GeneIDi882694
KEGGipae:PA3165
PATRICifig|208964.12.peg.3308

Similar proteinsi

Entry informationi

Entry nameiHIS82_PSEAE
AccessioniPrimary (citable) accession number: Q9HZ68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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