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Protein

Probable malate:quinone oxidoreductase 1

Gene

mqo1

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase 1 (mqo1), Probable malate:quinone oxidoreductase 2 (mqo2)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductase 1UniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQO 1UniRule annotation
Malate dehydrogenase [quinone] 1UniRule annotation
Gene namesi
Name:mqo1UniRule annotation
Synonyms:mqoA
Ordered Locus Names:PA3452
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA3452.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001287291 – 523Probable malate:quinone oxidoreductase 1Add BLAST523

Proteomic databases

PaxDbiQ9HYF4.
PRIDEiQ9HYF4.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA3452.

Structurei

3D structure databases

ProteinModelPortaliQ9HYF4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWT. Bacteria.
COG0579. LUCA.
HOGENOMiHOG000109379.
InParanoidiQ9HYF4.
KOiK00116.
OMAiEPIAATK.
PhylomeDBiQ9HYF4.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
HAMAPiMF_00212. MQO. 1 hit.
InterProiView protein in InterPro
IPR036188. FAD/NAD-bd_sf.
IPR006231. MQO.
PfamiView protein in Pfam
PF06039. Mqo. 1 hit.
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HYF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKILLMLLC VSVLGCSKNS VESEKPVDVL LIGGGIMSAT LGTYLNELEP
60 70 80 90 100
GWTIEMVERL DKVAEESSNG WNNAGTGHSA FCELNYTSEA ADGSMDISKA
110 120 130 140 150
VAINENFEIS KQFWAYQVDR KVLNDPKSFI NNVPHMSFVW GDDNVAFLKK
160 170 180 190 200
RHAALQHSSL FRGMEYSEDP EQIKQWVPLV MEGREPGQKI AATRMSIGTD
210 220 230 240 250
VNFGEITRQL VGSLSAKDTF KLRLQHEVRD LKRNDDNTWT VTMADLANGD
260 270 280 290 300
KETSVKARFV FIGAGGGALK LLQMSGIPEA EGYAGFPVGG SFLATTNPDV
310 320 330 340 350
VKRHLAKVYG KASVGSPPMS VPHLDTRMID GKPVLLFGPF ATFSTKFLKN
360 370 380 390 400
GSLWDLPGSV TSGNIGPMFN AGIDNFDLSQ YLIGQLMLSQ DDRMASLREY
410 420 430 440 450
FPEARDEDWK LVQAGQRVQI IKKDAEKGGV LQFGTEVVTA ADGSVAALLG
460 470 480 490 500
ASPGASTAAP IMLSVLEKAF KDKVATPEWQ ARLKEIVPSY GRKLNNDIEL
510 520
TNSTRAWSSE RLQLIHVPVQ PEA
Length:523
Mass (Da):57,210
Last modified:March 1, 2001 - v1
Checksum:i03E90117F88890B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG06840.1.
PIRiC83213.
RefSeqiNP_252142.1. NC_002516.2.
WP_003102300.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG06840; AAG06840; PA3452.
GeneIDi879029.
KEGGipae:PA3452.
PATRICifig|208964.12.peg.3614.

Similar proteinsi

Entry informationi

Entry nameiMQO1_PSEAE
AccessioniPrimary (citable) accession number: Q9HYF4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 1, 2001
Last modified: October 25, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families