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Protein

Ribosomal large subunit pseudouridine synthase B

Gene

rluB

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Responsible for synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA.By similarity

Catalytic activityi

23S rRNA uridine(2605) = 23S rRNA pseudouridine(2605).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei119NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal large subunit pseudouridine synthase B (EC:5.4.99.22)
Alternative name(s):
23S rRNA pseudouridine(2605) synthase
rRNA pseudouridylate synthase B
rRNA-uridine isomerase B
Gene namesi
Name:rluB
Ordered Locus Names:PA3179
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA3179.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000999881 – 386Ribosomal large subunit pseudouridine synthase BAdd BLAST386

Proteomic databases

PaxDbiQ9HZ55.
PRIDEiQ9HZ55.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA3179.

Structurei

3D structure databases

ProteinModelPortaliQ9HZ55.
SMRiQ9HZ55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 75S4 RNA-bindingPROSITE-ProRule annotationAdd BLAST62

Sequence similaritiesi

Belongs to the pseudouridine synthase RsuA family.Curated
Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105FE9. Bacteria.
COG1187. LUCA.
HOGENOMiHOG000044954.
InParanoidiQ9HZ55.
KOiK06178.
OMAiEAWITQG.
PhylomeDBiQ9HZ55.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR000748. PsdUridine_synth_RsuA/RluB/E/F.
IPR018496. PsdUridine_synth_RsuA/RluB_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00093. TIGR00093. 1 hit.
PROSITEiPS01149. PSI_RSU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HZ55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDTPENPHV PVGEKLQKVL ARLGVGSRRD VEVWIAEGRV NVNGSVASLG
60 70 80 90 100
QRVDSHDAIT VDGHLIRREE AAESVRRVLI YNKPEGEVCT RDDPEGRPTI
110 120 130 140 150
FDRLPRLRTG RWINVGRLDI NTTGLLLFTT DGELANRLMH PSYEMDREYA
160 170 180 190 200
VRVRGEVTEE MIERLLNGVM LEDGPAKFSD IQQAPGGEGF NHWYHCVVME
210 220 230 240 250
GRNREVRRLW ESQGLVVSRL KRVRFGPVFL TSELTMGRYR EMDQREIDIL
260 270 280 290 300
SEEVGLKPVA LPGMTTKARE KAERQQRKQA RPLARSERPE AGRKRAPRRE
310 320 330 340 350
DGENAARRAP ASRPARGPQP SAERKGREQG TPVAERPRES NRKPRPSKPR
360 370 380
DERPASAPGD KPAARKPQVK RRPKPAGDGM RPGFRR
Length:386
Mass (Da):43,725
Last modified:March 1, 2001 - v1
Checksum:iC47840D7C0E5C0CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG06567.1.
PIRiE83247.
RefSeqiNP_251869.1. NC_002516.2.
WP_003113439.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG06567; AAG06567; PA3179.
GeneIDi882705.
KEGGipae:PA3179.
PATRICi19840925. VBIPseAer58763_3323.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG06567.1.
PIRiE83247.
RefSeqiNP_251869.1. NC_002516.2.
WP_003113439.1. NC_002516.2.

3D structure databases

ProteinModelPortaliQ9HZ55.
SMRiQ9HZ55.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA3179.

Proteomic databases

PaxDbiQ9HZ55.
PRIDEiQ9HZ55.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG06567; AAG06567; PA3179.
GeneIDi882705.
KEGGipae:PA3179.
PATRICi19840925. VBIPseAer58763_3323.

Organism-specific databases

PseudoCAPiPA3179.

Phylogenomic databases

eggNOGiENOG4105FE9. Bacteria.
COG1187. LUCA.
HOGENOMiHOG000044954.
InParanoidiQ9HZ55.
KOiK06178.
OMAiEAWITQG.
PhylomeDBiQ9HZ55.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR000748. PsdUridine_synth_RsuA/RluB/E/F.
IPR018496. PsdUridine_synth_RsuA/RluB_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00093. TIGR00093. 1 hit.
PROSITEiPS01149. PSI_RSU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRLUB_PSEAE
AccessioniPrimary (citable) accession number: Q9HZ55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.