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Q9HYN5 (Q9HYN5_PSEAE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length115 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region22 – 243Fucose binding PDB 1W8F PDB 2JDH PDB 2JDK PDB 2JDM PDB 2JDN PDB 2VUC PDB 2VUD PDB 1OXC PDB 1UZV PDB 1W8H
Region22 – 243Mannose binding PDB 1OUR PDB 1OVS
Region23 – 242Sulfate 3 binding PDB 2JDU
Region44 – 463Sulfate 7 binding PDB 1W8F
Region45 – 473Sulfate 8 binding PDB 1OUS PDB 1W8F PDB 2BOJ PDB 2BP6 PDB 2JDH PDB 2JDK PDB 2JDN PDB 2JDU PDB 3ZDV
Region45 – 473Sulfate 9 binding PDB 2JDM PDB 2JDU PDB 2VUC PDB 2VUD PDB 1UZV PDB 1W8H
Region97 – 1059Fucose binding PDB 1W8F PDB 2JDH PDB 2JDK PDB 2JDM PDB 2JDN PDB 2VUC PDB 2VUD PDB 1OXC PDB 1UZV PDB 1W8H
Region97 – 1059Mannose binding PDB 1OUR PDB 1OVS
Region97 – 1004Sulfate 4 binding PDB 2JDU

Sites

Metal binding221Calcium 1; via carbonyl oxygen
Metal binding961Calcium 2
Metal binding1001Calcium 2
Metal binding1021Calcium 1
Metal binding1021Calcium 2
Metal binding1041Calcium 1
Metal binding1051Calcium 1
Metal binding1051Calcium 2
Metal binding1151Calcium 1; via carbonyl oxygen PDB 1W8F PDB 2JDM PDB 2JDN PDB 2JDP PDB 2VUC PDB 3DCQ PDB 1OVP PDB 1OXC PDB 1UZV PDB 3ZDV
Metal binding1151Calcium 2; via carbonyl oxygen PDB 2BOJ PDB 2JDM PDB 2JDU PDB 2JDY PDB 2VUC PDB 2VUD PDB 3DCQ
Binding site141Sulfate 1 PDB 2BP6 PDB 2JDM PDB 2JDN PDB 2JDU PDB 2VUD PDB 1OXC PDB 1UZV
Binding site231Sulfate 4 PDB 2JDU
Binding site241N-acetyl-D-glucosamine PDB 2JDH PDB 2JDK
Binding site241Sulfate 2 PDB 1OUX
Binding site341Sulfate 5 PDB 2JDU
Binding site401Sulfate 6; via carbonyl oxygen PDB 1W8H
Binding site541Sulfate 6 PDB 1W8H
Binding site601Sulfate 5 PDB 2JDU
Binding site971N-acetyl-D-glucosamine PDB 2JDH PDB 2JDK PDB 1W8H
Binding site971Sulfate 3 PDB 2JDU
Binding site1001Galactose PDB 1W8H
Binding site1051Sulfate 3 PDB 2JDU
Binding site1051Sulfate 4 PDB 2JDU
Binding site1151Fucose; via amide nitrogen and carbonyl oxygen PDB 1W8F PDB 2JDH PDB 2JDK PDB 2JDM PDB 2JDN PDB 2VUC PDB 2VUD PDB 1OXC PDB 1UZV PDB 1W8H
Binding site1151Mannose; via amide nitrogen and carbonyl oxygen PDB 1OUR PDB 1OVS

Sequences

Sequence LengthMass (Da)Tools
Q9HYN5 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 616D8249512CDD7D

FASTA11511,863
        10         20         30         40         50         60 
MATQGVFTLP ANTRFGVTAF ANSSGTQTVN VLVNNETAAT FSGQSTNNAV IGTQVLNSGS 

