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Q9HYG8 (GCH11_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I 1
Short name=GTP-CH-I 1
Gene names
Name:folE1
Ordered Locus Names:PA3438
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) [Reference proteome] [HAMAP]
Taxonomic identifier208964 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length186 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Homopolymer By similarity. HAMAP-Rule MF_00223

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 186186GTP cyclohydrolase 1 1 HAMAP-Rule MF_00223
PRO_0000119428

Sequences

Sequence LengthMass (Da)Tools
Q9HYG8 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 1F53E719217C519F

FASTA18620,833
        10         20         30         40         50         60 
MNPALSQHYR EILVGLGEDP QREGLLDTPK RAAKAMQYLC HGYGQTLEEI VNGALFASDN 

        70         80         90        100        110        120 
DEMVIVRDIE LYSLCEHHLL PFIGKAHVAY IPTGKVLGLS KVARIVDMFA RRLQIQENLT 

       130        140        150        160        170        180 
RQIAEAVRQV TSAAGVAVVI EAQHMCMMMR GVEKQNSQMF TSVMLGAFRD SNTTRQEFLQ 


LIGRSK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004091 Genomic DNA. Translation: AAG06826.1.
PIRD83217.
RefSeqNP_252128.1. NC_002516.2.

3D structure databases

ProteinModelPortalQ9HYG8.
SMRQ9HYG8. Positions 11-179.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING208964.PA3438.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID878765.
KEGGpae:PA3438.
PATRIC19841483. VBIPseAer58763_3599.

Organism-specific databases

PseudoCAPPA3438.

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMAFTEWLAD.
OrthoDBEOG6XHC8G.
ProtClustDBPRK12606.

Enzyme and pathway databases

UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH11_PSEAE
AccessionPrimary (citable) accession number: Q9HYG8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways