Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

CyaB

Gene

cyaB

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • adenylate cyclase activity Source: PseudoCAP

GO - Biological processi

  • cAMP biosynthetic process Source: PseudoCAP
  • intracellular signal transduction Source: InterPro
  • pathogenesis Source: PseudoCAP
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
CyaBImported
Gene namesi
Name:cyaBImported
Ordered Locus Names:PA3217Imported
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)Imported
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA3217.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi208964.PA3217.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R5GX-ray1.50A/B220-416[»]
ProteinModelPortaliQ9HZ23.
SMRiQ9HZ23. Positions 221-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000225757.
InParanoidiQ9HZ23.
KOiK05345.
OMAiSSYVEHE.
OrthoDBiEOG690M9K.
PhylomeDBiQ9HZ23.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR007894. MASE2.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 1 hit.
PF05230. MASE2. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HZ23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPTLPDRSP TSRSVASMRE YYSRVLAYIA CGASIAAGTY TQYFSYGILW
60 70 80 90 100
MVPYALLYPH LAYHLGQRFR QHDPRKVTRA LLAVDAVHCG LGMALLGFSV
110 120 130 140 150
VPSLMFLLVL SFTALVIGGL RLLGMALLVS ASSALLVAVL VAPPLLGNTP
160 170 180 190 200
VEVAAVSILF CGLYICITAF FGHQQGLRLA QVRQEIAREQ EKAARLARNL
210 220 230 240 250
AKYLSPQVWE MIFSGKKSVR LETQRKKLTV FFSDIRGFTE LSEELEAEAL
260 270 280 290 300
TDLLNNYLNE MSKIALKYGG TIDKFVGDCV MVFFGDPSTQ GAKKDAVAAV
310 320 330 340 350
SMGIAMRKHM KVLRQQWRAQ GITKPLEIRM GINTGYCTVG NFGADTRMDY
360 370 380 390 400
TIIGREVNLA SRLESASEAG EILISHETYS LIKDVIMCRD KGQIAVKGFS
410 420 430 440 450
RPVQIYQVVD SRRDLGAAPS YVEHELPGFS MYLDTNNIQN YDKERVIQAL
460
QQAAERLRDK VIL
Length:463
Mass (Da):51,404
Last modified:March 1, 2001 - v1
Checksum:iFE4B035F2C508EDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG06605.1.
PIRiE83242.
RefSeqiNP_251907.1. NC_002516.2.
WP_003124349.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG06605; AAG06605; PA3217.
GeneIDi882555.
KEGGipae:PA3217.
PATRICi19841007. VBIPseAer58763_3364.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG06605.1.
PIRiE83242.
RefSeqiNP_251907.1. NC_002516.2.
WP_003124349.1. NC_002516.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R5GX-ray1.50A/B220-416[»]
ProteinModelPortaliQ9HZ23.
SMRiQ9HZ23. Positions 221-416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA3217.

Protocols and materials databases

DNASUi882555.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG06605; AAG06605; PA3217.
GeneIDi882555.
KEGGipae:PA3217.
PATRICi19841007. VBIPseAer58763_3364.

Organism-specific databases

PseudoCAPiPA3217.

Phylogenomic databases

HOGENOMiHOG000225757.
InParanoidiQ9HZ23.
KOiK05345.
OMAiSSYVEHE.
OrthoDBiEOG690M9K.
PhylomeDBiQ9HZ23.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR007894. MASE2.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 1 hit.
PF05230. MASE2. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228Imported.
  2. "Crystal structure and regulation mechanisms of the CyaB adenylyl cyclase from the human pathogen Pseudomonas aeruginosa."
    Topal H., Fulcher N.B., Bitterman J., Salazar E., Buck J., Levin L.R., Cann M.J., Wolfgang M.C., Steegborn C.
    J. Mol. Biol. 416:271-286(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 220-416.

Entry informationi

Entry nameiQ9HZ23_PSEAE
AccessioniPrimary (citable) accession number: Q9HZ23
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: June 24, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.