Reviewed, UniProtKB/Swiss-Prot Q9HYG8 (GCH11_PSEAE)

Names and origin

Protein names

Recommended name:
    GTP cyclohydrolase 1 1
    EC=3.5.4.16
Alternative name(s):
    GTP cyclohydrolase I 1
      Short name=GTP-CH-I 1

Gene names

Name:	folE1
Ordered Locus Names:	PA3438

Organism

Pseudomonas aeruginosa [Complete proteome] [HAMAP]

Taxonomic identifier

287 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	186 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP MF_00223
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP MF_00223
Subunit structure	Homopolymer By similarity. HAMAP MF_00223
Sequence similarities	Belongs to the GTP cyclohydrolase I family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	GTP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 186	186	GTP cyclohydrolase 1 1 HAMAP MF_00223		PRO_0000119428

Sequences

	Sequence		Length	Mass (Da)
	Q9HYG8-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 1F53E719217C519F	FASTA	186	20,833
	10 20 30 40 50 60 MNPALSQHYR EILVGLGEDP QREGLLDTPK RAAKAMQYLC HGYGQTLEEI VNGALFASDN 70 80 90 100 110 120 DEMVIVRDIE LYSLCEHHLL PFIGKAHVAY IPTGKVLGLS KVARIVDMFA RRLQIQENLT 130 140 150 160 170 180 RQIAEAVRQV TSAAGVAVVI EAQHMCMMMR GVEKQNSQMF TSVMLGAFRD SNTTRQEFLQ LIGRSK

References

[1]

"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen." Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. , Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V. Nature 406:959-964(2000) [PubMed: 10984043] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004091 Genomic DNA. Translation: AAG06826.1.
PIR	D83217.
RefSeq	NP_252128.1.
3D structure databases
SMR	Q9HYG8. Positions 11-179.
ModBase	Search...
Genome annotation databases
GeneID	878765.
GenomeReviews	Gene locus PA3438 in contig AE004091_GR.
KEGG	pae:PA3438.
Organism-specific databases
PseudoCAP	PA3438.
CMR	Search...
Phylogenomic databases
HOGENOM	HBG370191.
OMA	AVFTESY.
Enzyme and pathway databases
BioCyc	PAER208964:PA3438-MONOMER.
BRENDA	3.5.4.16. 354.
Family and domain databases
HAMAP	MF_00223. FolE. [Tree]
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
TIGRFAMs	TIGR00063. folE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH11_PSEAE

Accession

Primary (citable) accession number: Q9HYG8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	March 1, 2001
Last modified:	February 9, 2010
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)