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Q9HY84

- ASSY_PSEAE

UniProt

Q9HY84 - ASSY_PSEAE

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Protein

Argininosuccinate synthase

Gene
argG, PA3525
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei88 – 881Citrulline By similarity
Binding sitei93 – 931Citrulline By similarity
Binding sitei118 – 1181ATP; via amide nitrogen By similarity
Binding sitei120 – 1201Aspartate By similarity
Binding sitei124 – 1241Aspartate By similarity
Binding sitei124 – 1241Citrulline By similarity
Binding sitei125 – 1251Aspartate By similarity
Binding sitei128 – 1281Citrulline By similarity
Binding sitei179 – 1791Citrulline By similarity
Binding sitei188 – 1881Citrulline By similarity
Binding sitei264 – 2641Citrulline By similarity
Binding sitei276 – 2761Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:PA3525
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA3525.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Argininosuccinate synthaseUniRule annotationPRO_0000148626Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi208964.PA3525.

Structurei

3D structure databases

ProteinModelPortaliQ9HY84.
SMRiQ9HY84. Positions 3-402.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.
PhylomeDBiQ9HY84.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HY84-1 [UniParc]FASTAAdd to Basket

« Hide

MADVKKVVLA YSGGLDTSVI LKWLQDTYNC EVVTFTADLG QGEEVEPARA    50
KARAMGVKEI YIDDLREEFV RDFVYPMFRA NTVYEGEYLL GTSIARPLIA 100
KRLIEIANET GADAISHGAT GKGNDQVRFE LGAYALKPGV KVIAPWREWD 150
LLSREKLMDY AEKHGIPIER HGKKKSPYSM DANLLHISYE GGVLEDTWTE 200
HEEDMWKWTA SPENAPDTPT YIELTYRKGD IVAIDGKDMT PAEVLTELNR 250
VGGINGIGRL DIVENRYVGM KSRGCYETPG GTIMLKAHRA IESITLDREV 300
AHLKDELMPK YASLIYTGYW WSPERLMLQQ MIDASQVNVN GVVRLKLYKG 350
NVVVVGRKSD DSLFDANIAT FEEDGGAYNQ ADAAGFIKLN ALRMRIAANK 400
GRTLS 405
Length:405
Mass (Da):45,298
Last modified:March 1, 2001 - v1
Checksum:i1C3DB39EB18689E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG06913.1.
PIRiC83204.
RefSeqiNP_252215.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG06913; AAG06913; PA3525.
GeneIDi878872.
KEGGipae:PA3525.
PATRICi19841663. VBIPseAer58763_3689.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG06913.1 .
PIRi C83204.
RefSeqi NP_252215.1. NC_002516.2.

3D structure databases

ProteinModelPortali Q9HY84.
SMRi Q9HY84. Positions 3-402.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA3525.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG06913 ; AAG06913 ; PA3525 .
GeneIDi 878872.
KEGGi pae:PA3525.
PATRICi 19841663. VBIPseAer58763_3689.

Organism-specific databases

PseudoCAPi PA3525.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.
PhylomeDBi Q9HY84.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiASSY_PSEAE
AccessioniPrimary (citable) accession number: Q9HY84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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