        70         80         90        100        110 
SGKVQVQVSV NGRPSDLVSA QVILTNELNF ALVGSEDGTD NDYNDAVVVI NWPLG 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen."
Stover C.K., Pham X.Q., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. expand/collapse author list , Kas A., Larbig K., Lim R., Smith K., Spencer D., Wong G.K., Wu Z., Paulsen I.T., Reizer J., Saier M.H., Hancock R.E., Lory S., Olson M.V.
Nature 406:959-964(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
[2]"Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients."
Mitchell E., Houles C., Sudakevitz D., Wimmerova M., Gautier C., Perez S., Wu A.M., Gilboa-Garber N., Imberty A.
Nat. Struct. Biol. 9:918-921(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS) IN COMPLEX WITH CALCIUM AND FUCOSE.
[3]"Structural basis of carbohydrate recognition by the lectin LecB from Pseudomonas aeruginosa."
Loris R., Tielker D., Jaeger K.E., Wyns L.
J. Mol. Biol. 331:861-870(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.20 ANGSTROMS) OF 2-115 IN COMPLEX WITH CALCIUM; FUCOSE; MANNOSE AND SULFATE.
[4]"Structural basis for the interaction between human milk oligosaccharides and the bacterial lectin PA-IIL of Pseudomonas aeruginosa."
Perret S., Sabin C., Dumon C., Pokorna M., Gautier C., Galanina O., Ilia S., Bovin N., Nicaise M., Desmadril M., Gilboa-Garber N., Wimmerova M., Mitchell E.P., Imberty A.
Biochem. J. 389:325-332(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.05 ANGSTROMS) IN COMPLEX WITH CALCIUM; FUCOSE; GALACTOSE; N-ACETYL-D-GLUCOSAMINE AND SULFATE.
[5]"High affinity fucose binding of Pseudomonas aeruginosa lectin PA-IIL: 1.0 A resolution crystal structure of the complex combined with thermodynamics and computational chemistry approaches."
Mitchell E.P., Sabin C., Snajdrova L., Pokorna M., Perret S., Gautier C., Hofr C., Gilboa-Garber N., Koca J., Wimmerova M., Imberty A.
Proteins 58:735-746(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.00 ANGSTROMS) OF 2-115 IN COMPLEX WITH CALCIUM; FUCOSE AND SULFATE.
[6]"Binding of different monosaccharides by lectin PA-IIL from Pseudomonas aeruginosa: thermodynamics data correlated with X-ray structures."
Sabin C., Mitchell E.P., Pokorna M., Gautier C., Utille J.P., Wimmerova M., Imberty A.
FEBS Lett. 580:982-987(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 2-115 IN COMPLEX WITH CALCIUM AND SULFATE.
[7]"Engineering of PA-IIL lectin from Pseudomonas aeruginosa - Unravelling the role of the specificity loop for sugar preference."
Adam J., Pokorna M., Sabin C., Mitchell E.P., Imberty A., Wimmerova M.
BMC Struct. Biol. 7:36-36(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS) IN COMPLEX WITH CALCIUM; FUCOSE AND SULFATE.
[8]"X-ray structures and thermodynamics of the interaction of PA-IIL from Pseudomonas aeruginosa with disaccharide derivatives."
Marotte K., Sabin C., Preville C., Moume-Pymbock M., Wimmerova M., Mitchell E.P., Imberty A., Roy R.
ChemMedChem 2:1328-1338(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.10 ANGSTROMS) IN COMPLEX WITH CALCIUM; FUCOSE; N-ACETYL-D-GLUCOSAMINE AND SULFATE.
[9]"Inhibition and dispersion of Pseudomonas aeruginosa biofilms by glycopeptide dendrimers targeting the fucose-specific lectin LecB."
Johansson E.M., Crusz S.A., Kolomiets E., Buts L., Kadam R.U., Cacciarini M., Bartels K.M., Diggle S.P., Camara M., Williams P., Loris R., Nativi C., Rosenau F., Jaeger K.E., Darbre T., Reymond J.L.
Chem. Biol. 15:1249-1257(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 2-115 IN COMPLEX WITH CALCIUM.
[10]"Fucose-Derived Glycomimetics as High Affinity Ligands for Bacterial Lectin Pa-Iil from Pseudomonas Aeruginosa."
Beha S., Marotte K., Sabin C., Mitchell E.P., Imberty A., Roy R.
Submitted (MAY-2008) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS) OF 2-115 IN COMPLEX WITH CALCIUM; FUCOSE AND SULFATE.
[11]"Discovery of two classes of potent glycomimetic inhibitors of Pseudomonas aeruginosa LecB with distinct binding modes."
Hauck D., Joachim I., Frommeyer B., Varrot A., Philipp B., Moller H.M., Imberty A., Exner T.E., Titz A.
ACS Chem. Biol. 8:1775-1784(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.41 ANGSTROMS) IN COMPLEX WITH CALCIUM AND SULFATE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004091 Genomic DNA. Translation: AAG06749.1.
PIRH83225.
RefSeqNP_252051.1. NC_002516.2.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1GZTX-ray1.30A/B/C/D1-115[»]
1OURX-ray1.42A2-115[»]
1OUSX-ray1.20A/B/C/D2-115[»]
1OUXX-ray2.00A/B/C/D2-115[»]
1OVPX-ray1.40A2-115[»]
1OVSX-ray1.75A/B/C/D2-115[»]
1OXCX-ray1.20A/B/C/D2-115[»]
1UZVX-ray1.00A/B/C/D2-115[»]
1W8FX-ray1.05A/B/C/D1-115[»]
1W8HX-ray1.75A/B/C/D1-115[»]
2BOJX-ray1.80A/B/C/D2-115[»]
2BP6X-ray1.50A/B/C/D2-115[»]
2JDHX-ray1.10A/B/C/D1-115[»]
2JDKX-ray1.10A/B/C/D1-115[»]
2JDMX-ray1.70A/B/C/D1-115[»]
2JDNX-ray1.30A/B/C/D1-115[»]
2JDPX-ray1.30A/B/C/D1-115[»]
2JDUX-ray1.50A/B/C/D1-115[»]
2JDYX-ray1.70A/B/C/D1-115[»]
2VUCX-ray1.30A/B/C/D2-115[»]
2VUDX-ray1.70A/B/C/D2-115[»]
3DCQX-ray1.80A/B/C/D2-115[»]
3ZDVX-ray1.41A/B/C/D1-115[»]
ProteinModelPortalQ9HYN5.
SMRQ9HYN5. Positions 2-115.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING208964.PA3361.

Protocols and materials databases

DNASU882528.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG06749; AAG06749; PA3361.
GeneID882528.
KEGGpae:PA3361.
PATRIC19841323. VBIPseAer58763_3520.

Organism-specific databases

PseudoCAPPA3361.

Phylogenomic databases

HOGENOMHOG000110720.
OMANDYNDGI.
OrthoDBEOG67X1RS.

Family and domain databases

Gene3D2.60.120.400. 1 hit.
InterProIPR010907. Ca-mediated_lectin.
IPR016927. Lectin_sugar-bd.
[Graphical view]
PfamPF07472. PA-IIL. 1 hit.
[Graphical view]
PIRSFPIRSF029595. Lectin_LecB. 1 hit.
SUPFAMSSF82026. SSF82026. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ9HYN5.

Entry information

Entry nameQ9HYN5_PSEAE
AccessionPrimary (citable) accession number: Q9HYN5
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)