ID   Q9HZ23_PSEAE            Unreviewed;       463 AA.
AC   Q9HZ23;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   27-MAR-2024, entry version 119.
DE   SubName: Full=CyaB {ECO:0000313|EMBL:AAG06605.1};
GN   Name=cyaB {ECO:0000313|EMBL:AAG06605.1};
GN   OrderedLocusNames=PA3217 {ECO:0000313|EMBL:AAG06605.1};
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964 {ECO:0000313|EMBL:AAG06605.1, ECO:0000313|Proteomes:UP000002438};
RN   [1] {ECO:0000313|EMBL:AAG06605.1, ECO:0000313|Proteomes:UP000002438}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
RC   1C / PRS 101 / PAO1 {ECO:0000313|Proteomes:UP000002438};
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.Q., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R., Smith K.,
RA   Spencer D., Wong G.K., Wu Z., Paulsen I.T., Reizer J., Saier M.H.,
RA   Hancock R.E., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
RN   [2] {ECO:0007829|PDB:3R5G}
RP   X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 220-416.
RX   PubMed=22226839; DOI=10.1016/j.jmb.2011.12.045;
RA   Topal H., Fulcher N.B., Bitterman J., Salazar E., Buck J., Levin L.R.,
RA   Cann M.J., Wolfgang M.C., Steegborn C.;
RT   "Crystal structure and regulation mechanisms of the CyaB adenylyl cyclase
RT   from the human pathogen Pseudomonas aeruginosa.";
RL   J. Mol. Biol. 416:271-286(2012).
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DR   EMBL; AE004091; AAG06605.1; -; Genomic_DNA.
DR   PIR; E83242; E83242.
DR   RefSeq; NP_251907.1; NC_002516.2.
DR   RefSeq; WP_003124349.1; NZ_QZGE01000019.1.
DR   PDB; 3R5G; X-ray; 1.50 A; A/B=220-416.
DR   PDBsum; 3R5G; -.
DR   AlphaFoldDB; Q9HZ23; -.
DR   SMR; Q9HZ23; -.
DR   STRING; 208964.PA3217; -.
DR   PaxDb; 208964-PA3217; -.
DR   DNASU; 882555; -.
DR   GeneID; 882555; -.
DR   KEGG; pae:PA3217; -.
DR   PATRIC; fig|208964.12.peg.3364; -.
DR   PseudoCAP; PA3217; -.
DR   HOGENOM; CLU_047397_0_0_6; -.
DR   InParanoid; Q9HZ23; -.
DR   OrthoDB; 9806704at2; -.
DR   PhylomeDB; Q9HZ23; -.
DR   BioCyc; PAER208964:G1FZ6-3277-MONOMER; -.
DR   BRENDA; 4.6.1.1; 5087.
DR   PHI-base; PHI:7164; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IMP:PseudoCAP.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IMP:PseudoCAP.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR007894; MASE2.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF05230; MASE2; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:3R5G}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002438};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        46..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        77..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          229..364
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   463 AA;  51404 MW;  FE4B035F2C508EDB CRC64;
     MKPTLPDRSP TSRSVASMRE YYSRVLAYIA CGASIAAGTY TQYFSYGILW MVPYALLYPH
     LAYHLGQRFR QHDPRKVTRA LLAVDAVHCG LGMALLGFSV VPSLMFLLVL SFTALVIGGL
     RLLGMALLVS ASSALLVAVL VAPPLLGNTP VEVAAVSILF CGLYICITAF FGHQQGLRLA
     QVRQEIAREQ EKAARLARNL AKYLSPQVWE MIFSGKKSVR LETQRKKLTV FFSDIRGFTE
     LSEELEAEAL TDLLNNYLNE MSKIALKYGG TIDKFVGDCV MVFFGDPSTQ GAKKDAVAAV
     SMGIAMRKHM KVLRQQWRAQ GITKPLEIRM GINTGYCTVG NFGADTRMDY TIIGREVNLA
     SRLESASEAG EILISHETYS LIKDVIMCRD KGQIAVKGFS RPVQIYQVVD SRRDLGAAPS
     YVEHELPGFS MYLDTNNIQN YDKERVIQAL QQAAERLRDK VIL
//